Reference on EC 2.1.1.2 - guanidinoacetate N-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cantoni, G.L.; Vignos, P.J.
Enzymatic mechanism of creatine synthesis
J. Biol. Chem.
209
647-659
1954
Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Sus scrofa
Im, Y.S.; Chiang, P.K.; Cantoni, G.L.
Guanidoacetate methyltransferase. Purification and molecular properties
J. Biol. Chem.
254
11047-11050
1979
Sus scrofa
Im, Y.S.; Cantoni, G.L.; Chiang, P.K.
A radioactive assay for guanidoacetate methyltransferase
Anal. Biochem.
95
87-88
1979
Sus scrofa
Ogawa, H.; Ishiguro, Y.; Fujioka, M.
Guanidoacetate methyltransferase from rat liver: purification, properties, and evidence for the involvement of sulfhydryl groups for activity
Arch. Biochem. Biophys.
226
265-275
1983
Rattus norvegicus
Ogawa, H.; Date, T.; Gomi, T.; Konishi, K.; Pitot, H.C.; Cantoni, G.L.; Fujioka, M.
Molecular cloning, sequence analysis, and expression in Escherichia coli of the cDNA for guanidinoacetate methyltransferase from rat liver
Proc. Natl. Acad. Sci. USA
85
694-698
1988
Rattus norvegicus
Fujioka, M.; Konishi, K.; Takata, Y.
Recombinant rat liver guanidinoacetate methyltransferase: reactivity and function of sulfhydryl groups
Biochemistry
27
7658-7664
1988
Rattus norvegicus
Konishi, K.; Fujioka, M.
Reversible inactivation of recombinant rat liver guanidinoacetate methyltransferase by glutathione disulfide
Arch. Biochem. Biophys.
289
90-96
1991
Rattus norvegicus
Takata, Y.; Fujioka, M.
Identification of a tyrosine residue in rat guanidinoacetate methyltransferase that is photolabeled with S-adenosyl-L-methionine
Biochemistry
31
4369-4374
1992
Rattus norvegicus
Lee, H.; Ogawa, H.; Fujioka, M.; Gerton, G.L.
Guanidinoacetate methyltransferase in the mouse: extensive expression in Sertoli cells of testis and in microvilli of caput epididymis
Biol. Reprod.
50
152-162
1994
Mus musculus
Takata, Y.; Konishi, K.; Gomi, T.; Fujioka, M.
Rat guanidinoacetate methyltransferase. Effect of site-directed alteration of an aspartic acid residue that is conserved across most mammalian S-adenosylmethionine-dependent methyltransferases
J. Biol. Chem.
269
5537-5542
1994
Rattus norvegicus (P10868)
Hamahata, A.; Takata, Y.; Gomi, T.; Fujioka, M.
Probing the S-adenosylmethionine-binding site of rat guanidinoacetate methyltransferase: effect of site-directed mutagenesis of residues that are conserved across mammalian non-nucleic acid methyltransferases
Biochem. J.
317
141-145
1996
Rattus norvegicus
-
Braissant, O.; Henry, H.; Loup, M.; Eilers, B.; Bachmann, C.
Endogenous synthesis and transport of creatine in the rat brain: an in situ hybridization study
Mol. Brain Res.
86
193-201
2001
Rattus norvegicus (P10868)
Komoto, J.; Huang, Y.; Takata, Y.; Yamada, T.; Konishi, K.; Ogawa, H.; Gomi, T.; Fujioka, M.; Takusagawa, F.
Crystal structure of guanidinoacetate methyltransferase from rat liver: A model structure of protein arginine methyltransferase
J. Mol. Biol.
320
223-235
2002
Rattus norvegicus
Komoto, J.; Takata, Y.; Yamada, T.; Konishi, K.; Ogawa, H.; Gomi, T.; Fujioka, M.; Takusagawa, F.
Monoclinic guanidinoacetate methyltransferase and gadolinium ion-binding characteristics
Acta Crystallogr. Sect. D
59
1589-1596
2003
Rattus norvegicus
Grazia Alessandri, M.; Celati, L.; Battini, R.; Baldinotti, F.; Item, C.; Leuzzi, V.; Cioni, G.
HPLC assay for guanidinoacetate methyltransferase
Anal. Biochem.
331
189-191
2004
Homo sapiens
Komoto, J.; Yamada, T.; Takata, Y.; Konishi, K.; Ogawa, H.; Gomi, T.; Fujioka, M.; Takusagawa, F.
Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes
Biochemistry
43
14385-14394
2004
Rattus norvegicus (P10868)
Tachikawa, M.; Fukaya, M.; Terasaki, T.; Ohtsuki, S.; Watanabe, M.
Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis
Eur. J. Neurosci.
20
144-160
2004
Mus musculus
Braissant, O.; Henry, H.; Villard, A.; Speer, O.; Wallimann, T.; Bachmann, C.
Creatine synthesis and transport during rat embryogenesis: Spatiotemporal expression of AGAT, GAMT and CT1
BMC Dev. Biol.
5
9
2005
Rattus norvegicus (P10868)
Velichkova, P.; Himo, F.
Theoretical study of the methyl transfer in guanidinoacetate methyltransferase
J. Phys. Chem. B
110
16-19
2006
Rattus norvegicus (P10868)
Leuzzi, V.; Carducci, C.; Carducci, C.; Matricardi, M.; Bianchi, M.C.; Di Sabato, M.L.; Artiola, C.; Antonozzi, I.
A mutation on exon 6 of guanidinoacetate methyltransferase (GAMT) gene supports a different function for isoform a and b of GAMT enzyme
Mol. Genet. Metab.
87
88-90
2006
Homo sapiens
Almeida, L.S.; Rosenberg, E.H.; Martinez-Munoz, C.; Verhoeven, N.M.; Vilarinho, L.; Jakobs, C.; Salomons, G.S.
Overexpression of GAMT restores GAMT activity in primary GAMT-deficient fibroblasts
Mol. Genet. Metab.
89
392-394
2006
Homo sapiens (Q14353), Homo sapiens
Zhang, X.; Bruice, T.C.
Reaction mechanism of guanidinoacetate methyltransferase, concerted or step-wise
Proc. Natl. Acad. Sci. USA
103
16141-16146
2006
Rattus norvegicus (P10868)
Wang, L.; Chen, D.; Zhang, Y.; Lin, Y.; Li, J.; Zhang, H.
Characterization of AGAT, GAMT and CT1 in amphioxus: implications for the evolutionary conservation of creatine metabolism related molecules at the invertebrate-to-vertebrate transition
Dev. Genes Evol.
218
681-689
2008
Branchiostoma belcheri (Q3S316)
Kan, H.E.; Meeuwissen, E.; van Asten, J.J.; Veltien, A.; Isbrandt, D.; Heerschap, A.
Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy
J. Appl. Physiol.
102
2121-2127
2007
Mus musculus
Schneider, J.E.; Stork, L.A.; Bell, J.T.; Hove, M.T.; Isbrandt, D.; Clarke, K.; Watkins, H.; Lygate, C.A.; Neubauer, S.
Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study
J. Cardiovasc. Magn. Reson.
10
1-9
2008
Mus musculus
Vodopiutz, J.; Item, C.B.; Haeusler, M.; Korall, H.; Bodamer, O.A.
Severe speech delay as the presenting symptom of guanidinoacetate methyltransferase deficiency
J. Child Neurol.
22
773-774
2007
Homo sapiens
Braissant, O.; Henry, H.
AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: A review
J. Inherit. Metab. Dis.
31
230-239
2008
Homo sapiens, Mus musculus
Verbruggen, K.T.; Sijens, P.E.; Schulze, A.; Lunsing, R.J.; Jakobs, C.; Salomons, G.S.; van Spronsen, F.J.
Successful treatment of a guanidinoacetate methyltransferase deficient patient: findings with relevance to treatment strategy and pathophysiology
Mol. Genet. Metab.
91
294-296
2007
Homo sapiens
Heerschap, A.; Kan, H.E.; Nabuurs, C.I.; Renema, W.K.; Isbrandt, D.; Wieringa, B.
In vivo magnetic resonance spectroscopy of transgenic mice with altered expression of guanidinoacetate methyltransferase and creatine kinase isoenzymes
Subcell. Biochem.
46
119-148
2007
Mus musculus
da Silva, R.P.; Nissim, I.; Brosnan, M.E.; Brosnan, J.T.
Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo
Am. J. Physiol. Endocrinol. Metab.
296
E256-E261
2009
Rattus norvegicus
Ireland, Z.; Russell, A.; Wallimann, T.; Walker, D.; Snow, R.
Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse
BMC Dev. Biol.
9
39
2009
Acomys cahirinus
Bera, S.; Wallimann, T.; Ray, S.; Ray, M.
Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells
FEBS J.
275
5899-5909
2008
Mus musculus
Brosnan, J.T.; Wijekoon, E.P.; Warford-Woolgar, L.; Trottier, N.L.; Brosnan, M.E.; Brunton, J.A.; Bertolo, R.F.
Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance
J. Nutr.
139
1292-1297
2009
Sus scrofa
Zhu, Y.; Prives, C.
p53 and Metabolism: The GAMT connection
Mol. Cell
36
351-352
2009
Mus musculus
Ide, T.; Brown-Endres, L.; Chu, K.; Ongusaha, P.P.; Ohtsuka, T.; El-Deiry, W.S.; Aaronson, S.A.; Lee, S.W.
GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress
Mol. Cell
36
379-392
2009
Homo sapiens, Mus musculus
Mercimek-Mahmutoglu, S.; Ndika, J.; Kanhai, W.; de Villemeur, T.B.; Cheillan, D.; Christensen, E.; Dorison, N.; Hannig, V.; Hendriks, Y.; Hofstede, F.C.; Lion-Francois, L.; Lund, A.M.; Mundy, H.; Pitelet, G.; Raspall-Chaure, M.; Scott-Schwoerer, J.A.; Szakszon, K.; Valayannopoulos, V.; William, M.; Salomons, G.S.
Thirteen new patients with guanidinoacetate methyltransferase deficiency and functional characterization of nineteen novel missense variants in the GAMT gene
Hum. Mutat.
35
462-469
2014
Homo sapiens (Q14353), Homo sapiens
Berends, L.M.; Struys, E.A.; Roos, B.; Holwerda, U.; Jansen, E.E.W.; Salomons, G.S.; Wamelink, M.M.C.
Guanidinoacetate methyltransferase activity in lymphocytes, for a fast diagnosis
JIMD Rep.
37
13-17
2017
Homo sapiens (Q14353), Homo sapiens
Tachikawa, M.; Watanabe, M.; Fukaya, M.; Sakai, K.; Terasaki, T.; Hosoya, K.I.
Cell-type-specific spatiotemporal expression of creatine biosynthetic enzyme S-adenosylmethionine guanidinoacetate N-methyltransferase in developing mouse brain
Neurochem. Res.
43
500-510
2018
Mus musculus (O35969)
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