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Information on EC 2.1.1.354 - [histone H3]-lysine4 N-trimethyltransferase and Organism(s) Danio rerio and UniProt Accession Q6DHG0

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IUBMB Comments
This entry describes several enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In most cases the trimethylation of this position is associated with gene activation. EC 2.1.1.364, [histone H3]-lysine4 N-methyltransferase, describes enzymes that can catalyse only monomethylation of this substrate (the first sub-reaction of this entry); EC 2.1.1.370, [histone H3]-lysine4 N-dimethyltransferase, describes enzymes that catalyse only dimethylation of this substrate (the first two sub-reactions of this entry)
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This record set is specific for:
Danio rerio
UNIPROT: Q6DHG0
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Word Map
The taxonomic range for the selected organisms is: Danio rerio
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
compass, dot1l, smyd3, kmt2d, prdm9, kmt2a, smyd2, kmt2c, ash2l, setd1a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ash1L
-
-
-
-
KMT2A
-
-
-
-
KMT2B
-
-
-
-
KMT2C
-
-
-
-
KMT2D
-
-
-
-
KMT2E
-
-
-
-
KMT2F
-
-
-
-
KMT2G
-
-
-
-
KMT2H
-
-
-
-
KMT3C
-
-
-
-
KMT3E
-
-
-
-
MLL1
-
-
-
-
MLL2
-
-
-
-
MLL3
-
-
-
-
MLL4
-
-
-
-
MLL5
-
-
-
-
PRDM7
-
-
-
-
Prdm9
-
-
-
-
Setd1A
-
-
-
-
SMYD1
-
-
-
-
Smyd2
-
-
-
-
Smyd3
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-methyltransferase
This entry describes several enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In most cases the trimethylation of this position is associated with gene activation. EC 2.1.1.364, [histone H3]-lysine4 N-methyltransferase, describes enzymes that can catalyse only monomethylation of this substrate (the first sub-reaction of this entry); EC 2.1.1.370, [histone H3]-lysine4 N-dimethyltransferase, describes enzymes that catalyse only dimethylation of this substrate (the first two sub-reactions of this entry)
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
high expression within developing heart
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
knock-down of either histone H3 lysine methyltransferase Smyd3 or SetD7 genes leads to severe defects in cardiac morphogenesis without altering the expression pattern of heart markers, including cmlc2, vmhc, and amhc. Double knock-down of both Smyd3 and SetD7 causes synergistic defects in heart development. Overexpression of these genes also causes the heart morphogenesis defect in zebrafish
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SETD7_DANRE
373
0
41512
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, J.D.; Kim, E.; Koun, S.; Ham, H.J.; Rhee, M.; Kim, M.J.; Huh, T.L.
Proper activity of histone H3 lysine 4 (H3K4) methyltransferase is required for morphogenesis during zebrafish cardiogenesis
Mol. Cells
38
580-586
2015
Danio rerio (Q6DHG0), Danio rerio
Manually annotated by BRENDA team