show all | hide all No of entries

Information on EC 2.1.1.180 - 16S rRNA (adenine1408-N1)-methyltransferase and Organism(s) Streptoalloteichus hindustanus and UniProt Accession Q2MEY3

for references in articles please use BRENDA:EC2.1.1.180
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N1-methylation at position adenine1408 .
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Streptoalloteichus hindustanus
UNIPROT: Q2MEY3
Word Map
  • 2.1.1.180
  • trna
  • microcephaly
  • disability
  • intellectual
  • spout
  • purine
  • aminoglycoside
  • stature
  • guanosine
  • exome
  • eukaryal
  • circumference
  • monogenic
  • post-transcriptionally
  • puberty
  • guanosine-specific
  • islet
  • cdkal1
  • methylthiotransferase
  • adenosine-specific
The taxonomic range for the selected organisms is: Streptoalloteichus hindustanus
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
Synonyms
16S rRNA (m1A1408) methyltransferase, 16S rRNA m1A1408 methyltransferase, 16S rRNA:m(1)A1408 methyltransferase, A1408 16S rRNA methyltransferase, KAM, KamB, kanamycin-apramycin resistance methylase, Kmr, m1A1408, Npm, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
16S rRNA:m(1)A1408 methyltransferase
290062
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:16S rRNA (adenine1408-N1)-methyltransferase
The enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N1-methylation at position adenine1408 [4].
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
microorganisms that produce aminoglycosides have developed a special mechanism of high level resistance by posttranscriptional methylation of 16S rRNA in the aminoglycoside binding site. N1-methylation of A1408 confers resistance to kanamycin, tobramycin, sisomycin and apramycin, but not to gentamycin. The M1A1408 methylation is carried out by methyltransferases from the Kam family
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KAMB_STRHI
215
0
23670
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
gene sequence is used for protein structure prediction, model of ShKamB
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Koscinski, L.; Feder, M.; Bujnicki, J.M.
Identification of a missing sequence and functionally important residues of 16S rRNA:m(1)A1408 methyltransferase KamB that causes bacterial resistance to aminoglycoside antibiotics
Cell Cycle
6
1268-1271
2007
Streptoalloteichus hindustanus (Q2MEY3)
Manually annotated by BRENDA team
Select items on the left to see more content.