Reference on EC 2.1.1.192 - 23S rRNA (adenine2503-C2)-methyltransferase
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yan, F.; LaMarre, J.M.; Rhrich, R.; Wiesner, J.; Jomaa, H.; Mankin, A.S.; Fujimori, D.G.
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA
J. Am. Chem. Soc.
132
3953-3964
2010
Escherichia coli K-12 (P36979)
Toh, S.M.; Xiong, L.; Bae, T.; Mankin, A.S.
The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA
RNA
14
98-106
2008
Escherichia coli
LaMarre, J.M.; Howden, B.P.; Mankin, A.S.
Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance
Antimicrob. Agents Chemother.
55
2989-2991
2011
Staphylococcus aureus
Benitez-Paez, A.; Villarroya, M.; Armengod, M.E.
The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy
RNA
18
1783-1795
2012
Escherichia coli
Atkinson, G.C.; Hansen, L.H.; Tenson, T.; Rasmussen, A.; Kirpekar, F.; Vester, B.
Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase
Antimicrob. Agents Chemother.
57
4019-4026
2013
Escherichia coli, Bacillus subtilis (O34617), Thermus thermophilus (Q5SGZ3), Mammaliicoccus sciuri (Q9FBG4), Bacillus subtilis 168 (O34617), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SGZ3)
Silakov, A.; Grove, T.L.; Radle, M.I.; Bauerle, M.R.; Green, M.T.; Rosenzweig, A.C.; Boal, A.K.; Booker, S.J.
Characterization of a cross-linked protein-nucleic acid substrate radical in the reaction catalyzed by RlmN
J. Am. Chem. Soc.
136
8221-8228
2014
Escherichia coli
Grove, T.; Livada, J.; Schwalm, E.; Green, M.; Booker, S.; Silakov, A.
A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr
Nat. Chem. Biol.
9
422-427
2013
Staphylococcus aureus
Challand, M.R.; Salvadori, E.; Driesener, R.C.; Kay, C.W.; Roach, P.L.; Spencer, J.
Cysteine methylation controls radical generation in the Cfr radical AdoMet rRNA methyltransferase
PLoS ONE
8
e67979
2013
Mammaliicoccus sciuri (Q9FBG4)
Wang, C.; Yang, X.; Wang, E.; Li, B.
Quantum chemistry studies of adenosine 2503 methylation by S-adenosylmethionine-dependent enzymes
Int. J. Quantum Chem.
113
1409-1415
2013
Staphylococcus aureus
-
Gumkowski, J.D.; Martinie, R.J.; Corrigan, P.S.; Pan, J.; Bauerle, M.R.; Almarei, M.; Booker, S.J.; Silakov, A.; Krebs, C.; Boal, A.K.
Analysis of RNA methylation by phylogenetically diverse Cfr radical S-adenosylmethionine enzymes reveals an iron-binding accessory domain in a clostridial enzyme
Biochemistry
58
3169-3184
2019
Clostridioides difficile
Ntokou, E.; Hansen, L.; Kongsted, J.; Vester, B.
Biochemical and computational analysis of the substrate specificities of Cfr and RlmN Methyltransferases
PLoS ONE
10
e0145655
2015
Mammaliicoccus sciuri (A0A1X0U0N1), Escherichia coli (P36979)
Fitzsimmons, C.M.; Fujimori, D.G.
Determinants of tRNA recognition by the radical SAM enzyme RlmN
PLoS ONE
11
e0167298
2016
Escherichia coli, Escherichia coli (P36979)
Benitez-Paez, A.; Villarroya, M.; Armengod, M.-A.
The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy
RNA
18
1783-1795
2012
Escherichia coli (P36979), Escherichia coli
Boal, A.K.; Grove, T.L.; McLaughlin, M.I.; Yennawar, N.H.; Booker, S.J.; Rosenzweig, A.C.
Structural basis for methyl transfer by a radical SAM enzyme
Science
332
1089-1092
2011
Escherichia coli (P36979)
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