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Information on EC 1.8.4.7 - enzyme-thiol transhydrogenase (glutathione-disulfide)

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IUBMB Comments
Converts EC 1.17.1.4 xanthine dehydrogenase into EC 1.17.3.2 xanthine oxidase in the presence of glutathione disulfide; also reduces the disulfide bond of ricin. Not inhibited by Cu2+ or thiol reagents.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
DnaJ, enzyme-thiol transhydrogenase (oxidized glutathione), glutathione-dependent thiol:disulfide oxidoreductase, thiol-disulfide oxidoreductase, thiol:disulfide oxidoreductase, thiol:disulphide oxidoreductase, YkuV, [xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[xanthine dehydrogenase] + glutathione disulfide = [xanthine oxidase] + 2 glutathione
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PATHWAY SOURCE
PATHWAYS
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