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Information on EC 1.8.1.12 - trypanothione-disulfide reductase

for references in articles please use BRENDA:EC1.8.1.12

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IUBMB Comments

Trypanothione disulfide is the oxidized form of N1,N6-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. The enzyme from Crithidia fasciculata is a flavoprotein (FAD), whose activity is dependent on a redox-active cystine at the active centre. (cf. EC 1.8.1.7, glutathione-disulfide reductase)

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
trypanothione reductase, li-tryr, ldtryr, trypanothione disulfide reductase, lbtryr, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS