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BRENDA support

Information on EC 2.1.1.324 - dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase

for references in articles please use BRENDA:EC2.1.1.324

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IUBMB Comments

The enzyme was isolated from the bacterium Saccharopolyspora spinosa, where it is involved in the biosynthesis of spinosyn A, an active ingredient of several commercial insecticides.

The expected taxonomic range for this enzyme is: Saccharopolyspora spinosa

Synonyms
SpnS, TDP-4-amino-2,3,6-trideoxy-D-glucose N,N-dimethyltransferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = 2 S-adenosyl-L-homocysteine + dTDP-alpha-D-forosamine
show the reaction diagram
overall reaction
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S-adenosyl-L-methionine + dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = S-adenosyl-L-homocysteine + dTDP-alpha-D-forosamine
show the reaction diagram
(1b)
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S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = S-adenosyl-L-homocysteine + dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose
show the reaction diagram
(1a)
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