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IUBMB Comments The enzyme catalyses the methylation of guanosine2251
Reaction Schemes
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guanosine2251 in 23S rRNA
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2'-O-methylguanosine2251 in 23S rRNA
Synonyms
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23S rRNA methyltransferase
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rRNA Gm2251 methyltransferase
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S-adenosyl-L-methionine + guanosine2251 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
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S-adenosyl-L-methionine:23S rRNA (guanosine2251-2'-O)-methyltransferase
The enzyme catalyses the methylation of guanosine2251, a modification conserved in the peptidyltransferase domain of 23S rRNA.
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S-adenosyl-L-methionine + guanosine2251 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
S-adenosyl-L-methionine + guanosine2251 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
Substrates: the enzyme is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli
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S-adenosyl-L-methionine + guanosine2251 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
Substrates: -
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S-adenosyl-L-methionine + guanosine2251 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
Substrates: the enzyme is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli
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S-adenosyl-L-methionine
RlmB displays a AdoMet binding site located in the divergent C-terminal half of the catalytic domain
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SwissProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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malfunction
a DELTArlmB mutant lacks 2'-O-methylguanosine in 23S rRNA, the mutant does not show any ribosome assembly defects and is not outgrown by a wild-type strain even after 120 cell mass doublings
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sparse matrix screening by hanging drop vapor diffusion, crystal structure of this 2'O-methyltransferase has been determined at 2.5 A resolution
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additional information
a DELTArlmB mutant lacks 2'-O-methylguanosine in 23S rRNA, the mutant does not show any ribosome assembly defects and is not outgrown by a wild-type strain even after 120 cell mass doublings
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Lvgren, J.M.; Wikstrm, P.M.
The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli
J. Bacteriol.
183
6957-6960
2001
Escherichia coli (P63177)
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Michel, G.; Sauve, V.; Larocque, R.; Li, Y.; Matte, A.; Cygler, M.
The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot
Structure
10
1303-1315
2002
Escherichia coli (P63177), Escherichia coli
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