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Information on EC 2.1.1.296 - methyltransferase cap2

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.296 methyltransferase cap2
IUBMB Comments
The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the ribonucleotide at the second transcribed position of mRNAs and snRNAs. This methylation event is known as cap2. The human enzyme can also methylate mRNA molecules where the upstream ribonucleotide is not methylated (see EC 2.1.1.57, methyltransferase cap1), but with lower efficiency .
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This record set is specific for:
UNIPROT: Q9CYT6
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Word Map
  • 2.1.1.296
  • c-mannosylation
  • mannose
  • neuroblast
  • thrombospondin
  • 2'-o-ribose
  • r-spondin1
  • methyltransferases
  • netrin
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-(ribonucleotide)-[mRNA]
=
+
a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA]
Synonyms
hmtr2, cmtr2, ftsjd1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CMTr2
-
-
-
-
MTR2
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-ribonucleotide-[mRNA] 2'-O-methyltransferase
The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the ribonucleotide at the second transcribed position of mRNAs and snRNAs. This methylation event is known as cap2. The human enzyme can also methylate mRNA molecules where the upstream ribonucleotide is not methylated (see EC 2.1.1.57, methyltransferase cap1), but with lower efficiency [2].
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
cultured lens cell
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
enzyme Cap2 expression is regulated by Pax6, a key regulator of the entire cascade of ocular lens formation through specific binding to promoters and enhancers of batteries of target genes
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CAP2_MOUSE
476
0
52862
Swiss-Prot
Secretory Pathway (Reliability: 4)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene cap2, quantitative RT-PCR expression analysis
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the shRNA-mediated knockdown of transcription factor Pax6 reveals downregulation of a set of direct target genes, including Cap2, Farp1, Pax6, Plekha1, Prox1, Tshz2, and Zfp536
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sun, J.; Zhao, Y.; McGreal, R.; Cohen-Tayar, Y.; Rockowitz, S.; Wilczek, C.; Ashery-Padan, R.; Shechter, D.; Zheng, D.; Cvekl, A.
Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers
Epigenetics Chromatin
9
37
2016
Mus musculus (Q9CYT6)
Manually annotated by BRENDA team