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Information on EC 1.7.3.3 - factor-independent urate hydroxylase

for references in articles please use BRENDA:EC1.7.3.3

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IUBMB Comments

This enzyme was previously thought to be a copper protein, but it is now known that the enzymes from soy bean (Glycine max), the mould Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalysed pathway in which EC 3.5.2.17, hydroxyisourate hydrolase, catalyses the first step. The enzyme is different from EC 1.14.13.113 (FAD-dependent urate hydroxylase).

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes

Synonyms
uricase, rasburicase, urate oxidase, uricase ii, uric acid oxidase, uricozyme, aguox, nodulin 35, elitek, urate:oxygen oxidoreductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
urate + O2 + H2O = 5-hydroxyisourate + H2O2
show the reaction diagram