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Information on EC 2.1.1.167 - 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase and Organism(s) Agaricus bisporus and UniProt Accession P25582

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IUBMB Comments
Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922, a universally conserved position of the catalytic center of the ribosome that is essential for translation. 2'-O-Methylguanosine2922 is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA. In absence of snR52, Spb1p can also catalyse the formation of uridine2921 .
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Agaricus bisporus
UNIPROT: P25582
Word Map
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The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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S-adenosyl-L-methionine
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guanosine2922 in 27S pre-rRNA
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S-adenosyl-L-homocysteine
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2'-O-methylguanosine2922 in 27S pre-rRNA
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guanosine2922 in 27S pre-rRNA
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2'-O-methylguanosine2922 in 27S pre-rRNA
Synonyms
Spb1p, more
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:27S pre-rRNA (guanosine2922-2'-O)-methyltransferase
Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922, a universally conserved position of the catalytic center of the ribosome that is essential for translation. 2'-O-Methylguanosine2922 is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA. In absence of snR52, Spb1p can also catalyse the formation of uridine2921 [1].
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