Reference on EC 2.1.1.348 - mRNA m6A methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yue, Y.; Liu, J.; He, C.
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation
Genes Dev.
29
1343-1355
2015
Arabidopsis thaliana, Danio rerio, Saccharomyces cerevisiae, Drosophila melanogaster, Mus musculus
Bartosovic, M.; Molares, H.C.; Gregorova, P.; Hrossova, D.; Kudla, G.; Vanacova, S.
N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3-end processing
Nucleic Acids Res.
45
11356-11370
2017
Homo sapiens
Schwartz, S.; Mumbach, M.R.; Jovanovic, M.; Wang, T.; Maciag, K.; Bushkin, G.G.; Mertins, P.; Ter-Ovanesyan, D.; Habib, N.; Cacchiarelli, D.; Sanjana, N.E.; Freinkman, E.; Pacold, M.E.; Satija, R.; Mikkelsen, T.S.; Hacohen, N.; Zhang, F.; Carr, S.A.; Lander, E.S.; Regev, A.
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5 sites
Cell Rep.
8
284-296
2014
Homo sapiens (Q86U44 and Q9HCE5)
Ping, X.L.; Sun, B.F.; Wang, L.; Xiao, W.; Yang, X.; Wang, W.J.; Adhikari, S.; Shi, Y.; Lv, Y.; Chen, Y.S.; Zhao, X.; Li, A.; Yang, Y.; Dahal, U.; Lou, X.M.; Liu, X.; Huang, J.; Yuan, W.P.; Zhu, X.F.; Cheng, T.; Zhao, Y.L.; Wang, X.; Rendtlew Danielsen, J.M.; Liu, F.; Yang, Y.G.
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
Cell Res.
24
177-189
2014
Danio rerio (F1R777), Danio rerio, Homo sapiens (Q86U44 and Q9HCE5), Homo sapiens
Li, F.; Kennedy, S.; Hajian, T.; Gibson, E.; Seitova, A.; Xu, C.; Arrowsmith, C.H.; Vedadi, M.
A radioactivity-based assay for screening human m6A-RNA methyltransferase, METTL3-METTL14 complex, and demethylase ALKBH5
J. Biomol. Screen.
21
290-297
2016
Homo sapiens (Q86U44 and Q9HCE5), Homo sapiens
Li, Q.; Li, X.; Tang, H.; Jiang, B.; Dou, Y.; Gorospe, M.; Wang, W.
NSUN2-mediated m5C methylation and METTL3/METTL14-mediated m6A methylation cooperatively enhance p21 translation
J. Cell. Biochem.
118
2587-2598
2017
Homo sapiens (Q86U44 and Q9HCE5)
Feng, Z.; Li, Q.; Meng, R.; Yi, B.; Xu, Q.
METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells
J. Cell. Mol. Med.
22
2558-2568
2018
Homo sapiens (Q86U44 and Q9HCE5), Homo sapiens
Lin, S.; Choe, J.; Du, P.; Triboulet, R.; Gregory, R.I.
The m(6)A methyltransferase METTL3 promotes translation in human cancer cells
Mol. Cell
62
335-345
2016
Homo sapiens (Q86U44), Homo sapiens
Wang, P.; Doxtader, K.A.; Nam, Y.
Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases
Mol. Cell
63
306-317
2016
Homo sapiens (Q86U44 and Q9HCE5)
Liu, J.; Yue, Y.; Han, D.; Wang, X.; Fu, Y.; Zhang, L.; Jia, G.; Yu, M.; Lu, Z.; Deng, X.; Dai, Q.; Chen, W.; He, C.
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Nat. Chem. Biol.
10
93-95
2014
Homo sapiens (Q86U44 and Q9HCE5), Homo sapiens
Wang, X.; Feng, J.; Xue, Y.; Guan, Z.; Zhang, D.; Liu, Z.; Gong, Z.; Wang, Q.; Huang, J.; Tang, C.; Zou, T.; Yin, P.
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
Nature
534
575-578
2016
Homo sapiens (Q86U44 and Q9HCE5)
Patil, D.P.; Chen, C.K.; Pickering, B.F.; Chow, A.; Jackson, C.; Guttman, M.; Jaffrey, S.R.
m(6)A RNA methylation promotes XIST-mediated transcriptional repression
Nature
537
369-373
2016
Homo sapiens (Q86U44), Homo sapiens
Du, Y.; Hou, G.; Zhang, H.; Dou, J.; He, J.; Guo, Y.; Li, L.; Chen, R.; Wang, Y.; Deng, R.; Huang, J.; Jiang, B.; Xu, M.; Cheng, J.; Chen, G.Q.; Zhao, X.; Yu, J.
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function
Nucleic Acids Res.
46
5195-5208
2018
Homo sapiens (Q86U44 and Q9HCE5), Homo sapiens
Huang, J.; Dong, X.; Gong, Z.; Qin, L.; Yang, S.; Zhu, Y.; Wang, X.; Zhang, D.; Zou, T.; Yin, P.; Tang, C.
Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase
Protein Cell
10
272-284
2018
Homo sapiens (Q86U44 and Q9HCE5)
Geula, S.; Moshitch-Moshkovitz, S.; Dominissini, D.; Mansour, A.; Kol, N.; Salmon-Divon, M.; Hershkovitz, V.; Peer, E.; Mor, N.; Manor, Y.; Ben-Haim, M.; Eyal, E.; Yunger, S.; Pinto, Y.; Jaitin, D.; Viukov, S.; Rais, Y.; Krupalnik, V.; Chomsky, E.; Zerbib, M.; Maza, I.; Rechavi, Y.; Massarwa, R.; Hanna, S.; Amit, I.; Levanon, E.Y.; Amariglio, N.; Stern-Ginossar, N.; Novershtern, N.; Rechavi, G.; Hanna, J.H.
m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation
Science
347
1002-1006
2015
Mus musculus (Q8C3P7), Mus musculus
Miao, W.; Chen, J.; Jia, L.; Ma, J.; Song, D.
The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1
Biochem. Biophys. Res. Commun.
516
719-725
2019
Homo sapiens (Q86U44), Homo sapiens
Xie, W.; Ma, L.; Xu, Y.; Wang, B.; Li, S.
METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism
Biochem. Biophys. Res. Commun.
518
120-126
2019
Mus musculus (Q8C3P7), Mus musculus
Wanna-Udom, S.; Terashima, M.; Lyu, H.; Ishimura, A.; Takino, T.; Sakari, M.; Tsukahara, T.; Suzuki, T.
The m6A methyltransferase METTL3 contributes to transforming growth factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB
Biochem. Biophys. Res. Commun.
524
150-155
2020
Homo sapiens (Q86U44)
Nakano, M.; Ondo, K.; Takemoto, S.; Fukami, T.; Nakajima, M.
Methylation of adenosine at the N6 position post-transcriptionally regulates hepatic P450s expression
Biochem. Pharmacol.
171
113697
2020
Homo sapiens (Q86U44 and Q9HCE5), Homo sapiens
Cai, X.; Wang, X.; Cao, C.; Gao, Y.; Zhang, S.; Yang, Z.; Liu, Y.; Zhang, X.; Zhang, W.; Ye, L.
HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor et-7g
Cancer Lett.
415
11-19
2018
Homo sapiens (Q86U44)
Woodcock, C.; Yu, D.; Hajian, T.; Li, J.; Huang, Y.; Dai, N.; Correa, I.J.; Wu, T.; Vedadi, M.; Zhang, X.; Cheng, X.
Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro
Cell Discov.
5
63
2019
Homo sapiens (Q86U44 and Q9HCE5)
Selberg, S.; Blokhina, D.; Aatonen, M.; Koivisto, P.; Siltanen, A.; Mervaala, E.; Kankuri, E.; Karelson, M.
Discovery of small molecules that activate RNA methylation through cooperative binding to the METTL3-14-WTAP complex active site
Cell Rep.
26
3762-3771
2019
Homo sapiens (Q86U44)
Zhang, Z.; Wang, M.; Xie, D.; Huang, Z.; Zhang, L.; Yang, Y.; Ma, D.; Li, W.; Zhou, Q.; Yang, Y.G.; Wang, X.J.
METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation
Cell Res.
28
1050-1061
2018
Mus musculus (Q8C3P7), Mus musculus
Yao, Q.; Sang, L.; Lin, M.; Yin, X.; Dong, W.; Gong, Y.; Zhou, B.
Mettl3-Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells
Cell Res.
28
952-954
2018
Mus musculus (Q8C3P7 and Q3UIK4)
Dorn, L.E.; Lasman, L.; Chen, J.; Xu, X.; Hund, T.J.; Medvedovic, M.; Hanna, J.H.; van Berlo, J.H.; Accornero, F.
The N6-methyladenosine mRNA methylase METTL3 controls cardiac homeostasis and hypertrophy
Circulation
139
533-545
2019
Mus musculus (Q8C3P7), Mus musculus
Chen, M.; Wie, L.; Law, C.T.; Tsang, F.H.; Shen, J.; Cheng, C.L.; Tsang, L.H.; Ho, D.W.; Chiu, D.K.; Lee, J.M.; Wong, C.C.; Ng, I.O.; Wong, C.M.
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
Hepatology
67
2254-2270
2018
Homo sapiens
Liu, J.; Yue, Y.; He, C.
Preparation of human nuclear RNA m6A methyltransferases and demethylases and biochemical characterization of their catalytic activity
Methods Enzymol.
560
117-130
2015
Homo sapiens (Q86U44), Homo sapiens (Q9HCE5)
Yu, J.; Shen, L.; Liu, Y.; Ming, H.; Zhu, X.; Chu, M.; Lin, J.
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-kappaB signaling
Mol. Cell. Biochem.
463
203-210
2020
Homo sapiens (Q86U44)
Kobayashi, M.; Ohsugi, M.; Sasako, T.; Awazawa, M.; Umehara, T.; Iwane, A.; Kobayashi, N.; Okazaki, Y.; Kubota, N.; Suzuki, R.; Waki, H.; Horiuchi, K.; Hamakubo, T.; Kodama, T.; Aoe, S.; Tobe, K.; Kadowaki, T.; Ueki, K.
The RNA methyltransferase complex of WTAP, METTL3, and METTL14 regulates mitotic clonal expansion in adipogenesis
Mol. Cell. Biol.
38
e00116-18
2018
Mus musculus (Q8C3P7 and Q3UIK4)
Lee, H.; Bao, S.; Qian, Y.; Geula, S.; Leslie, J.; Zhang, C.; Hanna, J.H.; Ding, L.
Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation
Nat. Cell Biol.
21
700-709
2019
Mus musculus (Q8C3P7)
Wang, H.; Hu, X.; Huang, M.; Liu, J.; Gu, Y.; Ma, L.; Zhou, Q.; Cao, X.
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
Nat. Commun.
10
1898
2019
Mus musculus (Q8C3P7)
Wu, Y.; Xie, L.; Wang, M.; Xiong, Q.; Guo, Y.; Liang, Y.; Li, J.; Sheng, R.; Deng, P.; Wang, Y.; Zheng, R.; Jiang, Y.; Ye, L.; Chen, Q.; Zhou, X.; Lin, S.; Yuan, Q.
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
Nat. Commun.
9
4772
2018
Mus musculus (Q8C3P7)
Alarcon, C.R.; Lee, H.; Goodarzi, H.; Halberg, N.; Tavazoie, S.F.
N6-methyladenosine marks primary microRNAs for processing.
Nature
519
482-485
2015
Homo sapiens (Q86U44)
Wang, X.; Feng, J.; Xue, Y.; Guan, Z.; Zhang, D.; Liu, Z.; Gong, Z.; Wang, Q.; Huang, J.; Tang, C.; Zou, T.; Yin, P.
Corrigendum Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature
542
260
2017
Homo sapiens
Hao, H.; Hao, S.; Chen, H.; Chen, Z.; Zhang, Y.; Wang, J.; Wang, H.; Zhang, B.; Qiu, J.; Deng, F.; Guan, W.
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication
Nucleic Acids Res.
47
362-374
2019
Chlorocebus aethiops, Chlorocebus sabaeus
Xia, T.; Wu, X.; Cao, M.; Zhang, P.; Shi, G.; Zhang, J.; Lu, Z.; Wu, P.; Cai, B.; Miao, Y.; Jiang, K.
The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion
Pathol. Res. Pract.
215
152666
2019
Homo sapiens (Q86U44), Homo sapiens
Zhang, F.; Zhang, Y.C.; Liao, J.Y.; Yu, Y.; Zhou, Y.F.; Feng, Y.Z.; Yang, Y.W.; Lei, M.Q.; Bai, M.; Wu, H.; Chen, Y.Q.
The subunit of RNA N6-methyladenosine methyltransferase OsFIP regulates early degeneration of microspores in rice.
PLoS Genet.
15
e1008120
2019
Oryza sativa
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