We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 2.1.1.185 - 23S rRNA (guanosine2251-2'-O)-methyltransferase for references in articles please use BRENDA:EC2.1.1.185Word Map on EC 2.1.1.185
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
The expected taxonomic range for this enzyme is: Escherichia coli
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
23S rRNA (guanosine2251-2'-O)-methyltransferase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + guanosine2251 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine:23S rRNA (guanosine2251-2'-O)-methyltransferase
The enzyme catalyses the methylation of guanosine2251, a modification conserved in the peptidyltransferase domain of 23S rRNA.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
23S rRNA methyltransferase
-
rRNA Gm2251 methyltransferase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
SwissProt
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
-
a DELTArlmB mutant lacks 2'-O-methylguanosine in 23S rRNA, the mutant does not show any ribosome assembly defects and is not outgrown by a wild-type strain even after 120 cell mass doublings
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + guanosine2251 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
S-adenosyl-L-methionine + guanosine2251 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
-
-
-
?
S-adenosyl-L-methionine + guanosine2251 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
the enzyme is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + guanosine2251 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
P63177
the enzyme is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine
-
RlmB displays a AdoMet binding site located in the divergent C-terminal half of the catalytic domain
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
sparse matrix screening by hanging drop vapor diffusion, crystal structure of this 2'O-methyltransferase has been determined at 2.5 A resolution
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
a DELTArlmB mutant lacks 2'-O-methylguanosine in 23S rRNA, the mutant does not show any ribosome assembly defects and is not outgrown by a wild-type strain even after 120 cell mass doublings
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Lövgren, J.M.; Wikström, P.M.
The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli
J. Bacteriol.
183
6957-6960
2001
Escherichia coli (P63177)
brenda
Michel, G.; Sauve, V.; Larocque, R.; Li, Y.; Matte, A.; Cygler, M.
The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot
Structure
10
1303-1315
2002
Escherichia coli, Escherichia coli (P63177)
brenda
html completed