Reference on EC 2.1.1.160 - caffeine synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Koshiishi, C.; Kato, A.; Yama, S.; Crozier, A.; Ashihara, H.
A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S-adenosyl-L-methionine cycle
FEBS Lett.
499
50-54
2001
Camellia sinensis
McCarthy, A.A.; Biget, L.; Lin, C.; Petiard, V.; Tanksley, S.D.; McCarthy, J.G.
Cloning, expression, crystallization and preliminary x-ray analysis of the XMT and DXMT N-methyltransferases from Coffea canephora (robusta)
Acta Crystallogr. Sect. F
F63
304-307
2007
Coffea canephora (A4GE70)
Mizuno, K.; Okuda, A.; Kato, M.; Yoneyama, N.; Tanaka, H.; Ashihara, H.; Fujimura, T.
Isolation of a new dual-functional caffeine synthase gene encoding an enzyme for the conversion of 7-methylxanthine to caffeine from coffee (Coffea arabica L.)
FEBS Lett.
534
75-81
2003
Coffea arabica (Q8H0D3)
Ogawa, M.; Herai, Y.; Koizumi, N.; Kusano, T.; Sano, H.
7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties
J. Biol. Chem.
276
8213-8218
2001
Coffea arabica (Q9AVJ9)
Yoneyama, N.; Morimoto, H.; Ye, C.X.; Ashihara, H.; Mizuno, K.; Kato, M.
Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme
Mol. Genet. Genomics
275
125-135
2006
Camellia ptilophylla (Q2HXI6), Theobroma cacao (Q2HXL8), Camellia irrawadiensis (Q2HXL9)
Kato, M.; Mizuno, K.; Crozier, A.; Fujimura, T.; Ashihara, H.
Caffeine synthase gene from tea leaves
Nature
406
956-957
2000
Camellia sinensis (Q9FZN8), Camellia sinensis
Roberts, M.F.; Waller, G.R.
N-methyltransferases and 7-methyl-N9-nucleoside hydrolase activity in Coffea arabica and the biosynthesis of caffeine
Phytochemistry
18
451-455
1979
Coffea arabica
-
Waldhauser, S.S.M.; Gillies, F.M.; Crozier, A.; Baumann, T.W.
Separation of the N-7 methyltransferase, the key enzyme in caffeine biosynthesis
Phytochemistry
45
1407-1414
1997
Coffea arabica
Ogita, S.; Uefuji, H.; Morimoto, M.; Sano, H.
Application of RNAi to confirm theobromine as the major intermediate for caffeine biosynthesis in coffee plants with potential for construction of decaffeinated varieties
Plant Mol. Biol.
54
931-941
2004
Coffea canephora, Coffea arabica (Q8H0D2)
Uefuji, H.; Tatsumi, Y.; Morimoto, M.; Kaothien-Nakayama, P.; Ogita, S.; Sano, H.
Caffeine production in tobacco plants by simultaneous expression of three coffee N-methyltranferases and its potential as a pest repellant
Plant Mol. Biol.
59
221-227
2005
Coffea arabica (Q8H0D2)
Kato, M.; Mizuno, K.; Fujimura, T.; Iwama, M.; Irie, M.; Crozier, A.; Ashihara, H.
Purification and characterization of caffeine synthase from tea leaves
Plant Physiol.
120
579-586
1999
Camellia sinensis
Uefuji, H.; Ogita, S.; Yamaguchi, Y.; Koizumi, N.; Sano, H.
Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants
Plant Physiol.
132
372-380
2003
Coffea arabica (Q8H0D2)
McCarthy, A.A.; McCarthy, J.G.
The structure of two N-methyltransferases from the caffeine biosynthetic pathway
Plant Physiol.
144
879-889
2007
Coffea canephora (A4GE70)
Koshiro, Y.; Zheng, X.Q.; Wang, M.L.; Nagai, C.; Ashihara, H.
Changes in content and biosynthetic activity of caffeine and trigonelline during growth and ripening of Coffea arabica and Coffea canephora fruits
Plant Sci.
171
242-250
2006
Coffea canephora, Coffea arabica (Q8H0D3), Coffea canephora CCS1
McCarthy, A.A.; Biget, L.; Lin, C.; Petiard, V.; Tanksley, S.D.; McCarthy, J.G.
Cloning, expression, crystallization and preliminary X-ray analysis of the XMT and DXMT N-methyltransferases from Coffea canephora (robusta)
Acta Crystallogr. Sect. F
63
304-307
2007
Coffea canephora (A4GE70)
Li, Y.; Gu, W.; Ye, S.
Expression and location of caffeine synthase in tea plants
Russ. J. Plant Physiol.
54
698-701
2007
Camellia sinensis (Q9FZN8)
-
Kodama, Y.; Shinya, T.; Sano, H.
Dimerization of N-methyltransferases involved in caffeine biosynthesis
Biochimie
90
547-551
2008
Coffea arabica
Maluf, M.; Da Silva, C.; De Oliveira, M.; Tavares, A.; Silvarolla, M.; Guerreiro Filho, O.
Altered expression of the caffeine synthase gene in a naturally caffeine-free mutant of Coffea arabica
Genet. Mol. Biol.
32
802-810
2009
Coffea arabica (Q8H0D3), Coffea arabica
Mohanpuria, P.; Kumar, V.; Joshi, R.; Gulati, A.; Ahuja, P.S.; Yadav, S.K.
Caffeine biosynthesis and degradation in tea [Camellia sinensis (L.) O. Kuntze] is under developmental and seasonal regulation
Mol. Biotechnol.
43
104-111
2009
Camellia sinensis
Li, Y.; Ogita, S.; Keya, C.; Ashihara, H.
Expression of caffeine biosynthesis genes in tea (Camellia sinensis)
Z. Naturforsch. C
63
267-270
2008
Camellia sinensis (Q9FZN8), Camellia sinensis
Mohanpuria, P.; Kumar, V.; Ahuja, P.S.; Yadav, S.K.
Agrobacterium-mediated silencing of caffeine synthesis through root transformation in Camellia sinensis L.
Mol. Biotechnol.
48
235-243
2011
Camellia sinensis (B9VI89), Camellia sinensis
Mohanpuria, P.; Kumar, V.; Ahuja, P.S.; Yadav, S.K.
Producing low-caffeine tea through post-transcriptional silencing of caffeine synthase mRNA
Plant Mol. Biol.
76
523-534
2011
Camellia sinensis
Kato, M.; Kitao, N.; Ishida, M.; Morimoto, H.; Irino, F.; Mizuno, K.
Expression for caffeine biosynthesis and related enzymes in Camellia sinensis
Z. Naturforsch. C
65c
245-256
2010
Camellia sinensis
Mizuno, K.; Kurosawa, S.; Yoshizawa, Y.; Kato, M.
Essential region for 3-N methylation in N-methyltransferases involved in caffeine biosynthesis
Z. Naturforsch. C
65c
257-265
2010
Coffea sp.
Mizuno, K.; Matsuzaki, M.; Kanazawa, S.; Tokiwano, T.; Yoshizawa, Y.; Kato, M.
Conversion of nicotinic acid to trigonelline is catalyzed by N-methyltransferase belonged to motif B methyltransferase family in Coffea arabica
Biochem. Biophys. Res. Commun.
452
1060-1066
2014
Coffea arabica (Q8H0D3), Coffea arabica
Deng, W.W.; Li, M.; Gu, C.C.; Li, D.X.; Ma, L.L.; Jin, Y.; Wan, X.C.
Low caffeine content in novel grafted tea with Camellia sinensis as scions and Camellia oleifera as stocks
Nat. Prod. Commun.
10
789-792
2015
Camellia sinensis (Q9FZN8), Camellia sinensis
Jin, J.; Yao, M.; Ma, C.; Ma, J.; Chen, L.
Natural allelic variations of TCS1 play a crucial role in caffeine biosynthesis of tea plant and its related species
Plant Physiol. Biochem.
100
18-26
2016
Camellia sinensis (K9MNV5), Camellia sinensis
Jin, L.; Bhuiya, M.W.; Li, M.; Liu, X.; Han, J.; Deng, W.; Wang, M.; Yu, O.; Zhang, Z.
Metabolic engineering of Saccharomyces cerevisiae for caffeine and theobromine production
PLoS ONE
9
e105368
2014
Camellia sinensis (Q9FZN8), Camellia sinensis
Pech-Ku, R.; Munoz-Sanchez, J.A.; Monforte-Gonzalez, M.; Vazquez-Flota, F.; Rodas-Junco, B.A.; Hernandez-Sotomayor, S.M.T.
Caffeine extraction, enzymatic activity and gene expression of caffeine synthase from plant cell suspensions
J. Vis. Exp.
140
e58166
2018
Coffea arabica (Q8H0D3)
Schimpl, F.C.; Kiyota, E.; Mazzafera, P.
Production of recombinant caffeine synthase from guarana (Paullinia cupana var. sorbilis) in Escherichia coli
Methods Mol. Biol.
1405
49-57
2016
Paullinia cupana var. sorbilis (A0A061DEC0)
Kumar, A.; Giridhar, P.
Salicylic acid and methyljasmonate restore the transcription of caffeine biosynthetic N-methyltransferases from a transcription inhibition noticed during late endosperm maturation in coffee
Plant Gene
4
38-44
2015
Coffea canephora (A4GE70), Coffea canephora var. robusta (A4GE70)
-
Li, M.; Sun, Y.; Pan, S.; Deng, W.; Yu, O.; Zhang, Z.
Engineering a novel biosynthetic pathway in Escherichia coli for the production of caffeine
RSC Adv.
7
56382-56389
2017
Camellia sinensis (Q9FZN8)
-
Liu, Y.; Jin, J.; Yao, M.; Chen, L.
Screening, cloning and functional research of the rare allelic variation of caffeine synthase gene (TCS1G) in tea plants
Sci. Agric. Sin.
52
1772-1783
2019
Camellia taliensis
-
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