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IUBMB CommentsDihydrosterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.
The enzyme appears in viruses and cellular organisms
Synonyms
o-methyltransferase ii,
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methyltransferase, sterigmatocystin
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O-methyltransferase II
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sterigmatocystin methyltransferase
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S-adenosyl-L-methionine + dihydrosterigmatocystin = S-adenosyl-L-homocysteine + 8-O-methyldihydrosterigmatocystin
(2)
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S-adenosyl-L-methionine + sterigmatocystin = S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
(1)
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methyl group transfer
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S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase
Dihydrosterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.
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S-adenosyl-L-methionine + dihydrosterigmatocystin
S-adenosyl-L-homocysteine + dihydro-8-O-methylsterigmatocystin
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
S-adenosyl-L-methionine + dihydrosterigmatocystin
S-adenosyl-L-homocysteine + dihydro-8-O-methylsterigmatocystin
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S-adenosyl-L-methionine + dihydrosterigmatocystin
S-adenosyl-L-homocysteine + dihydro-8-O-methylsterigmatocystin
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S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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penultimate step in aflatoxin biosynthetic pathway
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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involved in the biosynthesis of aflatoxins in fungi
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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involved in the biosynthesis of aflatoxins in fungi
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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penultimate step in aflatoxin biosynthetic pathway
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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involved in the biosynthesis of aflatoxins in fungi
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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penultimate step in aflatoxin biosynthetic pathway
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?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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penultimate step in aflatoxin biosynthetic pathway
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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involved in the biosynthesis of aflatoxins in fungi
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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involved in the biosynthesis of aflatoxins in fungi
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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penultimate step in aflatoxin biosynthetic pathway
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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involved in the biosynthesis of aflatoxins in fungi
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?
S-adenosyl-L-methionine + sterigmatocystin
S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin
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penultimate step in aflatoxin biosynthetic pathway
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?
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Cu2+
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0.1 mM, 58% inhibition
Fe2+
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0.1 mM, 87% inhibition
Hg2+
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0.1 mM, complete inhibition
Phenylmercuriacetate
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0.1 mM, 96% inhibition
S-adenosyl-L-homocysteine
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0.0096 - 0.042
S-adenosyl-L-methionine
0.0018 - 0.002
sterigmatocystin
0.0096
S-adenosyl-L-methionine
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0.042
S-adenosyl-L-methionine
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0.0018
sterigmatocystin
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0.002
sterigmatocystin
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0.022 - 2.2
sterigmatocystin
0.022
sterigmatocystin
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0.0012
S-adenosyl-L-homocysteine
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25 - 60
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approx. 35% of maximal activity at 25°C, approx. 30% of maximal activity at 60°C
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brenda
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brenda
NIAH-26
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brenda
SRCC 163
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brenda
CP461, SRCC 2043
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brenda
NIAH-26
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brenda
SRCC 163
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brenda
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brenda
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brenda
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brenda
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OMTA_ASPFN
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)
418
0
46776
Swiss-Prot
other Location (Reliability: 3)
AFLP_ASPPU
Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
418
0
46397
Swiss-Prot
other Location (Reliability: 3)
A0A221SE35_ASPFL
78
0
8669
TrEMBL
other Location (Reliability: 1)
C5PDX4_COCP7
Coccidioides posadasii (strain C735)
521
0
57824
TrEMBL
other Location (Reliability: 5)
A2R682_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
386
0
43707
TrEMBL
other Location (Reliability: 2)
A0A221SE34_ASPFL
78
0
8705
TrEMBL
other Location (Reliability: 1)
A2QYX1_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
398
0
44111
TrEMBL
other Location (Reliability: 2)
A0A221SE32_ASPFL
78
0
8600
TrEMBL
other Location (Reliability: 1)
A2QH40_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
429
0
48218
TrEMBL
other Location (Reliability: 5)
A2QH35_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
443
0
48648
TrEMBL
other Location (Reliability: 5)
A2QNG2_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
380
0
42870
TrEMBL
other Location (Reliability: 2)
A0A2K9LB52_ASPFL
63
0
6980
TrEMBL
other Location (Reliability: 2)
A2R233_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
447
0
49702
TrEMBL
other Location (Reliability: 1)
A0A2K9L8I8_ASPFL
63
0
7007
TrEMBL
other Location (Reliability: 2)
A2QZL7_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
448
0
50463
TrEMBL
other Location (Reliability: 1)
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110000
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1 * 110000 + 1 * 58000, SRCC 163, SDS-PAGE
40000
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x * 40000, SRRC 163, SDS-PAGE, the 40000 Da protein is distinct from the 168000 Da methyl transferase purified from the same fungal strain
58000
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1 * 110000 + 1 * 58000, SRCC 163, SDS-PAGE
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?
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x * 40000, SRRC 163, SDS-PAGE, the 40000 Da protein is distinct from the 168000 Da methyl transferase purified from the same fungal strain
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x * 40000, SRRC 163, SDS-PAGE, the 40000 Da protein is distinct from the 168000 Da methyl transferase purified from the same fungal strain
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dimer
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1 * 110000 + 1 * 58000, SRCC 163, SDS-PAGE
dimer
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1 * 110000 + 1 * 58000, SRCC 163, SDS-PAGE
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strain SRRC 163, anion exchange, hydroxylapatite, DEAE-Sperodex, octyl avidgel, anion-exchange
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strain SRRC 2043, ultracentrifugation, ammonium sulfate, DEAE-Sephadex, immunoaffinity column
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Yabe, K.; Ando, Y.; Hashimoto, J.; Hamasaki, T.
Two distinct O-methyltransferases in aflatoxin biosynthesis
Appl. Environ. Microbiol.
55
2172-2177
1989
Aspergillus parasiticus, Aspergillus parasiticus NIAH-26
brenda
Bhatnagar, D.; Ullah, A.H.J.; Cleveland, T.E.
Purification and characterization of a methyltransferase from Aspergillus parasiticus SRRC 163 involved in aflatoxin biosynthetic pathway
Prep. Biochem.
18
321-349
1988
Aspergillus parasiticus, Aspergillus parasiticus SRCC 163
brenda
Bhatnagar, D.; McCormick, S.P.; Lee, L.S.; Hill, R.A.
Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus
Appl. Environ. Microbiol.
53
1028-1033
1987
Aspergillus parasiticus
brenda
Keller, N.P.; Dischinger, H.C.; Bhatnagar, D.; Cleveland, T.E.; Ullah, A.H.J.
Purification of a 40-kilodalton methyltransferase active in the aflatoxin biosynthetic pathway
Appl. Environ. Microbiol.
59
479-484
1993
Aspergillus flavus, Aspergillus parasiticus, Aspergillus parasiticus SRCC 163
brenda
Liu, B.H.; Bhatnagar, D.; Chu, F.S.
Purification and characterization of 40-kDa sterigmatocystin O-methyltransferase involved in aflatoxin biosynthesis
Nat. Toxins
7
63-69
1999
Aspergillus flavus, Aspergillus parasiticus, Aspergillus flavus 3357
brenda
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2.1.1.110 sterigmatocystin 8-O-methyltransferase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
