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Information on EC 1.8.98.1 - dihydromethanophenazine:CoB-CoM heterodisulfide reductase

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IUBMB Comments
This enzyme is found in methanogenic archaea, particularly Methanosarcina species, and regenerates coenzyme M and coenzyme B after the action of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. Contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters . Highly specific for both coenzyme M and coenzyme B. Reacts with various phenazine derivatives, including 2-hydroxyphenazine and 2-bromophenazine.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
heterodisulfide reductase, hdrabc, hdrc2, h2:heterodisulfide oxidoreductase, hdrc1, soluble heterodisulfide reductase, hdra2b2c2, hdrb1, hdrb2, co:com-s-s-cob oxidoreductase system, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CoB + CoM + methanophenazine = CoM-S-S-CoB + dihydromethanophenazine
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highly specific; This enzyme is found in methanogenic archaea, particularly Methanosarcina species, and regenerates coenzyme M and coenzyme B after the action of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. Contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters. Highly specific for both coenzyme M and coenzyme B. Reacts with various phenazine derivatives, including 2-hydroxyphenazine and 2-bromophenazine
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