Reference on EC 2.1.1.202 - multisite-specific tRNA:(cytosine-C5)-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Motorin, Y.; Grosjean, H.
Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme
RNA
5
1105-1118
1999
Saccharomyces cerevisiae (P38205), Saccharomyces cerevisiae
King, M.Y.; Redman, K.L.
RNA methyltransferases utilize two cysteine residues in the formation of 5-methylcytosine
Biochemistry
41
11218-11225
2002
Saccharomyces cerevisiae
Redman, K.L.
Assembly of protein-RNA complexes using natural RNA and mutant forms of an RNA cytosine methyltransferase
Biomacromolecules
7
3321-3326
2006
Saccharomyces cerevisiae
Strobel, M.C.; Abelson, J.
Effect of intron mutations on processing and function of Saccharomyces cerevisiae SUP53 tRNA in vitro and in vivo
Mol. Cell. Biol.
6
2663-2673
1986
Saccharomyces cerevisiae
Jiang, H.Q.; Motorin, Y.; Jin, Y.X.; Grosjean, H.
Pleiotropic effects of intron removal on base modification pattern of yeast tRNAPhe: an in vitro study
Nucleic Acids Res.
25
2694-2701
1997
Saccharomyces cerevisiae, Saccharomyces cerevisiae Pp1001
Brzezicha, B.; Schmidt, M.; Makalowska, I.; Jarmolowski, A.; Pienkowska, J.; Szweykowska-Kulinska, Z.
Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu(CAA)
Nucleic Acids Res.
34
6034-6043
2006
Saccharomyces cerevisiae (P38205), Saccharomyces cerevisiae
Walbott, H.; Husson, C.; Auxilien, S.; Golinelli-Pimpaneau, B.
Cysteine of sequence motif VI is essential for nucleophilic catalysis by yeast tRNA m5C methyltransferase
RNA
13
967-973
2007
Saccharomyces cerevisiae
Awai, T.; Ochi, A.; Ihsanawati, A.; Sengoku, T.; Hirata, A.; Bessho, Y.; Yokoyama, S.; Hori, H.
Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure
J. Biol. Chem.
286
35236-35246
2011
Methanocaldococcus jannaschii
Moon, H.J.; Redman, K.L.
Trm4 and Nsun2 RNA:m5C methyltransferases form metabolite-dependent, covalent adducts with previously methylated RNA
Biochemistry
53
7132-7144
2014
Saccharomyces cerevisiae
Burgess, A.; David, R.; Searle, I.
Conservation of tRNA and rRNA 5-methylcytosine in the kingdom Plantae
BMC Plant Biol.
15
199
2015
Arabidopsis thaliana, Brassica rapa, Ginkgo biloba, Triticum turgidum subsp. durum, Nannochloropsis oculata, Caulerpa taxifolia
Hussain, S.; Sajini, A.A.; Blanco, S.; Dietmann, S.; Lombard, P.; Sugimoto, Y.; Paramor, M.; Gleeson, J.G.; Odom, D.T.; Ule, J.; Frye, M.
NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs
Cell Rep.
4
255-261
2013
Homo sapiens
Khoddami, V.; Cairns, B.R.
Identification of direct targets and modified bases of RNA cytosine methyltransferases
Nat. Biotechnol.
31
458-464
2013
Homo sapiens
Preston, M.; DSilva, S.; Kon, Y.; Phizicky, E.
TRNAHis 5-methylcytidine levels increase in response to several growth arrest conditions in Saccharomyces cerevisiae
RNA
19
243-256
2013
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Bohnsack, K.; Hoebartner, C.; Bohnsack, M.
Eukaryotic 5-methylcytosine (M5C) RNA methyltransferases mechanisms, cellular functions, and links to disease
Genes (Basel)
10
102
2019
Pyrococcus horikoshii (O57712), Homo sapiens (Q08J23), Homo sapiens (Q8TEA1), Pyrococcus horikoshii DSM 12428 (O57712), Pyrococcus horikoshii NBRC 100139 (O57712), Pyrococcus horikoshii JCM 9974 (O57712), Pyrococcus horikoshii ATCC 700860 (O57712), Pyrococcus horikoshii OT-3 (O57712)
Cui, X.; Liang, Z.; Shen, L.; Zhang, Q.; Bao, S.; Geng, Y.; Zhang, B.; Leo, V.; Vardy, L.A.; Lu, T.; Gu, X.; Yu, H.
5-Methylcytosine RNA methylation in Arabidopsis thaliana
Mol. Plant
10
1387-1399
2017
Arabidopsis thaliana
Liu, R.; Long, T.; Li, J.; Li, H.; Wang, E.
Structural basis for substrate binding and catalytic mechanism of a human RNA m5C methyltransferase NSun6
Nucleic Acids Res.
45
6684-6697
2017
Schizosaccharomyces pombe (O13935), Schizosaccharomyces pombe (Q9HGQ2), Homo sapiens (Q8TEA1), Homo sapiens, Schizosaccharomyces pombe ATCC 24843 (O13935), Schizosaccharomyces pombe ATCC 24843 (Q9HGQ2), Schizosaccharomyces pombe 972 (O13935), Schizosaccharomyces pombe 972 (Q9HGQ2)
Yang, T.; Low, J.J.A.; Woon, E.C.Y.
A general strategy exploiting m5C duplex-remodelling effect for selective detection of RNA and DNA m5C methyltransferase activity in cells
Nucleic Acids Res.
48
e5
2020
Homo sapiens (O14717)
Gkatza, N.A.; Castro, C.; Harvey, R.F.; Heiss, M.; Popis, M.C.; Blanco, S.; Borneloev, S.; Sajini, A.A.; Gleeson, J.G.; Griffin, J.L.; West, J.A.; Kellner, S.; Willis, A.E.; Dietmann, S.; Frye, M.
Cytosine-5 RNA methylation links protein synthesis to cell metabolism
PLoS Biol.
17
e3000297
2019
Homo sapiens (O14717), Mus musculus (O55055)
Flores, J.V.; Cordero-Espinoza, L.; Oeztuerk-Winder, F.; Andersson-Rolf, A.; Selmi, T.; Blanco, S.; Tailor, J.; Dietmann, S.; Frye, M.
Cytosine-5 RNA methylation regulates neural stem cell differentiation and motility
Stem Cell Reports
8
112-124
2017
Homo sapiens (O14717), Mus musculus (O55055)
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