Information on EC 2.1.1.194 - 23S rRNA (adenine2503-C2,C8)-dimethyltransferase

Old data from external sources may still be available.
Please check here for current data: EC 2.1.1.192

deleted, activity due to EC 2.1.1.192 (23S rRNA (adenine2503-C2)-methyltransferase) and EC 2.1.1.224 (23S rRNA (adenine2503-C8)-methyltransferase)

EC Tree 2 Transferases 2.1 Transferring one-carbon groups 2.1.1 Methyltransferases 2.1.1.194 23S rRNA (adenine2503-C2,C8)-dimethyltransferase

IUBMB Comments

Contains an [4Fe-S] cluster . Cfr is an plasmid-acquired methyltransferase that protects cells from the action of antibiotics . Cfr methylates position 2 of A²⁵⁰³ after the primary methylation at position 8 is complete . cf. 23S rRNA (adenine²⁵⁰³-C²)-methyltransferase (EC 2.1.1.192).

evolution

Escherichia coli

bioinformatics analysis of the Cfr/RlmN family establishes their significant evolutionary link with radical-S-adenosyl-L-methionine enzymes. The RlmN subfamily is likely the ancestral form, whereas the Cfr subfamily arose via duplication and horizontal gene transfer

705983

physiological function

3 entries