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Information on EC 2.1.1.356 - [histone H3]-lysine27 N-trimethyltransferase

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IUBMB Comments
This entry describes enzymes that successively methylate the L-lysine27 residue of histone H3 (H3K27), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. The methylation of lysine27 leads to transcriptional repression of the affected target genes. The enzyme associates with other proteins to form a complex that is essential for activity. The enzyme can also methylate some non-histone proteins.
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Word Map
  • 2.1.1.356
  • chromatin
  • trimethylation
  • zeste
  • noncoding
  • pluripotency
  • lncrnas
  • prc2-mediated
  • self-renewal
  • ectoderm
  • h3k4me3
  • jarid2
  • heterochromatin
  • epigenome
  • methyltransferases
  • nucleosome
  • bivalent
  • imprint
  • prc1
  • vernalization
  • demethylase
  • chip-seq
  • hotair
  • 3-deazaneplanocin
  • h3k27ac
  • trithorax
  • dznep
  • cdkn2a
  • ezh2-mediated
  • ctcf
  • homeotic
  • jumonji
  • chromatin-modifying
  • mpnsts
  • analysis
  • curly
  • polycomb-group
  • lysine-27
  • polycomb-mediated
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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3
+
a [histone H3]-L-lysine27
=
3
+
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
Synonyms
CLF, EZH1, EZH2, histone H3 lysine 27 methyltransferase, histone lysine methyltransferase, HMTase, interleukin-5 response element II binding protein, KMT6A, KMT6B, Polycomb repressive complex 2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
show the reaction diagram
overall reaction
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-
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S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
show the reaction diagram
(1a)
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-
-
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
show the reaction diagram
(1c)
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-
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S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27
show the reaction diagram
(1b)
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-
-
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