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Information on EC 2.1.1.329 - demethylphylloquinol methyltransferase and Organism(s) Arabidopsis thaliana and UniProt Accession Q3ED65

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.329 demethylphylloquinol methyltransferase
IUBMB Comments
The enzyme, found in plants and cyanobacteria, catalyses the final step in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is specific for the quinol form of the substrate, and does not act on the quinone form .
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q3ED65
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
demethylnaphthoquinone methyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
demethylnaphthoquinone methyltransferase
-
PNQ methyltransferase
-
2-phytyl-1,4-naphthoquinol methyltransferase
-
-
-
-
menG
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinol C-methyltransferase
The enzyme, found in plants and cyanobacteria, catalyses the final step in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is specific for the quinol form of the substrate, and does not act on the quinone form [3].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + demethylphylloquinol
S-adenosyl-L-homocysteine + phylloquinol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + demethylphylloquinone
S-adenosyl-L-homocysteine + phylloquinone
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + menadione
?
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + demethylphylloquinol
S-adenosyl-L-homocysteine + phylloquinol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + demethylphylloquinone
S-adenosyl-L-homocysteine + phylloquinone
show the reaction diagram
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.02
menadione
at pH 7.5 and 30°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.44
menadione
at pH 7.5 and 30°C
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
22
menadione
at pH 7.5 and 30°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, Photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MENG_ARATH
261
0
29051
Swiss-Prot
Chloroplast (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in a Synechocystis sp. PCC6803 menG knockout mutant
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fatihi, A.; Latimer, S.; Schmollinger, S.; Block, A.; Dussault, P.H.; Vermaas, W.F.; Merchant, S.S.; Basset, G.J.
A dedicated type II NADPH dehydrogenase performs the penultimate step in the biosynthesis of vitamin K1 in Synechocystis and Arabidopsis
Plant Cell
27
1730-1741
2015
Arabidopsis thaliana (Q3ED65), Arabidopsis thaliana
Manually annotated by BRENDA team
Lohmann, A.; Schoettler, M.A.; Brehelin, C.; Kessler, F.; Bock, R.; Cahoon, E.B.; Doermann, P.
Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant
J. Biol. Chem.
281
40461-40472
2006
Arabidopsis thaliana (Q3ED65)
Manually annotated by BRENDA team