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S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
additional information
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S-adenosyl-L-methionine + xanthosine

S-adenosyl-L-homocysteine + 7-methylxanthosine
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S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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the enzyme is part of a caffeine biosynthetic pathway which includes a recycling of adenosine released from S-adenosyl-L-methionine in form of xanthosine monophosphate, overview
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S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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first step in caffeine biosynthesis
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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first step in caffeine biosynthesis pathway from xanthosine
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?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
first step in caffeine biosynthesis pathway from xanthosine
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
first step in caffeine biosynthesis pathway from xanthosine, reduction of the second enzyme of the pathway, 7-methylxanthine methyltransferase, EC 2.1.1.159, leads to reduced XMT1 expression
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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in vivo feeding experiments with radio-labeled substrate, product determination, overview
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
step of the caffeine biosynthesis, caffeine accumulation in seeds
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?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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specific methylation at N-7 position
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
the enzyme is specific for xanthosine
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?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
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?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
first step in caffeine biosynthesis pathway from xanthosine, reduction of the second enzyme of the pathway, 7-methylxanthine methyltransferase, EC 2.1.1.159, leads to reduced XMT1 expression
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
step of the caffeine biosynthesis, caffeine accumulation in seeds
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?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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-
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?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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step of the caffeine biosynthesis, caffeine accumulation in seeds
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?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
Coffea sp.
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additional information

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enzyme expression and activity during caffeine biosynthesis in fruits, overview
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additional information
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substrate specificity of the recombinant His-tagged enzyme, no activity with xanthosine 5'-phosphate, theobromine, or 7-methylxanthosine
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additional information
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enzyme expression and activity during caffeine biosynthesis in fruits, overview
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additional information
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both xanthosine and its monoanionic form with N3 deprotonated are used as the substrates for the methylation. While the methyl group can be transferred to the monoanionic form of xanthosine with a reasonable free energy barrier (about 17 kcal/mol), this is not the case for the neutral xanthosine (barrier is about 31 kcal/mol). The hydrogen bonding and hydrophobic interactions involving the monoanionic form closely represent the corresponding interactions in the crystal structure, which seems not to be the case for the reactant complex involving the neutral xanthosine
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additional information
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enzyme expression and activity during caffeine biosynthesis in fruits, overview
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additional information
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Coffea sp.
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7-methylxanthosine synthase shows the most critical substrate specifi city of the three types of N-methyltransferases in Coffea species
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S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
additional information
?
-
S-adenosyl-L-methionine + xanthosine

S-adenosyl-L-homocysteine + 7-methylxanthosine
-
the enzyme is part of a caffeine biosynthetic pathway which includes a recycling of adenosine released from S-adenosyl-L-methionine in form of xanthosine monophosphate, overview
-
-
?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
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?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
-
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
first step in caffeine biosynthesis
-
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ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
first step in caffeine biosynthesis pathway from xanthosine
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?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
first step in caffeine biosynthesis pathway from xanthosine
-
-
ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
first step in caffeine biosynthesis pathway from xanthosine, reduction of the second enzyme of the pathway, 7-methylxanthine methyltransferase, EC 2.1.1.159, leads to reduced XMT1 expression
-
-
ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
in vivo feeding experiments with radio-labeled substrate, product determination, overview
-
-
ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
step of the caffeine biosynthesis, caffeine accumulation in seeds
-
-
?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
-
-
ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
first step in caffeine biosynthesis pathway from xanthosine, reduction of the second enzyme of the pathway, 7-methylxanthine methyltransferase, EC 2.1.1.159, leads to reduced XMT1 expression
-
-
ir
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
step of the caffeine biosynthesis, caffeine accumulation in seeds
-
-
?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
-
step of the caffeine biosynthesis, caffeine accumulation in seeds
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-
?
S-adenosyl-L-methionine + xanthosine
S-adenosyl-L-homocysteine + 7-methylxanthosine
Coffea sp.
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?
additional information

?
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enzyme expression and activity during caffeine biosynthesis in fruits, overview
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-
?
additional information
?
-
-
enzyme expression and activity during caffeine biosynthesis in fruits, overview
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-
?
additional information
?
-
-
enzyme expression and activity during caffeine biosynthesis in fruits, overview
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Asthma
Biochemical studies of N-methyltransferase in human and guinea-pig lung: no apparent role in the pathogenesis of asthma.
Asthma
No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations.
Asthma
[Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma.]
Brachydactyly
Novel PRMT7 mutation in a rare case of dysmorphism and intellectual disability.
Breast Neoplasms
FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.
Breast Neoplasms
Inhibition of euchromatin histone-lysine N-methyltransferase 2 sensitizes breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through reactive oxygen species-mediated activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway activation.
Carcinogenesis
Aberrant Activity of Histone-Lysine N-Methyltransferase 2 (KMT2) Complexes in Oncogenesis.
Carcinogenesis
Downregulation of histone-lysine N-methyltransferase EZH2 inhibits cell viability and enhances chemosensitivity in lung cancer cells.
Carcinogenesis
Genomic alterations in KMT2 family predict outcome of immune checkpoint therapy in multiple cancers.
Carcinogenesis
In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.
Carcinogenesis
Molecular signature of interleukin-22 in colon carcinoma cells and organoid models.
Carcinogenesis
Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma.
Carcinogenesis
Reduced expression of SETD2 and SNX9 proteins in chemically induced mammary tumorigenesis in Wistar rats: a prognostic histological and proteomic study.
Carcinoma
Molecular signature of interleukin-22 in colon carcinoma cells and organoid models.
Carcinoma, Hepatocellular
Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform.
Carcinoma, Hepatocellular
Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
[Comparison of the expression and activity of phosphatidylethanolamine N-methyltransferase 2 between primary cultured hepatocytes and hepatoma cells in rats]
Colitis
Protein Arginine Methyltransferase 5 Inhibition Upregulates Foxp3(+) Regulatory T Cells Frequency and Function during the Ulcerative Colitis.
Colorectal Neoplasms
Histone-lysine N-methyltransferase SETD7 is a potential serum biomarker for colorectal cancer patients.
Coronary Artery Disease
Association of the histone-lysine N-methyltransferase MLL5 gene with coronary artery disease in Chinese Han people.
Diabetic Retinopathy
Proteomic analysis of retinopathy-related plasma biomarkers in diabetic patients.
Hearing Loss, Sensorineural
Studying the Association between Sudden Hearing Loss and DNA N-Methyltransferase 1 (DNMT1) Genetic Polymorphism.
Hearing Loss, Sudden
Studying the Association between Sudden Hearing Loss and DNA N-Methyltransferase 1 (DNMT1) Genetic Polymorphism.
Infections
A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity.
Infections
Downregulation of histone methyltransferase EHMT2 in CD4(+) T-cells may protect HTLV-1-infected individuals against HAM/TSP development.
Influenza, Human
Evidence for a novel mechanism of influenza A virus host adaptation modulated by PB2-627.
Leukemia
MLL/KMT2A translocations in diffuse large B-cell lymphomas.
Leukemia
MLL5 (KMT2E): structure, function, and clinical relevance.
Leukemia
Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.
Leukemia
Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells.
Leukemia, Myeloid, Acute
DNMT3A mutants provide proliferating advantage with augmentation of self-renewal activity in the pathogenesis of AML in KMT2A-PTD-positive leukemic cells.
Leukemia, Myeloid, Acute
The Application of Targeted RNA Sequencing for KMT2A-Partial Tandem Duplication Identification and Integrated Analysis of Molecular Characterization in Acute Myeloid Leukemia.
Liver Diseases
Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide.
Lordosis
Inhibition of guinea pig lordosis behavior by the phenylethanolamine N-methyltransferase (PNMT) inhibitor SKF-64139: mediation by alpha noradrenergic receptors.
Lung Injury
Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia.
Lung Neoplasms
Downregulation of histone-lysine N-methyltransferase EZH2 inhibits cell viability and enhances chemosensitivity in lung cancer cells.
Neoplasm Metastasis
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Neoplasm Metastasis
Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform.
Neoplasm Metastasis
Preprogramming therapeutic response of PI3K/mTOR dual inhibitor via the regulation of EHMT2 and p27 in pancreatic cancer.
Neoplasm Metastasis
Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells.
Neoplasms
A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity.
Neoplasms
Accumulation of low-dose BIX01294 promotes metastatic potential of U251 glioblastoma cells.
Neoplasms
Comprehensive Cancer Panel Sequencing Defines Genetic Diversity and Changes in the Mutational Characteristics of Pancreatic Cancer Patients Receiving Neoadjuvant Treatment.
Neoplasms
Computational discovery and biological evaluation of novel inhibitors targeting histone-lysine N-methyltransferase SET7.
Neoplasms
Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling.
Neoplasms
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.
Neoplasms
Downregulation of histone-lysine N-methyltransferase EZH2 inhibits cell viability and enhances chemosensitivity in lung cancer cells.
Neoplasms
Epigenetic priming by EHMT1/EHMT2 in acute lymphoblastic leukemia induces TP53 and TP73 overexpression and promotes cell death.
Neoplasms
Genomic alterations in KMT2 family predict outcome of immune checkpoint therapy in multiple cancers.
Neoplasms
Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays.
Neoplasms
Identification of protein arginine N-methyltransferase 5 (PRMT5) as a novel interacting protein with the tumor suppressor protein RASSF1A.
Neoplasms
Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks.
Neoplasms
Increased expression of G9A contributes to carcinogenesis and indicates poor prognosis in hepatocellular carcinoma.
Neoplasms
Inhibition of euchromatin histone-lysine N-methyltransferase 2 sensitizes breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through reactive oxygen species-mediated activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway activation.
Neoplasms
Integration of comprehensive genomic profiling, tumor mutational burden, and PD-L1 expression to identify novel biomarkers of immunotherapy in non-small cell lung cancer.
Neoplasms
MLL/KMT2A translocations in diffuse large B-cell lymphomas.
Neoplasms
Morphology, Biochemistry, and Pathophysiology of MENX-Related Pheochromocytoma Recapitulate the Clinical Features.
Neoplasms
Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats.
Neoplasms
Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells.
Neoplasms
Reduced expression of SETD2 and SNX9 proteins in chemically induced mammary tumorigenesis in Wistar rats: a prognostic histological and proteomic study.
Neoplasms
Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells.
Neoplasms
RNAi-mediated EZH2 depletion decreases MDR1 expression and sensitizes multidrug-resistant hepatocellular carcinoma cells to chemotherapy.
Neoplasms
Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.
Neoplasms
The Promise for Histone Methyltransferase Inhibitors for Epigenetic Therapy in Clinical Oncology: A Narrative Review.
Neoplasms
The tumor suppressor DAL-1/4.1B modulates protein arginine N-methyltransferase 5 activity in a substrate-specific manner.
Neoplasms
Up-regulated long non-coding RNA DUXAP8 promotes cell growth through repressing Krüppel-like factor 2 expression in human hepatocellular carcinoma.
Neoplasms
Wedelolactone Targets EZH2-mediated Histone H3K27 Methylation in Mantle Cell Lymphoma.
Neuroblastoma
EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells.
Ovarian Neoplasms
Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress.
Pancreatic Neoplasms
KMT2D deficiency enhances the anti-cancer activity of L48H37 in pancreatic ductal adenocarcinoma.
Pancreatic Neoplasms
Preprogramming therapeutic response of PI3K/mTOR dual inhibitor via the regulation of EHMT2 and p27 in pancreatic cancer.
Paralysis
Asymmetric dimethylarginine exacerbates A?-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.
Parkinson Disease
(R)salsolinol N-methyltransferase activity increases in parkinsonian lymphocytes.
Parkinson Disease
A neutral N-methyltransferase activity in the striatum determines the level of an endogenous MPP+-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains.
Parkinson Disease
Characterization of brain beta-carboline-2-N-methyltransferase, an enzyme that may play a role in idiopathic Parkinson's disease.
Parkinson Disease
Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease.
Parkinson Disease
Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: occurrence, metabolism and function in human brains.
Parkinson Disease
Increased beta-carboline 9N-methyltransferase activity in the frontal cortex in Parkinson's disease.
Parkinson Disease
Involvement of endogenous N-methyl(R)salsolinol in Parkinson's disease: induction of apoptosis and protection by (-)deprenyl.
Parkinson Disease
N-methyl(R)salsolinol and a neutral N-methyltransferase as pathogenic factors in Parkinson's disease.
Pneumonia
Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia.
Prader-Willi Syndrome
Epigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Prader-Willi Syndrome.
Prostatic Neoplasms
EHMT2 promotes the development of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
Prostatic Neoplasms
Small molecule inhibitors of the prostate cancer target KMT2D.
Sarcoma
The Promise for Histone Methyltransferase Inhibitors for Epigenetic Therapy in Clinical Oncology: A Narrative Review.
Seizures
Novel PRMT7 mutation in a rare case of dysmorphism and intellectual disability.
Seizures
The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats.
Starvation
Changes in histamine metabolism in the brains of mice with streptozotocin-induced diabetes.
Stomach Neoplasms
Large-scale analysis of KMT2 mutations defines a distinctive molecular subset with treatment implication in gastric cancer.
Thymoma
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis.
Urinary Bladder Neoplasms
Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer.
Urinary Bladder Neoplasms
EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells.
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