Reference on EC 2.1.1.182 - 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Formenoy, L.J.; Cunningham, P.R.; Nurse, K.; Pleij, C.W.A.; Ofengand, J.
Methylation of the conserved A1518-A1519 in Escherichia coli 16S ribosomal RNA by the ksgA methyltransferase is influenced by methylations around the similarly conserved U1512-G1523 base pair in the 3' terminal hairpin
Biochimie
76
1123-1128
1994
Escherichia coli
Manually annotated by BRENDA team
O'Farrell, H.C.; Scarsdale, J.N.; Rife, J.P.
Crystal structure of KsgA, a universally conserved rRNA adenine dimethyltransferase in Escherichia coli
J. Mol. Biol.
339
337-353
2004
Escherichia coli (P06992)
Manually annotated by BRENDA team
Ochi, K.; Kim, J.Y.; Tanaka, Y.; Wang, G.; Masuda, K.; Nanamiya, H.; Okamoto, S.; Tokuyama, S.; Adachi, Y.; Kawamura, F.
Inactivation of KsgA, a 16S rRNA methyltransferase, causes vigorous emergence of mutants with high-level kasugamycin resistance
Antimicrob. Agents Chemother.
53
193-201
2009
Bacillus subtilis
Manually annotated by BRENDA team
Desai, P.M.; Rife, J.P.
The adenosine dimethyltransferase KsgA recognizes a specific conformational state of the 30S ribosomal subunit
Arch. Biochem. Biophys.
449
57-63
2006
Escherichia coli
Manually annotated by BRENDA team
Cunningham, P.R.; Weitzmann, C.J.; Nurse, K.; Masurel, R.; van Knippenberg, P.H.; Ofengand, J.
Site-specific mutation of the conserved m6(2)A m6(2)A residues of E. coli 16S ribosomal RNA. Effects on ribosome function and activity of the ksgA methyltransferase
Biochim. Biophys. Acta
1050
18-26
1990
Escherichia coli
Manually annotated by BRENDA team
Binet, R.; Maurelli, A.T.
The chlamydial functional homolog of KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness
BMC Microbiol.
9
0000
2009
Chlamydia psittaci (C7EP45), Chlamydia psittaci 6BC (C7EP45), Chlamydia trachomatis (B0B7S3), Chlamydia trachomatis L2 (B0B7S3)
Manually annotated by BRENDA team
van Buul, C.P.; van Knippenberg, P.H.
Nucleotide sequence of the ksgA gene of Escherichia coli: comparison of methyltransferases effecting dimethylation of adenosine in ribosomal RNA
Gene
38
65-72
1985
Escherichia coli (P06992)
Manually annotated by BRENDA team
Duffin, P.M.; Seifert, H.S.
ksgA mutations confer resistance to kasugamycin in Neisseria gonorrhoeae
Int. J. Antimicrob. Agents
33
321-327
2009
Neisseria gonorrhoeae
Manually annotated by BRENDA team
Inoue, K.; Basu, S.; Inouye, M.
Dissection of 16S rRNA methyltransferase (KsgA) function in Escherichia coli
J. Bacteriol.
189
8510-8518
2007
Escherichia coli
Manually annotated by BRENDA team
Poldermans, B.; Roza, L.; van Knippenberg, P.H.
Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16 S ribosomal RNA of Escherichia coli. III. Purification and properties of the methylating enzyme and methylase-30 S interactions
J. Biol. Chem.
254
9094-9100
1979
Escherichia coli
Manually annotated by BRENDA team
Lafontaine, D.; Delcour, J.; Glasser, A.L.; Desgres, J.; Vandenhaute, J.
The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast
J. Mol. Biol.
241
492-497
1994
Escherichia coli
Manually annotated by BRENDA team
Demirci, H.; Belardinelli, R.; Seri, E.; Gregory, S.T.; Gualerzi, C.; Dahlberg, A.E.; Jogl, G.
Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine
J. Mol. Biol.
388
271-282
2009
Thermus thermophilus (Q5SM60), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SM60)
Manually annotated by BRENDA team
Andresson, O.S.; Davies, J.E.
Some properties of the ribosomal RNA methyltransferase encoded by ksgA and the polarity of ksgA transcription
Mol. Gen. Genet.
179
217-222
1980
Escherichia coli
Manually annotated by BRENDA team
Connolly, K.; Rife, J.P.; Culver, G.
Mechanistic insight into the ribosome biogenesis functions of the ancient protein KsgA
Mol. Microbiol.
70
1062-1075
2008
Escherichia coli (P06992)
Manually annotated by BRENDA team
Helser, T.L.; Davies, J.E.; Dahlberg, J.E.
Change in methylation of 16S ribosomal RNA associated with mutation to kasugamycin resistance in Escherichia coli
Nat. New Biol.
233
12-14
1971
Escherichia coli
Manually annotated by BRENDA team
Helser, T.L.; Davies, J.E.; Dahlberg, J.E.
Mechanism of kasugamycin resistance in Escherichia coli
Nat. New Biol.
235
6-9
1972
Escherichia coli
Manually annotated by BRENDA team
Zhang-Akiyama, Q.M.; Morinaga, H.; Kikuchi, M.; Yonekura, S.; Sugiyama, H.; Yamamoto, K.; Yonei, S.
KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli
Nucleic Acids Res.
37
2116-2125
2009
Escherichia coli (P06992)
Manually annotated by BRENDA team
O'Farrell, H.C.; Pulicherla, N.; Desai, P.M.; Rife, J.P.
Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution
RNA
12
725-733
2006
Escherichia coli
Manually annotated by BRENDA team
Tu, C.; Tropea, J.E.; Austin, B.P.; Court, D.L.; Waugh, D.S.; Ji, X.
Structural basis for binding of RNA and cofactor by a KsgA methyltransferase
Structure
17
374-385
2009
Aquifex aeolicus, Aquifex aeolicus (O67680)
Manually annotated by BRENDA team
O'Farrell, H.C.; Musayev, F.N.; Scarsdale, J.N.; Rife, J.P.
Control of substrate specificity by a single active site residue of the KsgA methyltransferase
Biochemistry
51
466-474
2012
Escherichia coli
Manually annotated by BRENDA team
Kyuma, T.; Kizaki, H.; Ryuno, H.; Sekimizu, K.; Kaito, C.
16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus
Biochimie
119
166-174
2015
Staphylococcus aureus, Staphylococcus aureus RN4220
Manually annotated by BRENDA team
Phunpruch, S.; Warit, S.; Suksamran, R.; Billamas, P.; Jaitrong, S.; Palittapongarnpim, P.; Prammananan, T.
A role for 16S rRNA dimethyltransferase (ksgA) in intrinsic clarithromycin resistance in Mycobacterium tuberculosis
Int. J. Antimicrob. Agents
41
548-551
2013
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team