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Information on EC 2.1.1.205 - tRNA (cytidine32/guanosine34-2'-O)-methyltransferase for references in articles please use BRENDA:EC2.1.1.205
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EC Tree
IUBMB Comments The enzyme from Saccharomyces cerevisiae catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe, tRNATrp and, possibly, tRNALeu.
The expected taxonomic range for this enzyme is: Saccharomyces cerevisiae
Reaction Schemes
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cytidine32/guanosine34 in tRNA
=
+
2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA
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S-adenosyl-L-methionine + cytidine32/guanosine34 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA
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S-adenosyl-L-methionine:tRNA (cytidine32/guanosine34-2'-O)-methyltransferase
The enzyme from Saccharomyces cerevisiae catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe, tRNATrp and, possibly, tRNALeu.
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S-adenosyl-L-methionine + cytidine32/guanosine34 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA
S-adenosyl-L-methionine + cytidine32/guanosine34 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA
the enzyme catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe, tRNATrp and, possibly, tRNALeu
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S-adenosyl-L-methionine + cytidine32/guanosine34 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA
Trm7p methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop, both in vivo and in vitro
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S-adenosyl-L-methionine + cytidine32/guanosine34 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA
P38238
the enzyme catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe, tRNATrp and, possibly, tRNALeu
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SwissProt
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malfunction
a trm7DELTA strain, which is viable but grows slowly, translation is impaired. Protein synthesis is reduced to 30% in the deleted strain, compared with an isogenic wild-type strain. The formation of 2'-O-methylcytidine32 and guanosine34 is abolished in the trm7DELTA strain
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Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
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D49A
abolishes almost completely the formation of 2'-O-methylcytidine32, no activity is detected for guanine34
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wild-type and mutant strain D49A
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Pintard, L.; Lecointe, F.; Bujnicki, J.M.; Bonnerot, C.; Grosjean, H.; Lapeyre, B.
Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop
EMBO J.
21
1811-1820
2002
Saccharomyces cerevisiae (P38238), Saccharomyces cerevisiae
brenda
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2.1.1.205 tRNA (cytidine32/guanosine34-2'-O)-methyltransferase
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