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Information on EC 2.1.1.255 - geranyl diphosphate 2-C-methyltransferase and Organism(s) Streptomyces ambofaciens and UniProt Accession A3KI18

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.255 geranyl diphosphate 2-C-methyltransferase
IUBMB Comments
This enzyme, along with EC 4.2.3.118, 2-methylisoborneol synthase, produces 2-methylisoborneol, an odiferous compound produced by soil microorganisms with a strong earthy/musty odour.
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This record set is specific for:
Streptomyces ambofaciens
UNIPROT: A3KI18
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Word Map
The taxonomic range for the selected organisms is: Streptomyces ambofaciens
The enzyme appears in selected viruses and cellular organisms
Synonyms
gppmt, c-methyl transferase, sco7701, gpp methyltransferase, geranyl diphosphate 2-methyltransferase, sco7701 protein, geranyl pyrophosphate methyltransferase, geranyl diphosphate c-methyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
GPP methyltransferase
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2-methyl-GPP synthase
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geranyl pyrophosphate methyltransferase
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GPP methyltransferase
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GPPMT
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MGPPS
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SCO7701
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + geranyl diphosphate = S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
show the reaction diagram
biosynthetic mechanism, overview
PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:geranyl-diphosphate 2-C-methyltransferase
This enzyme, along with EC 4.2.3.118, 2-methylisoborneol synthase, produces 2-methylisoborneol, an odiferous compound produced by soil microorganisms with a strong earthy/musty odour.
CAS REGISTRY NUMBER
COMMENTARY hide
57219-74-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + geranyl diphosphate
S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + geranyl diphosphate
S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
S-adenosyl-L-methionine
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
the enzyme is important in the biosynthesis of 2-methylisoborneol, which involves the methylation of geranyl diphosphate by GPP methyltransferase and its subsequent cyclization by monoterpene cyclase to 2-methylisoborneol
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, genetic organization, phylogenetic analysis and tree, expression in Escherichia coli
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Komatsu, M.; Tsuda, M.; Omura, S.; Oikawa. H.; Ikeda, H.
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol
Proc. Natl. Acad. Sci. USA
105
7422-7427
2008
Micromonospora olivasterospora (F5HSX5), Micromonospora olivasterospora, Micromonospora olivasterospora KY11048 (F5HSX5), Micromonospora olivasterospora KY11048, Saccharopolyspora erythraea (A4FG18), Saccharopolyspora erythraea, Saccharopolyspora erythraea NRRL 2338 (A4FG18), Saccharopolyspora erythraea NRRL 2338, Streptomyces ambofaciens (A3KI18), Streptomyces ambofaciens ISP5053 (A3KI18), Streptomyces lasalocidi (D3KYU3), Streptomyces lasalocidi, Streptomyces lasalocidi NRRL2382R (D3KYU3)
Manually annotated by BRENDA team