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IUBMB CommentsFound in hops (Humulus lupulus). The enzyme can also methylate xanthogalenol.
The expected taxonomic range for this enzyme is: Humulus lupulus
Synonyms
s-adenosyl-l-methionine-dependent o-methyltransferase, more
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S-adenosyl-L-methionine-dependent O-methyltransferase
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S-adenosyl-L-methionine + desmethylxanthohumol = S-adenosyl-L-homocysteine + xanthohumol
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MetaCyc
xanthohumol biosynthesis
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S-adenosyl-L-methionine:desmethylxanthohumol 6'-O-methyltransferase
Found in hops (Humulus lupulus). The enzyme can also methylate xanthogalenol.
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S-adenosyl-L-methionine + caffeic acid
S-adenosyl-L-homocysteine + ?
Substrates: -
Products: 7% of the activity with desmethylxanthohumol
?
S-adenosyl-L-methionine + desmethylxanthohumol
S-adenosyl-L-homocysteine + xanthohumol
Substrates: -
Products: -
?
S-adenosyl-L-methionine + xanthogalenol
S-adenosyl-L-homocysteine + ?
Substrates: 445% of the activity with desmethylxanthohumol
Products: -
?
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additional information
bivalent cations (Mg2+, Fe2+, Zn2+, Cu2+, Ca2+, and Co2+) are not required for activity
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desmethylxanthohumol
competitive with respect to xanthohumol
S-adenosyl-L-homocysteine
-
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0.018
desmethylxanthohumol
pH 7.5, 30°C
0.286
S-adenosyl-L-methionine
pH 7.5, 30°C
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0.002
desmethylxanthohumol
pH 7.5, 30°C
0.098
S-adenosyl-L-homocysteine
pH 7.5, 30°C
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UniProt
brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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physiological function
OMT1 performs the final reaction in xanthohumol biosynthesis by methylating desmethylxanthohumol to form xanthohumol
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OMT1_HUMLU
352
0
39266
Swiss-Prot
-
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dimer
2 * 39265, calculated
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Nagel, J.; Culley, L.; Lu, Y.; Liu, E.; Matthews, P.; Stevens, J.; Page, J.
EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol
Plant Cell
20
186-200
2008
Humulus lupulus (B0ZB55)
brenda
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