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Information on EC 2.1.1.102 - demethylmacrocin O-methyltransferase

for references in articles please use BRENDA:EC2.1.1.102

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IUBMB Comments

Requires Mg2+. The enzyme, isolated from the bacterium Streptomyces fradiae, is involved in the biosynthesis of the macrolide antibiotic tylosin. The 2-hydroxy group of a 6-deoxy-D-allose moiety in demethylmacrocin acts as the methyl acceptor. Also acts on demethyllactenocin, giving lactenocin. Not identical with EC 2.1.1.101 macrocin O-methyltransferase.

The enzyme appears in viruses and cellular organisms

Synonyms
demethylmacrocin o-methyltransferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin
show the reaction diagram
the 2-hydroxyl group of a 6-deoxy-D-allose residue in demethylmacrocin acts as a methyl acceptor. Not identical with EC 2.1.101 macrocin O-methyltransferase
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PATHWAY SOURCE
PATHWAYS
MetaCyc
tylosin biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links