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Information on EC 1.7.1.16 - nitrobenzene nitroreductase

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IUBMB Comments
Contains FMN. The enzyme, characterized from Pseudomonas species, catalyses two successive reductions of nitrobenzene, via a nitrosobenzene intermediate. It is also active on 1-chloro-4-nitrobenzene.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
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Synonyms
cnbA, NbzA, NfsB, Oxygen-insensitive NAD(P)H nitroreductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N-phenylhydroxylamine + 2 NADP+ + H2O = nitrobenzene + 2 NADPH + 2 H+
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overall reaction
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N-phenylhydroxylamine + NADP+ = nitrosobenzene + NADPH + H+
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(1a)
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nitrosobenzene + NADP+ + H2O = nitrobenzene + NADPH + H+
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(1b)
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