Reference on EC 2.1.1.13 - methionine synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kolhouse, J.F.; Allen, R.H.
Recognition of two intracellular cobalamin binding proteins and their identification as methylmalonyl-CoA mutase and methionine synthetase
Proc. Natl. Acad. Sci. USA
74
921-925
1977
Oryctolagus cuniculus
Buchanan, J.M.
Methionine biosynthesis (hog liver)
Methods Enzymol.
17B
371-378
1971
Sus scrofa
-
Cheng, F.W.; Shane, B.; Stokstad, E.L.R.
Pentaglutamate derivatives of folate as substrates for rat liver tetrahydropteroylglutamate methyltransferase and 5,10-methylenetetrahydrofolate reductase
Can. J. Biochem.
53
1020-1027
1975
Rattus norvegicus
-
Guest, J.R.; Friedman, S.; Foster, M.A.; Tejerina, G.; Woods, D.D.
Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli
Biochem. J.
92
497-504
1964
Escherichia coli, Escherichia coli B / ATCC 11303
Loughlin, R.E.; Elford, H.L.; Buchanan, J.M.
Enzymatic synthesis of the methyl group of methionine
J. Biol. Chem.
239
2888-2895
1964
Sus scrofa
Foster, M.A.; Dilworth, M.J.; Woods, D.D.
Cobalamin and the synthesis of methionine by Escherichia coli
Nature
201
39-42
1964
Escherichia coli
Gonzalez, J.C.; Banerjee, R.V.; Huang, S.; Sumner, J.S.; Matthews, R.G.
Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem
Biochemistry
31
6045-6056
1992
Escherichia coli
Luschinsky, C.L.; Drummond, J.T.; Matthews, R.G.; Ludwig, M.L.
Crystallization and preliminary X-ray diffraction studies of the cobalamin-binding domain of methionine synthase from Escherichia coli
J. Mol. Biol.
225
557-560
1992
Escherichia coli
Magnum, J.H.; Steuart, B.W.; North, J.A.
The isolation of N5-methyltetrahydrofolate-homocysteine transmethylase from bovine brain
Arch. Biochem. Biophys.
148
63-69
1972
Bos taurus
Taylor, R.T.; Hanna, M.L.
Escherichia coli B N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: binding of the folate substrate to the enzyme
Arch. Biochem. Biophys.
151
401-413
1972
Escherichia coli, Escherichia coli B / ATCC 11303
Rudiger, H.
On the cation sensibility of the vitamin B12-dependent methionine synthetase (5-methyltetrahydrofolate-homocysteine-methyltransferase from Escherichia coli)
FEBS Lett.
35
295-298
1973
Escherichia coli
Mangum, J.H.; North, J.A.
Isolation of a cobalamin containing 5-methyltetrahydrofolate-homocysteine transmethylase from mammalian kidney
Biochemistry
10
3765-3769
1971
Sus scrofa
Taylor, R.T.
Escherichia coli B N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: gel-filtration behavior of apoenzyme and holoenzymes
Biochim. Biophys. Acta
242
355-364
1971
Escherichia coli, Escherichia coli B / ATCC 11303
Frasca, V.; Banerjee, R.V.; Dunham, W.R.; Sands, R.; Matthews, R.G.
Cobalamin-dependent methionine synthase from Escherichia coli B: Electron paramagnetic resonance spectra of the inactive form and the active methylated form of the enzyme
Biochemistry
27
8458-8465
1988
Escherichia coli
Taylor, R.T.; Weissbach, H.
N5-Methyltetrahydrofolate-homocysteine methyltransferases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
12
121-165
1973
Klebsiella aerogenes, Bos taurus, Gallus gallus, Auxenochlorella pyrenoidosa, Escherichia coli, Homo sapiens, Ochromonas malhamensis, Rattus norvegicus, Cereibacter sphaeroides, Salmonella enterica subsp. enterica serovar Typhimurium, Sus scrofa
-
Sato, K.; Hiei, E.; Shimizu, S.
Affinity chromatography of N5-methyltetrahydrofolate-homocysteine methyltransferase on a cobalamin-Sepharose
FEBS Lett.
85
73-76
1978
Escherichia coli
Grabau, W.; Rudiger, H.
Purification and properties of the tetrahydropteroylglutamate methyltransferase from green beans (Phaseolus vulgaris)
Hoppe-Seyler's Z. Physiol. Chem.
358
695-698
1977
Phaseolus vulgaris
Kageyama, M.; Perlman, D.
Inhibition of N5-methyltetrahodrofolate-homocysteine transmethylase by a vitamin B12-antimetabolite
Biochem. Biophys. Res. Commun.
76
420-423
1977
Escherichia coli, Escherichia coli B / ATCC 11303
Taylor, R.T.; Weissbach, H.
N5-Methytetrahydrofolate-homocysteine (vitamin B12) methyltransferase (Escherichia coli B)
Methods Enzymol.
17B
379-388
1971
Escherichia coli, Escherichia coli B / ATCC 11303
-
Lucchini, G.; Piazza, I.; Biachetti, R.
B12-dependent methyl-H4-Folate homocysteine methyltransferase in Euglena gracilis
Plant Sci. Lett.
36
177-179
1984
Euglena gracilis
-
Sauer, H.
Methionine synthase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
3
304-311
1983
Escherichia coli, Homo sapiens
-
Ohmori, H.; Fukui, S.
Vitamin B12-dependent methionine synthetase in photosynthetic bacteria: Partial purification and properties
Agric. Biol. Chem.
38
1317-1324
1974
Chromatium sp., Rhodospirillum rubrum, Chromatium sp. D
-
Fujii, K.; Huennekens, F.M.
Activation of methionine synthetase by a reduced triphosphopyridine nucleotide-dependent flavoprotein system
J. Biol. Chem.
249
6745-6753
1974
Escherichia coli
Coward, J.K.; Chello, P.L.; Cashmore, A.R.; Parameswaran, K.N.; DeAngelis, L.M.; Bertiono, J.R.
5-methyl-5,6,7,8-tetrahydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with methionine synthetase from bovine brain
Biochemistry
14
1548-1552
1975
Bos taurus
Kolhouse, J.F.; Utley, C.; Stabler, S.P.; Allen, R.H.
Mechanism of conversion of human apo- to holomethionine synthase by various forms of cobalamin
J. Biol. Chem.
266
23010-23015
1991
Escherichia coli, Homo sapiens, Rattus norvegicus, Escherichia coli B / ATCC 11303
Beck, W.S.; Thorndike, J.
Differences in coenzyme specificity of the N5-methyltetrahydrofolate-homocysteine methyltransferases of various species: implications for corrin binding loci
Biochem. Biophys. Res. Commun.
120
74-80
1984
Escherichia coli, Homo sapiens, Propionibacterium freudenreichii subsp. shermanii, Rattus norvegicus
Utley, C.S.; Marcell, P.D.; Allen, R.H.; Antony, A.C.; Kolhouse, J.F.
Isolation and characterization of methionine synthetase from human placenta
J. Biol. Chem.
260
13656-13665
1985
Homo sapiens
Paessens, A.; Rudiger, H.
Purification and chemical characterization of the vitamin-B12-dependent 5-methyltetrahydrofolate: homocysteine methyltransferase from Escherichia coli B
Eur. J. Biochem.
112
47-51
1980
Escherichia coli, Homo sapiens, Escherichia coli B / ATCC 11303
Matthews, R.G.
Cobalamin-dependent methyltransferases
Acc. Chem. Res.
34
681-689
2001
Escherichia coli
Yamada, K.; Kawata, T.; Wada, M.; Isshiki, T.; Onoda, J.; Kawanishi, T.; Kunou, A.; Tadokoro, T.; Tobimatsu, T.; Maekawa, A.; Toraya, T.
Extremely low activity of methionine synthase in vitamin B-12-deficient rats may be related to effects on coenzyme stabilization rather than to changes in coenzyme induction
J. Nutr.
130
1894-1900
2000
Rattus norvegicus
Jarrett, J.T.; Goulding, C.W.; Fluhr, K.; Huang, S.; Matthews, R.G.
Purification and assay of cobalamin-dependent methionine synthase from Escherichia coli
Methods Enzymol.
281
196-213
1997
Escherichia coli
Chen, Z.; Crippen, K.; Gulati, S.; Banerjee, R.
Purification and kinetic mechanism of a mammalian methionine synthase from pig liver
J. Biol. Chem.
269
27193-27197
1994
Sus scrofa
Bandarian, V.; Matthews, R.G.
Quantitation of rate enhancements attained by the binding of cobalamin to methionine synthase
Biochemistry
40
5056-5064
2001
Escherichia coli
Hall, D.A.; Jordan-Starck, T.C.; Loo, R.O.; Ludwig, M.L.; Matthews, R.G.
Interaction of flavodoxin with cobalamin-dependent methionine synthase
Biochemistry
39
10711-10719
2000
Escherichia coli (P13009), Escherichia coli
Hall, D.A.; Vander Kooi, C.W.; Stasik, C.N.; Stevens, S.Y.; Zuiderweg, E.R.P.; Matthews, R.G.
Mapping the interactions between flavodoxin and its physiological partners flavodoxin reductase and cobalamin-dependent methionine synthase
Proc. Natl. Acad. Sci. USA
98
9521-9526
2001
Escherichia coli
Kenyon, S.H.; Nicolaou, A.; Ast, T.; Gibbons, W.A.
Stimulation in vitro of vitamin B12-dependent methionine synthase by polyamines
Biochem. J.
316
661-665
1996
Rattus norvegicus
-
Jarrett, J.T.; Huang, S.; Matthews, R.G.
Methionine synthase exists in two distinct conformations that differ in reactivity toward methyltetrahydrofolate, adenosylmethionine, and flavodoxin
Biochemistry
37
5372-5382
1998
Escherichia coli
Goulding, C.W.; Matthews, R.G.
Cobalamin-dependent methionine synthase from Escherichia coli: Involvement of zinc in homocysteine activation
Biochemistry
36
15749-15757
1997
Escherichia coli
Yamada, K.; Yamada, S.; Tobimatsu, T.; Torava, T.
Heterologous high level expression, purification, and enzymological properties of recombinant rat cobalamin-dependent methionine synthase
J. Biol. Chem.
274
35571-35576
1999
Rattus norvegicus
Goulding, C.W.; Postigo, D.; Matthews, R.G.
Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine
Biochemistry
36
8082-8091
1997
Escherichia coli (P13009)
Gulati, S.; Brody, L.C.; Banerjee, R.
Posttranscriptional regulation of mammalian methionine synthase by B12
Biochem. Biophys. Res. Commun.
259
436-442
1999
Chlorocebus aethiops, Homo sapiens
Drummond, J.T.; Matthews, R.G.
Nitrous oxide degradation by cobalamin-dependent methionine synthase: characterization of the reactants and products in the inactivation reaction
Biochemistry
33
3732-3741
1994
Escherichia coli
Kenyon, S.H.; Waterfield, C.J.; Timbrell, J.A.; Nicolaou, A.
Methionine synthase activity and sulphur amino acid levels in the rat liver tumour cells HTC and Phi-1
Biochem. Pharmacol.
63
381-391
2002
Rattus norvegicus
Huang, L.; Zhang, J.; Hayakawa, T.; Tsuge, H.
Assays of methylenetetrahydrofolate reductase and methionine synthase activities by monitoring 5-methyltetrahydrofolate and tetrahydrofolate using high-performance liquid chromatography with fluorescence detection
Anal. Biochem.
299
253-259
2001
Bos taurus, Gallus gallus, Myzopsetta ferruginea, Scombridae, Rattus norvegicus, Sus scrofa
Isegawa, Y.; Watanabe, F.; Kitaoka, S.; Nakano, Y.
Subcellular distribution of cobalamin-dependent methionine synthase in Euglena gracilis Z
Phytochemistry
35
59-61
1994
Euglena gracilis
-
Zhou, Z.S.; Smith, A.E.; Matthews, R.G.
L-Selenohomocysteine: One-step synthesis from L-selenomethionine and kinetic analysis as substrate for methionine synthases
Bioorg. Med. Chem. Lett.
10
2471-2475
2000
Escherichia coli
Peariso, K.; Zhou, Z.S.; Smith, A.E.; Matthews, R.G.; Penner-Hahn, J.E.
characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy
Biochemistry
40
987-993
2001
Escherichia coli
Bannerjee, R.V.; Harder, S.R.; Ragsdale, S.W.; Matthews, R.G.
Mechanism of reductive activation of cobalamin-dependent methionine synthase: An electron paramagnetic resonance spectroelectrochemical study
Biochemistry
29
1129-1135
1990
Escherichia coli
Kacprzak, M.M.; Lewandowska, I.; Matthews, R.G.; Paszewski, A.
Transcriptional regulation of methionine synthase by homocysteine and choline in Aspergillus nidulans
Biochem. J.
376
517-524
2003
Aspergillus nidulans
Ortiou, S.; Alberto, J.M.; Gueant, J.L.; Merten, M.
Homocysteine increases methionine synthase mRNA level in Caco-2 cells
Cell. Physiol. Biochem.
14
407-414
2004
Homo sapiens
Bandarian, V.; Pattridge, K.A.; Lennon, B.W.; Huddler, D.P.; Matthews, R.G.; Ludwig, M.L.
Domain alteration switches B12-dependent methionine synthase to the activation conformation
Nat. Struct. Biol.
9
53-56
2002
Escherichia coli (P13009), Escherichia coli
Narita, Y.; Taguchi, H.; Nakamura, T.; Ueda, A.; Shi, W.; Takabe, T.
Characterization of the salt-inducible methionine synthase from barley leaves
Plant Sci.
167
1009-1016
2004
Hordeum vulgare
Evans, J.C.; Huddler, D.P.; Hilgers, M.T.; Romanchuk, G.; Matthews, R.G.; Ludwig, M.L.
Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase
Proc. Natl. Acad. Sci. USA
101
3729-3736
2004
Thermotoga maritima
Sarbia, M.; Stahl, M.; von Weyhern, C.; Weirich, G.; Puehringer-Oppermann, F.
The prognostic significance of genetic polymorphisms (methylenetetrahydrofolate reductase C677T, methionine synthase A2756G, thymidilate synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma
Br. J. Cancer
94
203-207
2006
Homo sapiens
Banks, E.C.; Doughty, S.W.; Toms, S.M.; Wheelhouse, R.T.; Nicolaou, A.
Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles
FEBS J.
274
287-299
2007
Rattus norvegicus
Wolthers, K.R.; Toogood, H.S.; Jowitt, T.A.; Marshall, K.R.; Leys, D.; Scrutton, N.S.
Crystal structure and solution characterization of the activation domain of human methionine synthase
FEBS J.
274
738-750
2007
Homo sapiens
Oltean, S.; Banerjee, R.
A B12-responsive internal ribosome entry site (IRES) element in human methionine synthase
J. Biol. Chem.
280
32662-32668
2005
Homo sapiens
Yamada, K.; Gravel, R.A.; Toraya, T.; Matthews, R.G.
Human methionine synthase reductase is a molecular chaperone for human methionine synthase
Proc. Natl. Acad. Sci. USA
103
9476-9481
2006
Homo sapiens
Tang, C.; Zhang, Z.; Xu, B.; Li, M.; Liu, J.; Cui, J.
Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro
Anticancer Drugs
19
697-704
2008
Homo sapiens
Roeder, S.; Dreschler, K.; Wirtz, M.; Cristescu, S.M.; van Harren, F.J.; Hell, R.; Piechulla, B.
SAM levels, gene expression of SAM synthetase, methionine synthase and ACC oxidase, and ethylene emission from N. suaveolens flowers
Plant Mol. Biol.
70
535-546
2009
Nicotiana suaveolens
Prasannan, P.; Suliman, H.S.; Robertus, J.D.
Kinetic analysis of site-directed mutants of methionine synthase from Candida albicans
Biochem. Biophys. Res. Commun.
382
730-734
2009
Candida albicans
Naushad, S.; Jain Jamal, M.; Prasad, C.; Rama Devi, A.
Relationship between methionine synthase, methionine synthase reductase genetic polymorphisms and deep vein thrombosis among South Indians
Clin. Chem. Lab. Med.
46
73-79
2008
Homo sapiens
Bera, S.; Wallimann, T.; Ray, S.; Ray, M.
Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells
FEBS J.
275
5899-5909
2008
Mus musculus
Wolthers, K.R.; Scrutton, N.S.
Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex
FEBS J.
276
1942-1951
2009
Homo sapiens
Liptak, M.D.; Datta, S.; Matthews, R.G.; Brunold, T.C.
Spectroscopic study of the cobalamin-dependent methionine synthase in the activation conformation: effects of the Y1139 residue and S-adenosylmethionine on the B12 cofactor
J. Am. Chem. Soc.
130
16374-16381
2008
Escherichia coli
Brosnan, J.T.; Wijekoon, E.P.; Warford-Woolgar, L.; Trottier, N.L.; Brosnan, M.E.; Brunton, J.A.; Bertolo, R.F.
Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance
J. Nutr.
139
1292-1297
2009
Sus scrofa
Koutmos, M.; Pejchal, R.; Bomer, T.M.; Matthews, R.G.; Smith, J.L.; Ludwig, M.L.
Metal active site elasticity linked to activation of homocysteine in methionine synthases
Proc. Natl. Acad. Sci. USA
105
3286-3291
2008
Thermotoga maritima
Datta, S.; Koutmos, M.; Pattridge, K.A.; Ludwig, M.L.; Matthews, R.G.
A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor
Proc. Natl. Acad. Sci. USA
105
4115-4120
2008
Escherichia coli (P13009), Escherichia coli
Koutmos, M.; Datta, S.; Pattridge, K.A.; Smith, J.L.; Matthews, R.G.
Insights into the reactivation of cobalamin-dependent methionine synthase
Proc. Natl. Acad. Sci. USA
106
18527-18532
2009
Escherichia coli (P13009)
Wang, Y.C.; Chen, Y.M.; Lin, Y.J.; Liu, S.P.; Chiang, E.P.
GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation
Mol. Med.
17
486-494
2011
Mus musculus
Elshihawy, H.; Helal, M.A.; Said, M.; Hammad, M.A.
Design, synthesis, and enzyme kinetics of novel benzimidazole and quinoxaline derivatives as methionine synthase inhibitors
Bioorg. Med. Chem.
22
550-558
2014
Rattus norvegicus (Q9Z2Q4)
Hayashi, T.; Morita, Y.; Mizohata, E.; Oohora, K.; Ohbayashi, J.; Inoue, T.; Hisaeda, Y.
Co(II)/Co(I) reduction-induced axial histidine-flipping in myoglobin reconstituted with a cobalt tetradehydrocorrin as a methionine synthase model
Chem. Commun. (Camb. )
50
12560-12563
2014
synthetic construct
Deng, X.; Guo, Y.; Tian, C.; Liu, J.; Wang, X.; Zhang, Z.
Design, synthesis and activities of aziridine derivatives of N5-methyltetrahydrofolate against methionine synthase
Chem. Res. Chin. Univ.
31
742-745
2015
Homo sapiens
-
Fofou-Caillierez, M.B.; Mrabet, N.T.; Chery, C.; Dreumont, N.; Flayac, J.; Pupavac, M.; Paoli, J.; Alberto, J.M.; Coelho, D.; Camadro, J.M.; Feillet, F.; Watkins, D.; Fowler, B.; Rosenblatt, D.S.; Gueant, J.L.
Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia
Hum. Mol. Genet.
22
4591-4601
2013
Homo sapiens
Kozlowski, P.M.; Kamachi, T.; Kumar, M.; Yoshizawa, K.
Reductive elimination pathway for homocysteine to methionine conversion in cobalamin-dependent methionine synthase
J. Biol. Inorg. Chem.
17
611-619
2012
Escherichia coli (P13009)
Kumar, N.; Kozlowski, P.M.
Mechanistic insights for formation of an organometallic Co-C bond in the methyl transfer reaction catalyzed by methionine synthase
J. Phys. Chem. B
117
16044-16057
2013
Thermotoga maritima (Q9WYA5), Thermotoga maritima ATCC 43589 (Q9WYA5)
Bassila, C.; Ghemrawi, R.; Flayac, J.; Froese, D.S.; Baumgartner, M.R.; Gueant, J.L.; Coelho, D.
Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC
Biochim. Biophys. Acta
1863
103-112
2017
Homo sapiens (Q99707)
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