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Information on EC 1.6.5.4 - monodehydroascorbate reductase (NADH)
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1.6.5.4 monodehydroascorbate reductase (NADH)Specify your search results
Word Map
- 1.6.5.4
- dismutase
- catalase
- aureus
- staphylococcus
- amp
- sod
- seedling
- mucosal
- gsh
-
cysteine-rich
-
ascorbate-glutathione
-
paneth
-
bactericidal
- chlorophyll
-
jasmonic
- lysozyme
- malondialdehyde
- cathelicidins
- mosquito
- fusarium
- hemocytes
-
microbicidal
-
cecropins
- crohn
- hemolymph
- tick
- midguts
- guaiacol
- aegypti
- anopheles
- cinerea
- scorpion
- botrytis
- aedes
-
necrotrophic
-
1.11.1.11
- mussel
-
pathogenesis-related
-
toll
- oxysporum
-
1.6.4.2
- gambiae
-
azurophilic
- glyoxalase
- mellifera
-
periprosthetic
- brassicicola
-
raphanus
- dermacentor
-
triple-stranded
- agriculture
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
defensin, monodehydroascorbate reductase, mdhar, mdar, afr reductase, mda reductase, ascorbate free radical reductase, trx h2, semidehydroascorbate reductase, monodehydroascorbate radical reductase, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AFR-reductase
-
-
-
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ascorbate free radical reductase
ascorbate free-radical reductase
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-
-
-
ascorbic free radical reductase
-
-
-
-
MDA reductase
MDAR
MDAsA reductase (NADPH)
-
-
-
-
MDHA
-
-
-
-
MDHAR
MDHAR1
metallothionein-like type 1 protein
monodehydroascorbate radical reductase
monodehydroascorbate reductase
MT-2
MT1K
NADH-semidehydroascorbate oxidoreductase
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-
-
-
NADH:AFR oxidoreductase
-
-
-
-
NADH:ascorbate radical oxidoreductase
-
-
-
-
NADH:semidehydroascorbic acid oxidoreductase
-
-
-
-
SDA reductase
-
-
-
-
semidehydroascorbate reductase
-
-
-
-
SOR
-
-
-
-
additional information
enzyme is bifunctional showing monodehydroascorbate reductase and carbonic anhydrase, EC 4.2.1.1, activities
ascorbate free radical reductase
-
-
-
-
MDA reductase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate
-
-
-
-
NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate
ping-pong mechanism
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NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate
ping pong mechanism
-
NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate
ping pong mechanism
-
NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate
PpMDHARs follow a ping-pong kinetic mechanism
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
NADH:monodehydroascorbate oxidoreductase
-
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CAS REGISTRY NUMBER
COMMENTARY
9029-26-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
-
enzyme also shows diaphorase activity, i.e. ferricyanide reductase
-
-
?
CO2 + H2O
HCO3- + H+
bifunctional enzyme showing monodehydroascorbate reductase and carbonic anhydrase, EC 4.2.1.1, activities
-
-
?
ferricyanide + reduced 2,6-dichlorophenolindophenol
ferrocyanide + 2,6-dichlorophenolindophenol
-
enzyme also shows diaphorase activity, i.e. ferricyanide reductase
-
-
?
NAD(P)H + monodehydroascorbate
NAD(P)+ + ascorbate
-
reduction of the radical monodehydroascorbate, via FAD as intermediary electron acceptor, FAD reduction by NADH producing a charge-transfer complex
-
-
?
NADH + H+ + oxidized 2,6-dichlorophenolindophenol
NAD+ + reduced 2,6-dichlorophenolindophenol
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-
-
-
r
monodehydroascorbate + NADH + H+
ascorbate + NAD+
-
-
-
?
NADH + 2,6-dichlorophenol indophenol
NAD+ + ?
-
about 10% of the activity with monodehydroascorbate radical
-
-
?
NADH + H+ + 2 monodehydroascorbate
NAD+ + 2 ascorbate
-
-
-
-
?
NADH + H+ + 2 monodehydroascorbate
NAD+ + 2 ascorbate
-
-
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
enzyme is involved in the ascorbate-glutathione cycle together with EC 1.8.5.1, and EC 1.6.4.2
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the monodehydroascorbate radical reacts with the fully reduced form of the enzyme with a diffusion-controlled rate
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
key enzyme for maintaining the ascorbic acid system in the reduced state
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-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
enzyme of the ascorbate-glutathione cycle
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-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
enzyme may constitute part of cellular mechanisms which protect against and repair oxidant injury to biomolecules
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
enzyme is responsible for maintaining ascorbate concentrations in nectar
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
key enzyme in maintaining reduced pools of ascorbate
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-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
Pterocladia sp.
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the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
-
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in part of the transplasmamembrane redox system
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme supports cholesterol side chain cleavage, the enzyme functions to provide cytoplasmic reducing equivalents to intramitochondrial cytochrome P-450SCC
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the only physiologically important system for the regeneration of ascorbate
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
involvement of semidehydroascorbate reductase in the oxidation of NADH by lipid peroxide in mitochondria and microsomes
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme sustains glyoxysomal NAD+ during beta-oxidation, the glyoxylate cycle and gluconeogenesis in the endosperm during germination
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
-
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
enzyme participates in the regeneration of ascorbate for scavenging toxic oxygen species in potato tuber mitochondria
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-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
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the enzyme is an effective scavenger of the monodehydroascorbate radical
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-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADPH + H+ + 2 monodehydroascorbate
NADP+ + 2 ascorbate
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-
-
-
?
NADPH + monodehydroascorbate
NADP+ + ascorbate
NADH is the preferred electron donor
-
-
?
additional information
?
-
-
enzyme is also capable of reducing phenoxyl radicals which are generated by horseradish peroxidase with H2O2
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-
?
additional information
?
-
metallothionein-lke protein MT1K shows both dehydroascorbate reductase EC 1.8.5.1, and monodehydroascorbate reductase activity
-
-
?
additional information
?
-
metallothionein-lke protein MT1K shows both dehydroascorbate reductase EC 1.8.5.1, and monodehydroascorbate reductase activity
-
-
?
additional information
?
-
-
metallothionein-lke protein MT1K shows both dehydroascorbate reductase EC 1.8.5.1, and monodehydroascorbate reductase activity
-
-
?
additional information
?
-
metallothionein-lke protein MT1K shows both dehydroascorbate reductase EC 1.8.5.1, and monodehydroascorbate reductase activity
-
-
?
additional information
?
-
metallothionein-lke protein MT1K shows both dehydroascorbate reductase EC 1.8.5.1, and monodehydroascorbate reductase activity
-
-
?
additional information
?
-
reaction scheme, the enzyme is involved in nectary production in floral organs, multiple molecular mechanism responsible for expression in the nectary gland
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CO2 + H2O
HCO3- + H+
bifunctional enzyme showing monodehydroascorbate reductase and carbonic anhydrase, EC 4.2.1.1, activities
-
-
?
additional information
?
-
reaction scheme, the enzyme is involved in nectary production in floral organs, multiple molecular mechanism responsible for expression in the nectary gland
-
-
?
NADH + H+ + 2 monodehydroascorbate
NAD+ + 2 ascorbate
-
-
-
-
?
NADH + H+ + 2 monodehydroascorbate
NAD+ + 2 ascorbate
-
-
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
the enzyme is involved in maintaining the ascorbic acid system in the reduced state
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
enzyme is involved in the ascorbate-glutathione cycle together with EC 1.8.5.1, and EC 1.6.4.2
-
-
?
NADH + monodehydroascorbate
NAD+ + ascorbate
-
key enzyme for maintaining the ascorbic acid system in the reduced state
-
-
?