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Information on EC 2.1.1.228 - tRNA (guanine37-N1)-methyltransferase

for references in articles please use BRENDA:EC2.1.1.228

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IUBMB Comments

This enzyme is important for the maintenance of the correct reading frame during translation. Unlike TrmD from Escherichia coli, which recognizes the G36pG37 motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37 .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes

Synonyms
trna methyltransferase, trna(m1g37)methyltransferase, patrmd, trna(m(1)g37)methyltransferase, trm5p, patrm5a, trna (m1g37) methyltransferase, trmt5, attrm5a, patrm5b, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + guanine37 in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
7-(3-amino-3-carboxypropyl)-wyosine biosynthesis, methylwyosine biosynthesis, tRNA methylation (yeast)