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Information on EC - glycine/sarcosine N-methyltransferase

for references in articles please use BRENDA:EC2.1.1.156
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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
       glycine/sarcosine N-methyltransferase
IUBMB Comments
Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC, sarcosine/dimethylglycine N-methyltransferase. Differs from EC, glycine N-methyltransferase, as it can further methylate the product of the first reaction. Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction .
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
glycine sarcosine dimethylglycine methyltransferase, glycine sarcosine methyltransferase, glycine sarcosine N-methyltransferase, GSDMT, Gsm, GsmA, GSMT, GSMT2, MXAN 7068, more
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine
show the reaction diagram
S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine
show the reaction diagram