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Information on EC 2.1.1.180 - 16S rRNA (adenine1408-N1)-methyltransferase

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IUBMB Comments
The enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N1-methylation at position adenine1408 .
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Word Map
  • 2.1.1.180
  • trna
  • microcephaly
  • disability
  • intellectual
  • spout
  • purine
  • aminoglycoside
  • stature
  • guanosine
  • exome
  • eukaryal
  • circumference
  • monogenic
  • post-transcriptionally
  • puberty
  • guanosine-specific
  • islet
  • cdkal1
  • methylthiotransferase
  • adenosine-specific
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
16S rRNA (m1A1408) methyltransferase, 16S rRNA m1A1408 methyltransferase, 16S rRNA:m(1)A1408 methyltransferase, A1408 16S rRNA methyltransferase, KAM, KamB, kanamycin-apramycin resistance methylase, m1A1408, NpmA, plasmid-mediated 16S rRNA methyltransferase A, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + adenine1408 in 16S rRNA = S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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