Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.1.1.311 - 25S rRNA (cytosine2278-C5)-methyltransferase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P53972

for references in articles please use BRENDA:EC2.1.1.311
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme, found in eukaryotes, is specific for 25S cytosine2278. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae .
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Saccharomyces cerevisiae
UNIPROT: P53972
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
RCM1, ribosomal RNA cytosine methyltransferase 1, YNL022C, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ribosomal RNA cytosine methyltransferase 1
-
RCM1
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:25S rRNA (cytosine2278-C5)-methyltransferase
The enzyme, found in eukaryotes, is specific for 25S cytosine2278. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae [1].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cytosine2278 in 25S rRNA
S-adenosyl-L-homocysteine + 5-methylcytosine2278 in 25S rRNA
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
downregulated in chronologically aged yeast cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schosserer, M.; Minois, N.; Angerer, T.B.; Amring, M.; Dellago, H.; Harreither, E.; Calle-Perez, A.; Pircher, A.; Gerstl, M.P.; Pfeifenberger, S.; Brandl, C.; Sonntagbauer, M.; Kriegner, A.; Linder, A.; Weinhaeusel, A.; Mohr, T.; Steiger, M.; Mattanovich, D.; Rinnerthaler, M.; Karl, T.; Sharma, S.
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan
Nat. Commun.
6
6158
2015
Saccharomyces cerevisiae (P53972), Saccharomyces cerevisiae ATCC 204508 (P53972)
Manually annotated by BRENDA team
Sharma, S.; Yang, J.; Watzinger, P.; Koetter, P.; Entian, K.D.
Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively
Nucleic Acids Res.
41
9062-9076
2013
Saccharomyces cerevisiae (P53972), Saccharomyces cerevisiae ATCC 204508 (P53972)
Manually annotated by BRENDA team
Gigova, A.; Duggimpudi, S.; Pollex, T.; Schaefer, M.; Kos, M.
A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability
RNA
20
1632-1644
2014
Saccharomyces cerevisiae (P53972), Saccharomyces cerevisiae ATCC 204508 (P53972)
Manually annotated by BRENDA team