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Information on EC 1.8.4.9 - adenylyl-sulfate reductase (glutathione)

for references in articles please use BRENDA:EC1.8.4.9

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IUBMB Comments

This enzyme differs from EC 1.8.99.2, adenylyl-sulfate reductase, in using glutathione as the reductant. Glutathione can be replaced by γ-glutamylcysteine or dithiothreitol, but not by thioredoxin, glutaredoxin or 2-sulfanylethan-1-ol (2-mercaptoethanol). The enzyme from the mouseear cress, Arabidopsis thaliana, contains a glutaredoxin-like domain. The enzyme is also found in other photosynthetic eukaryotes, e.g., the Madagascar periwinkle, Catharanthus roseus and the hollow green seaweed, Ulva intestinalis.

The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria

Synonyms
adenosine-5'-phosphosulfate reductase, apr1p, adenosine-5'-phosphosulphate reductase, adenosine 5-phosphosulfate reductase, eiapr, ppapr-b, prh-19, prh-26, prh-43, atapr1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
AMP + sulfite + glutathione disulfide = adenylyl sulfate + 2 glutathione
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
assimilatory sulfate reduction II, selenate reduction
Highest Expressing Human Cell Lines
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