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Information on EC 1.8.1.5 - 2-oxopropyl-CoM reductase (carboxylating)

for references in articles please use BRENDA:EC1.8.1.5

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IUBMB Comments

Also acts on thioethers longer in chain length on the oxo side, e.g. 2-oxobutyl-CoM, but this portion must be attached to CoM (2-mercaptoethanesulfonate); no CoM analogs will substitute. This enzyme forms component II of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.

The enzyme appears in viruses and cellular organisms

Synonyms
2-kpcc, nadph:2-ketopropyl-coenzyme m oxidoreductase/carboxylase, 2-ketopropyl-coenzyme m oxidoreductase/carboxylase, 2-ketopropyl coenzyme m oxidoreductase/carboxylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-mercaptoethanesulfonate + acetoacetate + NADP+ = 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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