BRENDA Home
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB CommentsThe enzyme uses S-adenosyl-L-methionine as methyl donor less actively than S-methyl-L-methionine.
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
homocysteine methyltransferase, homocysteine s-methyltransferase, athmt-1, homocysteine transmethylase, l-homocysteine s-methyltransferase, yagd protein, s-methylmethionine homocysteine methyltransferase, athmt-2,
morePlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
adenosylmethionine transmethylase
-
-
-
-
adenosylmethionine:homocysteine methyltransferase
-
-
-
-
homocysteine methylase
-
-
-
-
homocysteine methyltransferase
-
-
-
-
homocysteine transmethylase
-
-
-
-
L-homocysteine S-methyltransferase
-
-
-
-
methylmethionine:homocysteine methyltransferase
-
-
-
-
S-adenosyl-L-methionine:L-homocysteine methyltransferase
-
-
-
-
S-adenosylmethionine homocysteine transmethylase
-
-
-
-
S-adenosylmethionine-homocysteine transmethylase
-
-
-
-
S-adenosylmethionine:homocysteine methyltransferase
-
-
-
-
S-methylmethionine homocysteine transmethylase
-
-
-
-
AtHMT-1
-
AtHMT-1
encoded by single copy gene
AtHMT-2
-
AtHMT-2
encoded by single copy gene
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
methyl group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine:L-homocysteine S-methyltransferase
The enzyme uses S-adenosyl-L-methionine as methyl donor less actively than S-methyl-L-methionine.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
S-methyl-L-methionine + L-cysteine
?
-
-
-
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
S-methyl-L-methionine + L-homocysteine
2 L-methionine
additional information
?
-
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
-
-
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
the Km-value for S-adenosyl-L-methionine is higher than for S-methyl-L-methionine and the Vmax value is lower
-
-
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
-
-
-
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
-
-
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
-
-
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
the Km-value for S-adenosyl-L-methionine is higher than for S-methyl-L-methionine and the Vmax value is lower
-
-
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
the Km-value for S-adenosyl-L-methionine is higher than for S-methyl-L-methionine and the Vmax value is lower
-
-
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
-
-
-
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
-
-
-
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
synthesis of L-methionine from homocysteine
-
-
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
-
-
?
additional information
?
-
no activity with DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate
-
-
?
additional information
?
-
no activity with DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate
-
-
?
additional information
?
-
no activity with D-cysteine, L-cysteine, DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate
-
-
?
additional information
?
-
no activity with D-cysteine, L-cysteine, DL-selenocysteine, glutathione, coenzyme A, sulfide, or thiocyanate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
-
-
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
-
-
?
S-adenosyl-L-methionine + L-homocysteine
S-adenosyl-L-homocysteine + L-methionine
the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
-
-
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
S-methyl-L-methionine + L-homocysteine
2 L-methionine
synthesis of L-methionine from homocysteine
-
-
?
S-methyl-L-methionine + L-homocysteine
2 L-methionine
the enzyme uses S-methyl-L-methionine and S-adenosyl-L-methionine as methyl donor in vivo
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
contains a zinc-binding motif, no stimulation by 0.1 or 1 mM Zn2+
additional information
contains a zinc-binding motif, no stimulation by 0.1 or 1 mM Zn2+
additional information
contains a zinc-binding motif, no stimulation by 0.1 or 1 mM Zn2+
additional information
contains a zinc-binding motif, no stimulation by 0.1 or 1 mM Zn2+
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EDTA
1 mM, 26% inhibition
L-methionine
strong product inhibition
additional information
no product inhibition by L-methionine below 0.5 mM, no inhibition by EDTA
-
additional information
no product inhibition by L-methionine below 0.5 mM, no inhibition by EDTA
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.067 - 0.077
L-homocysteine
1.95
S-adenosyl-L-methionine
pH 7.5, 30°C
0.029
S-methyl-L-methionine
pH 7.5, 30°C
0.018 - 0.035
L-homocysteine
0.225 - 1.76
S-adenosyl-L-methionine
0.05 - 0.335
S-methyl-L-methionine
0.067
L-homocysteine
pH 7.5, 30°C, cosubstrate: S-adenosyl-L-methionine
0.077
L-homocysteine
pH 7.5, 30°C, cosubstrate: S-methyl-L-methionine
0.018
L-homocysteine
pH 7.5, 30°C, cosubstrate: S-adenosyl-L-methionine
0.027
L-homocysteine
pH 7.5, 25°C, cosubstrate: S-adenosyl-L-methionine
0.03
L-homocysteine
pH 7.5, 25°C, cosubstrate: S-methyl-L-methionine
0.035
L-homocysteine
pH 7.5, 30°C, cosubstrate: S-methyl-L-methionine
0.225
S-adenosyl-L-methionine
pH 7.5, 30°C
1.76
S-adenosyl-L-methionine
pH 7.5, 25°C
0.05
S-methyl-L-methionine
pH 7.5, 30°C
0.335
S-methyl-L-methionine
pH 7.5, 25°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
SwissProt
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
rosette leaves, cauline leaves
brenda
-
brenda
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
brenda
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
HMT1_ARATH
326
0
35980
Swiss-Prot
other Location (Reliability: 3)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
36400
1 * 36400, calculated from sequence
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
monomer
1 * 36000, calculated from sequence
monomer
1 * 36400, calculated from sequence
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression in Escherichia coli
expression in Escherichia coli
expression in Escherichia coli
expression in Escherichia coli
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ranocha, P.; Bourgis, F.; Ziemak, M.J.; Rhodes, D.; Gage, D.A.; Hanson, A.D.
Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis
J. Biol. Chem.
275
15962-15968
2000
Arabidopsis thaliana (Q9M1W4), Arabidopsis thaliana (Q9SDL7)
brenda
Ranocha, P.; McNeil, S.D.; Ziemak, M.J.; Li, C.; Tarczynski, M.C.; Hanson, A.D.
The S-methylmethionine cycle in angiosperms: ubiquity, antiquity and activity
Plant J.
25
575-584
2001
Arabidopsis thaliana (Q8LAX0)
brenda
2.1.1.10 homocysteine S-methyltransferase
top
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
