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Information on EC 1.8.98.1 - dihydromethanophenazine:CoB-CoM heterodisulfide reductase

for references in articles please use BRENDA:EC1.8.98.1

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IUBMB Comments

This enzyme, found in methanogenic archaea that belong to the Methanosarcinales order, regenerates CoM and CoB after the action of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It is a membrane-bound enzyme that contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase and EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
heterodisulfide reductase, hdrabc, hdrc2, h2:heterodisulfide oxidoreductase, hdra2b2c2, hdrc1, soluble heterodisulfide reductase, hdrb1, hdrb2, co:com-s-s-cob oxidoreductase system, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CoB + CoM + methanophenazine = CoM-S-S-CoB + dihydromethanophenazine
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
coenzyme B/coenzyme M regeneration I (methanophenazine-dependent)