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Information on EC 2.1.1.288 - aklanonic acid methyltransferase and Organism(s) Streptomyces sp. and UniProt Accession Q55214

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.288 aklanonic acid methyltransferase
IUBMB Comments
The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin.
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Streptomyces sp.
UNIPROT: Q55214
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The taxonomic range for the selected organisms is: Streptomyces sp.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
aklanonic acid methyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aklanonate methyltransferase
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:aklanonate O-methyltransferase
The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + aklanonate
S-adenosyl-L-homocysteine + methyl aklanonate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + aklanonate
S-adenosyl-L-homocysteine + methyl aklanonate
show the reaction diagram
the enzyme is involved in daunomycin biosynthesis
-
-
?
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is involved in the biosynthesis of the anthracycline daunorubicin
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
24000
2 * 24000, SDS-PAGE
24319
2 * 24319, SDS-PAGE
48000
gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
the dauC gene, encoding aklanonic acid methyltransferase, complements dauC-blocked mutants of Streptomyces sp. strain C5, restores in vitro aklanonic acid methyltransferase activities to the mutant strains, and confers in vitro aklanonic acid methyltransferase activity on Streptomyces lividans
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dickens, M.L.; Ye, J.; Strohl, W.R.
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5
J. Bacteriol.
177
536-543
1995
Streptomyces sp. (Q55214)
Manually annotated by BRENDA team