Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.1.1.34 - tRNA (guanosine18-2'-O)-methyltransferase and Organism(s) Homo sapiens and UniProt Accession Q13395

for references in articles please use BRENDA:EC2.1.1.34
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.34 tRNA (guanosine18-2'-O)-methyltransferase
IUBMB Comments
The enzyme catalyses the methylation of guanosine18 in tRNA.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: Q13395
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
tarbp1, trna (gm18) methyltransferase, transfer rna (gm18) methyltransferase, trna (gm18) 2'-o-methyltransferase, trna gm18 methyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyltransferase, transfer ribonucleate guanosine 2'-
-
-
-
-
S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase
-
-
-
-
transfer ribonucleate guanosine 2'-methyltransferase
-
-
-
-
tRNA (guanosine-2'-O-)-methyltransferase
-
-
-
-
tRNA guanosine 2'-methyltransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:tRNA (guanosine18-2'-O)-methyltransferase
The enzyme catalyses the methylation of guanosine18 in tRNA.
CAS REGISTRY NUMBER
COMMENTARY hide
37257-01-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
mutation of TARBP1 results in loss of Gm18 within tRNA. Lack of Gm18 across results in increased immunostimulation of peripheral blood mononuclear cells when activated by tRNA preparations.Lack of Gm18 in yeasts and human cells does not affect immunostimulation by whole RNA preparations
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
TARB1_HUMAN
1621
0
181675
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Freund, I.; Buhl, D.K.; Boutin, S.; Kotter, A.; Pichot, F.; Marchand, V.; Vierbuchen, T.; Heine, H.; Motorin, Y.; Helm, M.; Dalpke, A.H.; Eigenbrod, T.
2-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms
RNA
25
869-880
2019
Escherichia coli, Escherichia coli BW25113, Homo sapiens (Q13395), Homo sapiens, Saccharomyces cerevisiae
Manually annotated by BRENDA team