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Information on EC 2.1.1.357 - [histone H3]-lysine36 N-dimethyltransferase and Organism(s) Mus musculus and UniProt Accession Q99MY8

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IUBMB Comments
This entry describes a group of metazoan enzymes that catalyse two successive methylations of lysine36 of histone H3 (H3K36), forming mono- and dimethylated forms. These modifications influence the binding of chromatin-associated proteins. Some enzymes can catalyse three methylations, forming a trimethylated form; these enzymes are classified under EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase.
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Mus musculus
UNIPROT: Q99MY8
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
mmset, whsc1, metnase, whsc1l1, h3k36 methyltransferase, histone h3 lysine 36 methyltransferase, h3k36-specific methyltransferase, nuclear receptor-binding set domain protein 2, kmt3b, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ash1L
gene name (absent, small, or homeotic discs 1-like)
KMT3B
-
-
-
-
KMT3C
-
-
-
-
SETMAR
-
-
-
-
Whsc1
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:[histone H3]-L-lysine36 N6-dimethyltransferase
This entry describes a group of metazoan enzymes that catalyse two successive methylations of lysine36 of histone H3 (H3K36), forming mono- and dimethylated forms. These modifications influence the binding of chromatin-associated proteins. Some enzymes can catalyse three methylations, forming a trimethylated form; these enzymes are classified under EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
show the reaction diagram
overall reaction
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
show the reaction diagram
-
-
-
?
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
show the reaction diagram
overall reaction
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
show the reaction diagram
-
-
-
?
additional information
?
-
the enzyme does not methylate free histone octamers or (H3-H4)2 tetramers bound to DNA
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
show the reaction diagram
overall reaction
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
show the reaction diagram
-
-
-
?
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
show the reaction diagram
overall reaction
-
-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
show the reaction diagram
-
-
-
?
additional information
?
-
the enzyme does not methylate free histone octamers or (H3-H4)2 tetramers bound to DNA
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
the enzyme methylates Lys36 of histone H3 to promote the establishment of Hox gene expression by counteracting polycomb silencing
malfunction
specific knockout of cardiac enzyme does not lead to ventricular remodelling
physiological function
the enzyme promotes ventricular remodelling mediated by the regulation of demethylation of [histone H3]-L-lysine36
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ASH1L_MOUSE
2958
0
331333
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhou, X.; Zhu, R.; Wu, X.; Xu, H.; Li, Y.; Xu, Q.; Liu, S.; Huang, H.; Xu, X.; Wan, L.; Wu, Q.; Liu, J.
NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2
J. Cell. Mol. Med.
23
568-575
2019
Mus musculus (Q8BVE8)
Manually annotated by BRENDA team
Miyazaki, H.; Higashimoto, K.; Yada, Y.; Endo, T.A.; Sharif, J.; Komori, T.; Matsuda, M.; Koseki, Y.; Nakayama, M.; Soejima, H.; Handa, H.; Koseki, H.; Hirose, S.; Nishioka, K.
Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract polycomb silencing
PLoS Genet.
9
e1003897
2013
Mus musculus (Q99MY8)
Manually annotated by BRENDA team