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Information on EC 1.6.5.5 - NADPH:quinone reductase and Organism(s) Agaricus bisporus and UniProt Accession P38230

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IUBMB Comments
A zinc enzyme, specific for NADPH. Catalyses the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates . Dicoumarol [cf. EC 1.6.5.2 NAD(P)H dehydrogenase (quinone)] and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O2 . In some mammals, the enzyme is abundant in the lens of the eye, where it is identified with the protein zeta-crystallin.
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Agaricus bisporus
UNIPROT: P38230
Word Map
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
ArsH, Dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate) (quinone), DT-diaphorase, EC 1.6.99.2, Flavoprotein NAD(P)H:quinone reductase, Menadione oxidoreductase, Menadione reductase, NAD(P)H dehydrogenase, NAD(P)H dehydrogenase (quinone), NAD(P)H menadione reductase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate) (quinone)
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DT-diaphorase
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Flavoprotein NAD(P)H:quinone reductase
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Menadione oxidoreductase
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Menadione reductase
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NAD(P)H dehydrogenase
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NAD(P)H dehydrogenase (quinone)
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NAD(P)H menadione reductase
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NAD(P)H quinone reductase
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NAD(P)H-quinone dehydrogenase
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NAD(P)H-quinone oxidoreductase
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NAD(P)H-quinone reductase
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NAD(P)H:(quinone-acceptor) oxidoreductase
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NAD(P)H:menadione oxidoreductase
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NAD(P)H:paraquat diaphorase
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NADH-menadione reductase
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NADH-menaquinone reductase
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NADH:quinone reductase
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NADPH DT-diaphorase
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NADPH:quinone oxidoreductase
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NADPH:quinone reductase
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Naphthoquinone reductase
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p-Benzoquinone reductase
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P36
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Phylloquinone reductase
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Quinone reductase
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Reduced NAD(P)H dehydrogenase
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Viologen accepting pyridine nucleotide oxidoreductase
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Vitamin K reductase
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zeta-Crystallin
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zeta-crystallin homolog protein
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zeta-crystallin/NADPH:quinone oxidoreductase
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zeta-Crystallin/quinone reductase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
NADPH:quinone oxidoreductase
A zinc enzyme, specific for NADPH. Catalyses the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates [1]. Dicoumarol [cf. EC 1.6.5.2 NAD(P)H dehydrogenase (quinone)] and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O2 [1]. In some mammals, the enzyme is abundant in the lens of the eye, where it is identified with the protein zeta-crystallin.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-20-6
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