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Information on EC 2.1.1.346 - U6 snRNA m6A methyltransferase and Organism(s) Mus musculus and UniProt Accession Q9CQG2

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.346 U6 snRNA m6A methyltransferase
IUBMB Comments
This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA. The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, methionine adenosyltransferase, that produces S-adenosyl-L-methionine [1,2]. The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions .
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This record set is specific for:
Mus musculus
UNIPROT: Q9CQG2
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
mettl16, n6-methyladenosine (m6a) methyltransferase, m6a rna methyltransferase, rna m6a methyltransferase, methyltransferase-like protein 16, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
m6A methyltransferase
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METTL16
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:adenine in U6 snRNA methyltransferase
This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA. The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, methionine adenosyltransferase, that produces S-adenosyl-L-methionine [1,2]. The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions [2].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + adenine in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + adenine in U6 snRNA
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
show the reaction diagram
regulation of Mat2a mRNA by Mettl16 is essential for mouse embryonic development
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-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
mouse 16-cell embryos lacking Mettl16 display reduced mRNA levels of its methylation target, the S-adenosyl-L-methionine synthetase Mat2a
physiological function
regulation of Mat2a mRNA by Mettl16 is essential for mouse embryonic development
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MET16_MOUSE
553
0
62341
Swiss-Prot
other Location (Reliability: 4)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mendel, M.; Chen, K.M.; Homolka, D.; Gos, P.; Pandey, R.R.; McCarthy, A.A.; Pillai, R.S.
Methylation of structured RNA by the m6A writer METTL16 is essential for mouse embryonic development
Mol. Cell
71
986-1000
2018
Homo sapiens (Q86W50), Homo sapiens, Mus musculus (Q9CQG2), Mus musculus
Manually annotated by BRENDA team