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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms methionine methyltransferase, s-adenosyl-l-methionine methyltransferase, yil064p, methionine s-methyltransferase, see1p, s-adenosyl-l-methionine:l-methionine s-methyltransferase, more
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methionine methyltransferase
methyltransferase, methionine S-
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S-adenosyl methionine:methionine methyl transferase
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S-adenosyl-L-methionine methyltransferase
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recognized by sequence similarity as a putative S-adenosyl-L-methionine methyltransferase
S-adenosylmethionine transmethylase
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S-adenosylmethionine-methionine methyltransferase
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See1p
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secretion and early endocytosis 1 protein
methionine methyltransferase
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methionine methyltransferase
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MMT
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S-adenosyl-L-methionine + L-methionine + H+ = S-adenosyl-L-homocysteine + S-methyl-L-methionine
S-adenosyl-L-methionine + L-methionine + H+ = S-adenosyl-L-homocysteine + S-methyl-L-methionine
ordered bi bi mechanism with S-adenosylmethionine the first reactant to bind and S-adenosylhomocysteine the last product to be released
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S-adenosyl-L-methionine + L-methionine + H+ = S-adenosyl-L-homocysteine + S-methyl-L-methionine
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methyl group transfer
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methyl group transfer
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MetaCyc
dimethylsulfoniopropanoate biosynthesis I (Wollastonia), dimethylsulfoniopropanoate biosynthesis II (Spartina), S-methyl-L-methionine cycle, seleno-amino acid detoxification and volatilization I, seleno-amino acid detoxification and volatilization II
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S-adenosyl-L-methionine:L-methionine S-methyltransferase
Requires Zn2+ or Mn2+
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: enzyme is involved in S-methylmethionine cycle Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
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Substrates: key enzyme in volatilization of selenium Products: -
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S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
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Substrates: key enzyme in volatilization of selenium Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: - Products: -
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S-adenosyl-L-methionine + L-methionine
S-adenosyl-L-homocysteine + S-methyl-L-methionine
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Substrates: enzyme is involved in S-methylmethionine cycle Products: -
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S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
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Substrates: key enzyme in volatilization of selenium Products: -
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S-adenosyl-L-methionine + selenomethionine
S-adenosyl-L-homocysteine + selenium-methyl-L-seleniummethionine
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Substrates: key enzyme in volatilization of selenium Products: -
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Zn2+
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enzyme requires 0.1 mM Zn2+ or 1 mM Mn2+
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3-(methylthio)propanol
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3-(methylthio)propionate
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3-(methylthio)propionate methyl ester
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3-(methylthio)propylamine
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3-dimethylsulfoniopropionaldehyde
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DL-2-hydroxy-4-(methylthio)butyrate
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N-2,4-dinitrophenyl-DL-Met
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NEM
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0.5 mM, 99% inhibition
p-hydroxymercuribenzoate
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0.1 mM; 97% inhibition
S-adenosyl-L-homocysteine
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S-methyl-L-methionine
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0.034
S-adenosyl-L-methionine
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0.013
S-adenosyl-L-homocysteine
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0.226
S-methyl-L-methionine
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additional information
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quick, simple, and specific method for measuring enzyme activity
additional information
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5.7 - 7.3
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about 60% of activity maximum at pH 5.7 and pH 7.3
5.8 - 9
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about 50-55% of optimal activity at pH 5.8 and 9.0, only 1% of optimal activity at pH 5.0
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activity does not change significantly during the first 2 d of germination, increases during the 3rd and 4th day
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additional information
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no activity in the root or endosperm
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predicted
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Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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physiological function
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the first in vivo data identify Yil064p as a novel component of intracellular transport, methyltransferase activity is predicted
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115000
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x * 115000, SDS-PAGE
115000
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4 * 115000, SDS-PAGE
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tetramer
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4 * 115000, SDS-PAGE
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25
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complete inactivation after 24 h
4
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complete inactivation after 1 week
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-20 C, complete inactivation after flash freezing in liquid N2
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expressed in Escherichia coli
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expression in Escherichia coli
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Karr, D.; Tweto, J.; Albersheim, P.
S-Adenosyl methionine: methionine methyl transferase from wheat germ
Arch. Biochem. Biophys.
121
732-738
1967
Triticum aestivum
brenda
Mudd, S.H.; Datko, A.H.
The S-methylmethionine cycle in Lemna paucicostata
Plant Physiol.
93
623-630
1990
Daucus carota, Glycine max, Lemna aequinoctialis
brenda
James, F.; Nolte, K.D.; Hanson, A.D.
Purification and properties of S-adenosyl-L-methionine:L-methionine S-methyltransferase from Wollastonia biflora leaves
J. Biol. Chem.
270
22344-22350
1995
Brassica oleracea, Lactuca sativa, Trifolium repens, Wollastonia biflora, Zea mays
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Pimenta, M.J.; Kaneta, T.; Larondelle, Y.; Dohmae, N.; Kamiya, Y.
S-Adenosyl-L-methionine:L-methionine S-methyltransferase from germinating barley. Purification and localization
Plant Physiol.
118
431-438
1998
Hordeum vulgare
brenda
Tagmount, A.; Berken, A.; Terry, N.
An essential role of S-adenosyl-L-methionine:L-methionine S-methyltransferase in selenium volatilization by plants. Methylation of selenomethionine to selenium-methyl-L-selenium-methionine, the precursor of volatile selenium
Plant Physiol.
130
847-856
2002
Arabidopsis sp., Brassica juncea
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Pimenta, M.J.; Vandercammen, A.V.; Dufour, J.P.; Larondelle, Y.
Determination of S-adenosyl-L-methionine:L-methionine S-methyltransferase activity by selective adsorption of [methyl-3H]S-adenosylmethionine onto activated charcoal
Anal. Biochem.
225
167-169
1995
Hordeum vulgare
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Mueller, I.; Weinig, S.; Steinmetz, H.; Kunze, B.; Veluthoor, S.; Mahmud, T.; Mueller, R.
A unique mechanism for methyl ester formation via an amide intermediate found in myxobacteria
ChemBioChem
7
1197-1205
2006
Stigmatella aurantiaca
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Lee, M.; Huang, T.; Toro-Ramos, T.; Fraga, M.; Last, R.L.; Jander, G.
Reduced activity of Arabidopsis thaliana HMT2, a methionine biosynthetic enzyme, increases seed methionine content
Plant J.
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310-320
2008
Arabidopsis thaliana
brenda
Martin-Granados, C.; Riechers, S.P.; Stahl, U.; Lang, C.
Absence of See1p, a widely conserved Saccharomyces cerevisiae protein, confers both deficient heterologous protein production and endocytosis
Yeast
25
871-877
2008
Saccharomyces cerevisiae
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