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Information on EC - uroporphyrinogen-III C-methyltransferase

for references in articles please use BRENDA:EC2.1.1.107

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IUBMB Comments

This enzyme catalyses two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2. It is the first of three steps leading to the formation of siroheme from uroporphyrinogen III. The second step involves an NAD+-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC, precorrin-2 dehydrogenase) and the third step involves the chelation of Fe2+ to sirohydrochlorin to form siroheme (EC, sirohydrochlorin ferrochelatase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirA being responsible for the above reaction. Also involved in the biosynthesis of cobalamin.

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
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uroporphyrinogen iii methyltransferase, s-adenosyl-l-methionine:uroporphyrinogen iii methyltransferase, uroporphyrinogen iii methylase, s-adenosyl-l-methionine uroporphyrinogen iii methyltransferase, sam-dependent uroporphyrinogen iii methyltransferase, uroporphyrinogen-iii c-methyltransferase, sirohaem synthase, uroporphyrinogen iii synthase/methyltransferase, s-adenosyl-l-methionine-dependent uroporphyrinogen iii methyltransferase, uroporphyrinogen iii c-methyltransferase, more

2 S-adenosyl-L-methionine + uroporphyrinogen III = 2 S-adenosyl-L-homocysteine + precorrin-2
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overall reaction
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2
show the reaction diagram
S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1
show the reaction diagram
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