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IUBMB CommentsNororientaline is a precursor of the alkaloid papaverine.
The expected taxonomic range for this enzyme is: Argemone platyceras
Synonyms
(6-O-Methylnorlaudanosoline)-5'-O-methyltransferase, Methyltransferase, 6-methylnorlaudanosoline 5'-,
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(6-O-Methylnorlaudanosoline)-5'-O-methyltransferase
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Methyltransferase, 6-methylnorlaudanosoline 5'-
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S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline
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methyl group transfer
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S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase
Nororientaline is a precursor of the alkaloid papaverine.
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S-Adenosyl-L-methionine + 6-O-methylnorlaudanosoline
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the product nororientaline is a precursor of the alkaloid papaverine
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S-Adenosyl-L-methionine + 6-O-methylnorlaudanosoline
S-Adenosyl-L-homocysteine + nororientaline
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S-Adenosyl-L-methionine + 6-O-methylnorlaudanosoline
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the product nororientaline is a precursor of the alkaloid papaverine
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Fe3+
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5 mM, complete inhibition
Hg2+
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5 mM, complete inhibition
iodobenzoate
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10 mM, 79% inhibition
NEM
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5 mM, 82% inhibition
PCMB
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5 mM, 84% inhibition
S-adenosyl-L-homocysteine
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0.4
6-O-methylnorlaudanosoline
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0.05
S-adenosyl-L-methionine
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additional information
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complete inactivation by freezing even in presence of 30% glycerol
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4°C, 0.05% NaN3, stable for 4 weeks
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Rueffer, M.; Nagakura, N.; Zenk, M.H.
A highly specific O-methyltransferase for nororientaline synthesis isolated from Argemone platyceras cell cultures
Planta Med.
49
196-198
1983
Argemone platyceras
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2.1.1.121 6-O-methylnorlaudanosoline 5'-O-methyltransferase
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