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Information on EC 1.8.5.4 - bacterial sulfide:quinone reductase
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1.8.5.4 bacterial sulfide:quinone reductaseIUBMB Comments
Contains FAD. Ubiquinone, plastoquinone or menaquinone can act as acceptor in different species. In some organisms the enzyme catalyses the formation of sulfur globules. It repeats the catalytic cycle without releasing the product, producing a polysulfide of up to 10 sulfur atoms. The reaction stops when the maximum length of the polysulfide that can be accommodated in the sulfide oxidation pocket is achieved. The enzyme also plays an important role in anoxygenic bacterial photosynthesis. cf. EC 1.8.5.8, sulfide quinone oxidoreductase.
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Word Map
- 1.8.5.4
- sulfur
- h2s
- thiosulfate
- persulfide
- polysulfide
- acidithiobacillus
- sulfurtransferase
-
sulfide-oxidizing
- rhodanese
-
sulfane
- ferrooxidans
- 3-mercaptopyruvate
-
anoxygenic
-
sulfur-oxidizing
-
chemolithotrophic
-
sulfide-dependent
-
echiuran
- unicinctus
- limnetica
-
urechis
-
monotopic
- oscillatoria
- tepidum
- chlorobaculum
-
sulfide-rich
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
sulfide:quinone oxidoreductase, sulfide quinone oxidoreductase, sqrdl, sulfide quinone reductase, sulfide-quinone reductase, sulfide-quinone oxidoreductase, ct1087, trsqrf, iii sqr, cpsqr, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CmSQR
HMT2
III SQR
SQR
Sqrdl
Suden_1879
Suden_2082
Suden_619
sulfide quinone oxidoreductase
sulfide-quinone oxidoreductase
sulfide-quinone reductase
sulfide: quinone oxidoreductase
sulfide:decylubiquinone oxidoreductase
sulfide:quinone oxidoreductase
sulfidequinone reductase-like protein
type III sulfide:quinone oxidoreductase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
n HS- + n quinone = polysulfide + n quinol
-
-
-
-
n HS- + n quinone = polysulfide + n quinol
reaction mechanism, overview
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
sulfide:quinone oxidoreductase
Contains FAD. Ubiquinone, plastoquinone or menaquinone can act as acceptor in different species. In some organisms the enzyme catalyses the formation of sulfur globules. It repeats the catalytic cycle without releasing the product, producing a polysulfide of up to 10 sulfur atoms. The reaction stops when the maximum length of the polysulfide that can be accommodated in the sulfide oxidation pocket is achieved. The enzyme also plays an important role in anoxygenic bacterial photosynthesis. cf. EC 1.8.5.8, sulfide quinone oxidoreductase.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
n Na2S + n decylubiquinone
polysulfide + n decylubiquinol + 2 Na+
-
-
-
-
?
Na2S + duroquinone
polysulfide + duroquinol + 2 Na+
-
-
-
?
sulfide + 2,3-dimethyl-1,4-naphthoquinone
sulfur + 2,3-dimethyl-1,4-naphthoquinol
-
-
-
-
?
sulfide + 2-methyl-3-methylthio-1,4-naphthoquinone
sulfur + 2-methyl-3-methylthio-1,4-naphthoquinol
-
lowest activity
-
-
?
sulfide + cysteine + coenzyme Q1
cysteine persulfide + reduced coenzyme Q1
-
-
-
-
?
sulfide + decylubiquinone + cyanide
sulfur + decylubiquinol + thiocyanate
-
-
-
-
?
sulfide + decylubiquinone + Escherichia coli thioredoxin
sulfur + decylubiquinol + ?
-
with Escherichia coli thioredoxin, SQR exhibits one-tenth of the cyanide-dependent activity
-
-
?
sulfide + decylubiquinone + sulfite
sulfur + decylubiquinol + ?
-
with sulfite, SQR exhibits one-tenth of the cyanide-dependent activity
-
-
?
sulfide + duroquinone 23
sulfur + duroquinol 23
-
% compared to the activity with decylubiquinone
-
-
?
sulfide + homocysteine + coenzyme Q1
homocysteine persulfide + reduced coenzyme Q1
-
-
-
-
?
sulfide + menadione
polysulfide + menadiol
-
25% compared to the activity with decylubiquinone
-
-
?
sulfide + plastoquinone-2
sulfur + plastoquinol-2
-
highest activity
-
-
?
sulfide + reduced glutathione + coenzyme Q1
glutathione persulfide + reduced coenzyme Q1
-
-
-
-
?
sulfide + sulfide + coenzyme Q
hydrogen disulfide + reduced coenzyme Q
-
-
-
?
n S2- + n decylubiquinone
polysulfide + n decylubiquinol
-
Na2S
-
-
?
n S2- + n decylubiquinone
polysulfide + n decylubiquinol
-
Na2S
-
-
?
sulfide + decylubiquinone
polysulfide + decylubiquinol
-
-
-
-
?
sulfide + decylubiquinone
polysulfide + decylubiquinol
-
-
-
-
?
sulfide + decylubiquinone
sulfur + decylubiquinol
-
-
-
?
sulfide + decylubiquinone
sulfur + decylubiquinol
-
-
-
?
sulfide + decylubiquinone
sulfur + decylubiquinol
-
-
-
-
?
sulfide + duroquinone
sulfur + duroquinol
-
23% compared to the activity with decylubiquinone
-
-
?
sulfide + duroquinone
sulfur + duroquinol
-
23% compared to the activity with decylubiquinone
-
-
?
sulfide + menadione
sulfur + menadiol
-
25% compared to the activity with decylubiquinone
-
-
?
sulfide + menadione
sulfur + menadiol
-
25% compared to the activity with decylubiquinone
-
-
?
sulfide + ubiquinone-1
sulfur + ubiquinol-1
-
15% compared to the activity with decylubiquinone
-
-
?
sulfide + ubiquinone-1
sulfur + ubiquinol-1
-
15% compared to the activity with decylubiquinone
-
-
?
additional information
?
-
the enzymatic reaction catalyzed by sulfide:quinone oxidoreductase includes the oxidation of sulfide compounds H2S, HS-, and S2- to soluble polysulfide chains or to elemental sulfur in the form of octasulfur rings
-
-
?
additional information
?
-
-
the enzymatic reaction catalyzed by sulfide:quinone oxidoreductase includes the oxidation of sulfide compounds H2S, HS-, and S2- to soluble polysulfide chains or to elemental sulfur in the form of octasulfur rings
-
-
?
additional information
?
-
-
quinone binding site structure analysis and binding mechanism by CmSQR, overview
-
-
-
additional information
?
-
-
quinone binding site structure analysis and binding mechanism by CmSQR, overview
-
-
-
additional information
?
-
-
no activity with vitamin K1
-
-
?
additional information
?
-
cyanide, sulfite, or sulfide can act as the sulfane sulfur acceptor in reactions that exhibit pH optima at 8.5, 7.5, or 7.0, respectively, and produce thiocyanate, thiosulfate, or a putative sulfur analogue of hydrogen peroxide, i.e. H2S2, respectively. Sulfite is the physiological acceptor of the sulfur and the reaction is the predominant source of the thiosulfate produced during H2S oxidation by mammalian tissues
-
-
?
additional information
?
-
-
cyanide, sulfite, or sulfide can act as the sulfane sulfur acceptor in reactions that exhibit pH optima at 8.5, 7.5, or 7.0, respectively, and produce thiocyanate, thiosulfate, or a putative sulfur analogue of hydrogen peroxide, i.e. H2S2, respectively. Sulfite is the physiological acceptor of the sulfur and the reaction is the predominant source of the thiosulfate produced during H2S oxidation by mammalian tissues
-
-
?
additional information
?
-
SQR oxidizes sulfide to polysulfide, which spontaneously reacts with glutathione (GSH) to produce glutathione persulfide (GSSH), PDO oxidizes GSSH to sulfite, which spontaneously reacts with polysulfide to produce thiosulfate
-
-
-
additional information
?
-
sulfide-dependent duroquinone-reducing activity of purified wild-type and single cysteine mutant TrSqrF variants, overview
-
-
-
additional information
?
-
-
sulfide-dependent duroquinone-reducing activity of purified wild-type and single cysteine mutant TrSqrF variants, overview
-
-
-
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
cyanide, sulfite, or sulfide can act as the sulfane sulfur acceptor in reactions that exhibit pH optima at 8.5, 7.5, or 7.0, respectively, and produce thiocyanate, thiosulfate, or a putative sulfur analogue of hydrogen peroxide, i.e. H2S2, respectively. Sulfite is the physiological acceptor of the sulfur and the reaction is the predominant source of the thiosulfate produced during H2S oxidation by mammalian tissues
-
-
?
additional information
?
-
-
cyanide, sulfite, or sulfide can act as the sulfane sulfur acceptor in reactions that exhibit pH optima at 8.5, 7.5, or 7.0, respectively, and produce thiocyanate, thiosulfate, or a putative sulfur analogue of hydrogen peroxide, i.e. H2S2, respectively. Sulfite is the physiological acceptor of the sulfur and the reaction is the predominant source of the thiosulfate produced during H2S oxidation by mammalian tissues
-
-
?
additional information
?
-
SQR oxidizes sulfide to polysulfide, which spontaneously reacts with glutathione (GSH) to produce glutathione persulfide (GSSH), PDO oxidizes GSSH to sulfite, which spontaneously reacts with polysulfide to produce thiosulfate
-
-
-
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
FAD