Information on EC 2.1.1.121 - 6-O-methylnorlaudanosoline 5'-O-methyltransferase

for references in articles please use BRENDA:EC2.1.1.121
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The expected taxonomic range for this enzyme is: Argemone platyceras

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EC NUMBER
COMMENTARY hide
2.1.1.121
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RECOMMENDED NAME
GeneOntology No.
6-O-methylnorlaudanosoline 5'-O-methyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
papaverine biosynthesis
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Isoquinoline alkaloid biosynthesis
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-
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase
Nororientaline is a precursor of the alkaloid papaverine.
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CAS REGISTRY NUMBER
COMMENTARY hide
89511-99-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
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Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-Adenosyl-L-methionine + 6-O-methylnorlaudanosoline
?
show the reaction diagram
-
the product nororientaline is a precursor of the alkaloid papaverine
-
-
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S-Adenosyl-L-methionine + 6-O-methylnorlaudanosoline
S-Adenosyl-L-homocysteine + nororientaline
show the reaction diagram
-
-
-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-Adenosyl-L-methionine + 6-O-methylnorlaudanosoline
?
show the reaction diagram
-
the product nororientaline is a precursor of the alkaloid papaverine
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-
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Fe3+
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5 mM, complete inhibition
Hg2+
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5 mM, complete inhibition
Iodobenzoate
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10 mM, 79% inhibition
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NEM
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5 mM, 82% inhibition
PCMB
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5 mM, 84% inhibition
S-adenosyl-L-homocysteine
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-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.4
6-O-methylnorlaudanosoline
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-
0.05
S-adenosyl-L-methionine
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-
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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-
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
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half-life: 33 h
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
complete inactivation by freezing even in presence of 30% glycerol
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4�C, 0.05% NaN3, stable for 4 weeks
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 2.1.1.121)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)