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Information on EC 2.1.1.100 - protein-S-isoprenylcysteine O-methyltransferase and Organism(s) Arabidopsis thaliana and UniProt Accession Q93W54

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IUBMB Comments
C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, but more slowly.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q93W54
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
ste14p, isoprenylcysteine carboxyl methyltransferase, isoprenylcysteine carboxylmethyltransferase, prenylated protein methyltransferase, isoprenylated protein methyltransferase, protein-s-isoprenylcysteine o-methyltransferase, isoprenylcysteine methylesterase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
isoprenylcysteine methylesterase
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farnesyl cysteine C-terminal methyltransferase
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farnesyl-protein carboxymethyltransferase
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farnesylated protein C-terminal O-methyltransferase
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isoprenylated protein methyltransferase
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isoprenylcysteine methylesterase
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methyltransferase, protein C-terminal farnesylcysteine O-
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prenylated protein methyltransferase
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protein S-farnesylcysteine C-terminal methyltransferase
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S-farnesylcysteine methyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase
C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
130731-20-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + N-acetyl-S-all trans-geranylgeranyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-all trans-geranylgeranyl-L-cysteine methyl ester
show the reaction diagram
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-
-
?
S-adenosyl-L-methionine + N-acetyl-S-trans,trans-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-trans,trans-farnesyl-L-cysteine methyl ester
show the reaction diagram
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-
-
?
S-adenosyl-L-methionine + N-acetyl-S-all trans-geranylgeranyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-all trans-geranylgeranyl-L-cysteine methyl ester
show the reaction diagram
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-
-
?
S-adenosyl-L-methionine + N-acetyl-S-trans,trans-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-trans,trans-farnesyl-L-cysteine methyl ester
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
S-adenosyl-L-methionine
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S-adenosyl-L-methionine
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ICMT isozymes is encoded by the STE14B ICMT gene
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
the enzyme is involved in the farnesyl metabolism, overview
physiological function
isoprenylcysteine methylation and demethylation positively regulate abscisic acid signaling in Arabidopsis thaliana via feedback mechanism involving demethylation and inactivation of isoprenylated negative regulators of abscisic acid signaling
metabolism
the enzyme is involved in the farnesyl metabolism, overview
physiological function
isoprenylcysteine methylation and demethylation positively regulate abscisic acid signaling in Arabidopsis thaliana via feedback mechanism involving demethylation and inactivation of isoprenylated negative regulators of abscisic acid signaling
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ICMTB_ARATH
197
3
22766
Swiss-Prot
Secretory Pathway (Reliability: 5)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
the ICMT isozyme is encoded by the STE14B ICMT gene
the ICMT isozyme is encoded by the STE14A ICMT gene
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
abscisic acid promotes abscisic acid responsiveness of plant cells via induction of ICME expression
abscisic acid promotes abscisic acid responsiveness of plant cells via induction of ICME expression
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
biotechnology
the enzyme is a target for metabolic engineering of crop species for drought tolerance by targeted alterations in isoprenylcysteine methylation
biotechnology
the enzyme is a target for metabolic engineering of crop species for drought tolerance by targeted alterations in isoprenylcysteine methylation
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Huizinga, D.H.; Omosegbon, O.; Omery, B.; Crowell, D.N.
Isoprenylcysteine methylation and demethylation regulate abscisic acid signaling in Arabidopsis
Plant Cell
20
2714-2728
2008
Arabidopsis thaliana, Arabidopsis thaliana (Q93W54)
Manually annotated by BRENDA team