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industry
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mice lacking the NAD(P)H oxidase gp91phox subunit respond to exposure to single-walled carbon nanotubes with a marked accumulation of polymorphnuclear neutrophils and elevated levels of apoptotic cells in the lungs, production of pro-inflammatory cytokines, decreased production of the anti-inflammatory and pro-fibrotic cytokine, TGF-beta, and significantly lower levels of collagen deposition
additional information
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NADPH oxidase but not myeloperoxidase is required for host defense in lymphopenic mice. Lymphocytes and NADPH oxidase may compensate for each other's deficiency in providing resistance to spontaneous bacterial infections
medicine
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after myocardial infarction, NAD(P)H oxidase activity is markedly increased in remote left ventricular myocardium of wild-type mice but not in mice deficient in subunit p47phox. Increased myocardial xanthine oxidase activity is observed in wild-type, but not in p47phox-deficient mice after myocardial infarction. Left ventricular cavity dilatation and dysfunction 4 weeks after infarction are markedly attenuated in p47phox-deficient mice and cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis are substantially reduced as compared with wild-type. The survival rate is markedly higher in mice deficient in subunit p47phox
medicine
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application of HIV regulatory protein Tat to microglia or macrophages causes dose- and time-dependent increases in superoxide formation that are prevented by both pharmacologic NADPH oxidase inhibitors and by specific decoy peptides gp91ds. Inhibition of NADPH oxidase attenuates Tat-induced release of IL-6 and TNFalpha, and MCP-1, and decreases microglial-mediated neurotoxicity. Macrophages derived from NADPH oxidase deficient mice display reduced superoxide production, released lower levels of cytokines/chemokines, and induce less neurotoxicity in response to Tat compared to wild-type macrophages
medicine
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characterization of mutant V674G. Thyroid glands of mutant mice are goitrous and contain few normal follicles, anterior pituitaries are dysplastic. Serum thyroxine in homozygotes is about one-tenth the level of controls.. the weight of adult mutant mice is approximately half that of littermate controls, and serum IGF-I is reduced. The cochleae of mutant mice exhibit abnormalities characteristic of hypothyroidism, including a delayed formation of the inner sulcus and tunnel of Corti and an abnormally thickened tectorial membrane. Hearing thresholds of adult mutant mice are on average 50-60 decibels above those of controls
medicine
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experimental model of spontaneous intracranial hemorrhage in transgenic mice expressing human renin and human angiotensinogen treated with high-salt diet and Nomega-nitro-L-arginine methyl ester. In these mice, NAD(P)H oxidase activity is significantly increased. Increased enzyme activity preceeds signs of spontaneous intracranial hemorrhage and increases further whith development of intracranial hemorrhage
medicine
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hydrophobic, proapoptotic bile salts induce hepatocyte shrinkage largely through NADPH oxidase-derived oxidative stress. Because cell shrinkage in turn activates NADPH oxidase, which blunts cell volume recovery, a vicious cycle ensues between oxidative stress and cell shrinkage, which propagates CD95 activation and may finally lead to apoptosis
medicine
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hypoxic conditions lead to upregulation exclusively of NOX4 mRNA in lung, concomitant with increased levels in microdissected pulmonary arterial vessels. NOX4 mRNA and protein are localized predominantly in the media of small pulmonary arteries, with increased labeling intensities after chronic exposure to hypoxia. In isolated pulmonary arterial smooth muscle cells, NOX4 is localized primarily to the perinuclear space
medicine
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in obese, diabetic, leptin-receptor deficient db-/db- mice, mRNA levels of enzyme subunits Nox-1, Nox-2, and Nox-4 as well as Nox-2 protein expression are elevated, whereas aortic Cu/Zn superoxide dismutase protein and PPARgamma mRNA levels are reduced
medicine
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increased oxidative stress in the vasculature of streptozotocin-induced diabetic apoE-deficient mice is linked to changes in endothelial nitric oxide synthase, superoxide dismutase and NADPH oxidase expression
medicine
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increases in myocardial serine-threonine kinase Akt and ERK1/2 activation and vascular endothelial growth factor expression are markedly blunted in the subunit p47phox-deficient mouse subjected to myocardial ischemia-reperfusion compared with the wild-type mouse
medicine
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induction of sterile hyperinflammation by injection of fungal cell wall preparations in chronic granulomatous disease mouse model. Preparations from Aspergillus fumigatus, Candida albicans, or Saccharomyces cerevisiae cause prolonged and severe skin inflammation, but not preparations from bacteria such as Staphylococcus aureus, Pseudomonas aerginosa, or Escherichia coli. Components most responsible for the inflammatory effect are branched fungal beta-glucans
medicine
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induction of superoxide production by doxorubicin is much higher in hearts of wild-type mice than in subunit gp91phox knock-out mice. Superoxide production is similarly induced by addition of NADPH cytochrome P450 reductase
medicine
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inhibition of NAD(P)H oxidase by apocynin in ischemia-induced mice prevents blood-brain barrier damage in the ischemic hemisphere I after reperfusion. In mice deficient in subunit gp91phox, middle cerebral artery occlusion-induced blood-brain barrier disruption and lesion volume in ischemia-induced animals are largely attenuated. Activation of NAD(P)H oxidase promotes cerebral reactive oxygen species formation, which then leads to Rho kinase-mediated endothelial cell contraction and disruption of the blood-brain barrier
medicine
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isoform Nox4 is expressed at high levels in white and brown preadipocytes. Differentiation into adipocytes results in a decrease in their NOX4 mRNA content. In intact adipose tissue, the majority of NOX4 expressing cells are localized within the preadipocyte containing stromal/vascular fracftion. Alterations in NOX4 expression reflects changes in the ratio of adipocyte/interstitial fractions
medicine
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mice deficient in NAD(P)H oxidase p47phox show an increase of 17% of the area occupied by airway smooth muscle cells in trachea, compared with wild-type. They exhibit a significantly reduced airway smooth muscle cell relaxation during electric field stimulation and after the end of stimulation. NAD(P)H oxidase may have a role in the structural arrangement and mechanical properties of the airway tissue
medicine
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mice lacking the NAD(P)H oxidase gp91phox subunit respond to exposure to single-walled carbon nanotubes with a marked accumulation of polymorphnuclear neutrophils and elevated levels of apoptotic cells in the lungs, production of pro-inflammatory cytokines, decreased production of the anti-inflammatory and pro-fibrotic cytokine, TGF-beta, and significantly lower levels of collagen deposition
medicine
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N-[2-(4-hydroxy-phenyl)-ethyl]-2-(2, 5-dimethoxy-phenyl)-3-(3-methoxy-4-hydroxy-phenyl)-acrylamide i.e. FLZ, squamosamide derivative. FLZ inhibits the translocation of the cytosolic subunit p47phox to the membrane and thus inhibits the activation of NAD(P)H oxidase. In vivo, FLZ significantly protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced dopaminergic neuronal loss
medicine
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neutrophil cytosolic factor 1-deficient mice lacking functional NADPH oxidase are resistant to skin blistering by the passive transfer of antibodies against type VII collagen. Recruitment of granulocytes into the skin is required for tissue injury, as demonstrated by the resistance to experimental blistering of wild-type mice depleted of neutrophils and of CD18-deficient mice. Granulocyte-derived NADPH oxidase is a key molecular effector engaged by pathogenic autoantibodies and provides relevant targets for prevention of tissue damage in granulocyte-mediated autoimmune diseases
medicine
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neutropjhil NAD(P)H oxidase activation, induced by hemorrhagic shock/resuscitation and as mediated by high-mobility group box HMGB1/TLR4 signaling, is an important mechanism responsible for hemorrhagic shock/resuscitation-mediated inflammation and organ injury after hemorrhage
medicine
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pivotal role of myeloid Src family kinases and complement receptor 3 in mounting an effective defense against infection with Streptococcus pneumonia by regulating phagocytosis and NADPH oxidase-dependent superoxide production. Leukocyte recruitment into the cerebrospinal fluid space and bacterial clearance is hampered in mice deficient in all three myeloid Src family kinases during pneumococcal meningitis. The mice develop increased intracranial pressure and a worse clinical outcome with increased neurologic deficits and mortality, compared with wildtype mice. In neutrophils of mice deficient for myeloid Src family kinases p59/61hck, p58c-fgr, and p53/56lyn, phosphorylation of NAD(P)H oxidase subunit p40phox is absent, indicating a defect in enzyme activation
medicine
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platelets and leukocytes from high cholesterol-fed mice exhibit elevated generation of reactive oxygen species compared to normal diet mice. Hypercholesterolemia-induced leukocyte recruitment is attenuated in Cu,Zn-superoxide dismutase transgenic, and NAD(P)H oxidase-knockout mice on high cholesterol diet. Platelets from NAD(P)H oxidase-knockout mice on high cholesterol diet exhibit low levels of adhesion comparable to those of wild-type on normal diet. Overexpression of Cu,Zn-superoxide dismutase or, to a lesser extent, NAD(P)H oxidase subunit gp91 deficiency restores arteriolar vasorelaxation responses toward normal diet wild-type levels
medicine
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reactive oxygen species produced upstream of Ca2+ influx by NADPH oxidase and downstream of Ca2+ influx by the mitochondria regulate the proinflammatory response of mast cells
medicine
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treatment of fibroblasts with tumor necrosis factor induces the formation of a signaling complex containing TNF-R1-associated death domain protein TRADD, receptor interacting protein RIP1, NAD(P)H oxidase Nox1, and the small GTPase Rac1. Formation of this complex plays a key role in tumor necrosis factor-induced necrotic cell death
medicine
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vascular cell adhesion molecule-1 induction of NADPH oxidase in the endothelium is necessary for the eosinophil recruitment during allergic inflammation
medicine
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wild-type mice fed with high-cholesterol diet exhibit impaired endothelium-dependent vasodilation, enhanced superoxide generation, and increased expression of NAD(P)H oxidase subunit Nox-2 mRNA. In severe combined immunodeficient mice, in mice genetically deficient for interferon IFN-gamma, and CD4+ T-lymphocyte-deficient mice, the impaired endothelium-dependent vasodilation and enhanced superoxide generation are significantly blunted. Effects are similar in high-cholesterol fed mice genetically deficient in NAD(P)H oxidase subunit Nox-2
medicine
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wild-type mice with myocardial infarction display significantly increased gp91phox and 3-nitrotyrosine in the infarcted myocardium, accumulated macrophages and myofibroblasts at the infarct site, abundant apoptotic myocytes primarily at border zones on day 3, and numerous apoptotic inflammatory/myofibroblasts in the later stages. Transforming growth factor 1, tissue inhibitor of metalloprotease 2, and type 1 collagen gene expression is increased, collagen volume in the infarcted myocardium continuously increases, and noninfarcted myocardium displays hypertrophy. Compared to wild-type mice with myocardial infarction, subunit gp91phox knockout mice do not display significant difference in infarct size/thickness, cardiac hypertrophy, myocyte apoptosis, inflammatory/fibrogenic responses, as well as cardiac oxidative stress
medicine
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as NAD(P)H oxidase activation may have dual actions in diabetes, selective targeting of the deleterious effects of sustained NAD(P)H oxidase activation, such as eNOS uncoupling, mitochondrial dysfunction, and impaired antioxidant gene expression, may prove beneficial in the treatment of diabetes
medicine
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NADPH oxidase type 4 is a major source of oxidative stress and an effective therapeutic target in acute stroke
medicine
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in apolipoprotein E-knockout mice, aequous extract of Tessaria absinthioides and Prosopis strombulifera significantly reduce triglycerides and lipid peroxidation, increase plasma total antioxidant status, and improve glutathione peroxidase activity in the liver. Under high-fat diet, both extracts are able to inhibit O2 anion generation in the aortic tissue and cause a significant regression of atheroma plaques
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Banfi, B.; Clark, R.A.; Steger, K.; Krause, K.H.
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1
J. Biol. Chem.
278
3510-3513
2003
Mus musculus (Q8CIZ9)
brenda
Banfi, B.; Malgrange, B.; Knisz, J.; Steger, K.; Dubois-Dauphin, M.; Krause, K.H.
NOX3, a superoxide-generating NADPH oxidase of the inner ear
J. Biol. Chem.
279
46065-46072
2004
Mus musculus (Q672J9), Rattus norvegicus (Q672K1)
brenda
Hidalgo, C.; Sanchez, G.; Barrientos, G.; Aracena-Parks, P.
A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S -glutathionylation
J. Biol. Chem.
281
26473-26482
2006
Mus musculus
brenda
Chen, J.X.; Zeng, H.; Tuo, Q.H.; Yu, H.; Meyrick, B.; Aschner, J.L.
NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation
Am. J. Physiol. Heart Circ. Physiol.
292
H1664-H1674
2007
Mus musculus, Sus scrofa
brenda
Wolfort, R.M.; Stokes, K.Y.; Granger, D.N.
CD4+ T lymphocytes mediate hypercholesterolemia-induced endothelial dysfunction via a NAD(P)H oxidase-dependent mechanism
Am. J. Physiol. Heart Circ. Physiol.
294
H2619-H2626
2008
Mus musculus
brenda
Abdala-Valencia, H.; Earwood, J.; Bansal, S.; Jansen, M.; Babcock, G.; Garvy, B.; Wills-Karp, M.; Cook-Mills, J.M.
Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma
Am. J. Physiol. Lung Cell. Mol. Physiol.
292
L1111-L1125
2007
Mus musculus
brenda
Chitano, P.; Wang, L.; Mason, S.N.; Auten, R.L.; Potts, E.N.; Foster, W.M.; Sturrock, A.; Kennedy, T.P.; Hoidal, J.R.; Murphy, T.M.
Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase
Am. J. Physiol. Lung Cell. Mol. Physiol.
294
L139-L148
2008
Mus musculus
brenda
Turchan-Cholewo, J.; Dimayuga, V.M.; Gupta, S.; Gorospe, R.M.; Keller, J.; Bruce-Keller, A.J.
NADPH oxidase drives cytokine and neurotoxin release from microglia and macrophages in response to HIV-Tat
Antioxid. Redox Signal.
11
193-204
2008
Mus musculus
brenda
Ostanin, D.V.; Barlow, S.; Shukla, D.; Grisham, M.B.
NADPH oxidase but not myeloperoxidase protects lymphopenic mice from spontaneous infections
Biochem. Biophys. Res. Commun.
355
801-806
2007
Mus musculus
brenda
Catarzi, S.; Giannoni, E.; Favilli, F.; Meacci, E.; Iantomasi, T.; Vincenzini, M.T.
Sphingosine 1-phosphate stimulation of NADPH oxidase activity: relationship with platelet-derived growth factor receptor and c-Src kinase
Biochim. Biophys. Acta
1770
872-883
2007
Mus musculus
brenda
Mouche, S.; Mkaddem, S.B.; Wang, W.; Katic, M.; Tseng, Y.H.; Carnesecchi, S.; Steger, K.; Foti, M.; Meier, C.A.; Muzzin, P.; Kahn, C.R.; Ogier-Denis, E.; Szanto, I.
Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation
Biochim. Biophys. Acta
1773
1015-1027
2007
Mus musculus
brenda
Inoue, T.; Suzuki, Y.; Yoshimaru, T.; Ra, C.
Reactive oxygen species produced up- or downstream of calcium influx regulate proinflammatory mediator release from mast cells: role of NADPH oxidase and mitochondria
Biochim. Biophys. Acta
1783
789-802
2008
Mus musculus
brenda
Miller, R.L.; Sun, G.Y.; Sun, A.Y.
Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase
Brain Res.
1167
129-139
2007
Mus musculus
brenda
Zhao, W.; Zhao, D.; Yan, R.; Sun, Y.
Cardiac oxidative stress and remodeling following infarction: role of NADPH oxidase
Cardiovasc. Pathol.
18
156-166
2008
Mus musculus
brenda
An, S.J.; Boyd, R.; Zhu, M.; Chapman, A.; Pimentel, D.R.; Wang, H.D.
NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts
Cardiovasc. Res.
75
702-709
2007
Mus musculus
brenda
Schlueter, T.; Steinbach, A.C.; Steffen, A.; Rettig, R.; Grisk, O.
Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition
Cardiovasc. Res.
80
271-279
2008
Mus musculus, Rattus norvegicus
brenda
Becker, S.; Reinehr, R.; Graf, D.; vom Dahl, S.; Haeussinger, D.
Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation
Cell. Physiol. Biochem.
19
89-98
2007
Mus musculus
brenda
Doerries, C.; Grote, K.; Hilfiker-Kleiner, D.; Luchtefeld, M.; Schaefer, A.; Holland, S.M.; Sorrentino, S.; Manes, C.; Schieffer, B.; Drexler, H.; Landmesser, U.
Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction
Circ. Res.
100
894-903
2007
Mus musculus
brenda
Mittal, M.; Roth, M.; Koenig, P.; Hofmann, S.; Dony, E.; Goyal, P.; Selbitz, A.C.; Schermuly, R.T.; Ghofrani, H.A.; Kwapiszewska, G.; Kummer, W.; Klepetko, W.; Hoda, M.A.; Fink, L.; Haenze, J.; Seeger, W.; Grimminger, F.; Schmidt, H.H.; Weissmann, N.
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature
Circ. Res.
101
258-267
2007
Homo sapiens, Mus musculus
brenda
Ding, H.; Hashem, M.; Triggle, C.
Increased oxidative stress in the streptozotocin-induced diabetic apoE-deficient mouse: changes in expression of NADPH oxidase subunits and eNOS
Eur. J. Pharmacol.
561
121-128
2007
Mus musculus
brenda
Deng, S.; Kruger, A.; Kleschyov, A.L.; Kalinowski, L.; Daiber, A.; Wojnowski, L.
Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH
Free Radic. Biol. Med.
42
466-473
2007
Mus musculus
brenda
Stokes, K.Y.; Russell, J.M.; Jennings, M.H.; Alexander, J.S.; Granger, D.N.
Platelet-associated NAD(P)H oxidase contributes to the thrombogenic phenotype induced by hypercholesterolemia
Free Radic. Biol. Med.
43
22-30
2007
Mus musculus
brenda
Ribe, D.; Sawbridge, D.; Thakur, S.; Hussey, M.; Ledent, C.; Kitchen, I.; Hourani, S.; Li, J.M.
Adenosine A2A receptor signaling regulation of cardiac NADPH oxidase activity
Free Radic. Biol. Med.
44
1433-1442
2008
Mus musculus
brenda
Datla, S.R.; Dusting, G.J.; Mori, T.A.; Taylor, C.J.; Croft, K.D.; Jiang, F.
Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress
Hypertension
50
636-642
2007
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Babilonia, E.; Lin, D.; Zhang, Y.; Wei, Y.; Yue, P.; Wang, W.H.
Role of gp91phox -containing NADPH oxidase in mediating the effect of K restriction on ROMK channels and renal K excretion
J. Am. Soc. Nephrol.
18
2037-2045
2007
Mus musculus
brenda
Nakashima, T.; Iwashita, T.; Fujita, T.; Sato, E.; Niwano, Y.; Kohno, M.; Kuwahara, S.; Harada, N.; Takeshita, S.; Oda, T.
A prodigiosin analogue inactivates NADPH oxidase in macrophage cells by inhibiting assembly of p47phox and Rac
J. Biochem.
143
107-115
2008
Mus musculus
brenda
Block, K.; Gorin, Y.; Hoover, P.; Williams, P.; Chelmicki, T.; Clark, R.A.; Yoneda, T.; Abboud, H.E.
NAD(P)H oxidases regulate HIF-2alpha protein expression
J. Biol. Chem.
282
8019-8026
2007
Homo sapiens, Mus musculus
brenda
Roepstorff, K.; Rasmussen, I.; Sawada, M.; Cudre-Maroux, C.; Salmon, P.; Bokoch, G.; van Deurs, B.; Vilhardt, F.
Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis
J. Biol. Chem.
283
7983-7993
2008
Mus musculus
brenda
Ding, H.; Aljofan, M.; Triggle, C.R.
Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells
J. Cell. Physiol.
212
682-689
2007
Mus musculus
brenda
Wakisaka, Y.; Miller, J.D.; Chu, Y.; Baumbach, G.L.; Wilson, S.; Faraci, F.M.; Sigmund, C.D.; Heistad, D.D.
Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage
J. Cereb. Blood Flow Metab.
28
1175-1185
2008
Mus musculus
brenda
Fan, J.; Li, Y.; Levy, R.M.; Fan, J.J.; Hackam, D.J.; Vodovotz, Y.; Yang, H.; Tracey, K.J.; Billiar, T.R.; Wilson, M.A.
Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling
J. Immunol.
178
6573-6580
2007
Mus musculus
brenda
Paul, R.; Obermaier, B.; Van Ziffle, J.; Angele, B.; Pfister, H.W.; Lowell, C.A.; Koedel, U.
Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase
J. Leukoc. Biol.
84
1141-1150
2008
Mus musculus
brenda
Zhang, D.; Hu, X.; Wei, S.; Liu, J.; Gao, H.; Qian, L.; Wilson, B.; Liu, G.; Hong, J.
Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
J. Neuroinflammation
5
21
2008
Mus musculus, Rattus norvegicus
brenda
Chiriac, M.T.; Roesler, J.; Sindrilaru, A.; Scharffetter-Kochanek, K.; Zillikens, D.; Sitaru, C.
NADPH oxidase is required for neutrophil-dependent autoantibody-induced tissue damage
J. Pathol.
212
56-65
2007
Homo sapiens, Mus musculus
brenda
Schaeppi, M.; Deffert, C.; Fiette, L.; Gavazzi, G.; Herrmann, F.; Belli, D.; Krause, K.H.
Branched fungal beta-glucan causes hyperinflammation and necrosis in phagocyte NADPH oxidase-deficient mice
J. Pathol.
214
434-444
2008
Mus musculus
brenda
Teixeira, C.E.; Priviero, F.B.; Webb, R.C.
Effects of 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272) on smooth muscle tone, soluble guanylyl cyclase activity, and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal
J. Pharmacol. Exp. Ther.
322
1093-1102
2007
Mus musculus
brenda
Kim, Y.S.; Morgan, M.J.; Choksi, S.; Liu, Z.G.
TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death
Mol. Cell
26
675-687
2007
Mus musculus
brenda
Johnson, K.R.; Marden, C.C.; Ward-Bailey, P.; Gagnon, L.H.; Bronson, R.T.; Donahue, L.R.
Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2
Mol. Endocrinol.
21
1593-1602
2007
Mus musculus
brenda
Jang, H.J.; Hwang, S.; Cho, K.Y.; Kim, d.o..K.; Chay, K.O.; Kim, J.K.
Taxol induces oxidative neuronal cell death by enhancing the activity of NADPH oxidase in mouse cortical cultures
Neurosci. Lett.
443
17-22
2008
Mus musculus
brenda
Kahles, T.; Luedike, P.; Endres, M.; Galla, H.J.; Steinmetz, H.; Busse, R.; Neumann-Haefelin, T.; Brandes, R.P.
NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
Stroke
38
3000-3006
2007
Mus musculus, Sus scrofa
brenda
Riganti, C.; Costamagna, C.; Doublier, S.; Miraglia, E.; Polimeni, M.; Bosia, A.; Ghigo, D.
The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress
Toxicol. Appl. Pharmacol.
228
277-285
2008
Mus musculus
brenda
Shvedova, A.A.; Kisin, E.R.; Murray, A.R.; Kommineni, C.; Castranova, V.; Fadeel, B.; Kagan, V.E.
Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes
Toxicol. Appl. Pharmacol.
231
235-240
2008
Mus musculus
brenda
Hwang, J.; Kleinhenz, D.J.; Rupnow, H.L.; Campbell, A.G.; Thule, P.M.; Sutliff, R.L.; Hart, C.M.
The PPARgamma ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice
Vascul. Pharmacol.
46
456-462
2007
Mus musculus
brenda
Luan, R.; Liu, S.; Yin, T.; Lau, W.B.; Wang, Q.; Guo, W.; Wang, H.; Tao, L.
High glucose sensitizes adult cardiomyocytes to ischaemia/reperfusion injury through nitrative thioredoxin inactivation
Cardiovasc. Res.
83
294-302
2009
Mus musculus
brenda
Yang, X.Q.; Chen, A.F.
High-cholesterol diet augments endothelial dysfunction via elevated oxidative stress and reduced tetrahydrobiopterin in Ins2(Akita) mice, an autosomal dominant mutant type 1 diabetic model
Clin. Exp. Pharmacol. Physiol.
36
764-769
2009
Mus musculus
brenda
Aram, G.; Potter, J.J.; Liu, X.; Wang, L.; Torbenson, M.S.; Mezey, E.
Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration
Hepatology
49
911-919
2009
Mus musculus
brenda
Haruta, M.; Bush, R.A.; Kjellstrom, S.; Vijayasarathy, C.; Zeng, Y.; Le, Y.Z.; Sieving, P.A.
Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function
Proc. Natl. Acad. Sci. USA
106
9397-9402
2009
Mus musculus
brenda
Arora, S.; Vaishya, R.; Dabla, P.K.; Singh, B.
NAD(P)H oxidases in coronary artery disease
Adv. Clin. Chem.
50
65-86
2010
Oryctolagus cuniculus, Homo sapiens, Mus musculus
brenda
Matsushima, S.; Kinugawa, S.; Yokota, T.; Inoue, N.; Ohta, Y.; Hamaguchi, S.; Tsutsui, H.
Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes
Am. J. Physiol. Heart Circ. Physiol.
297
H409-H416
2009
Mus musculus
brenda
Piwkowska, A.; Rogacka, D.; Jankowski, M.; Dominiczak, M.H.; Stepi?ski, J.K.; Angielski, S.
Metformin induces suppression of NAD(P)H oxidase activity in podocytes
Biochem. Biophys. Res. Commun.
393
268-273
2010
Mus musculus
brenda
Gao, L.; Mann, G.E.
Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling
Cardiovasc. Res.
82
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2009
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Ben Mkaddem, S.; Pedruzzi, E.; Werts, C.; Coant, N.; Bens, M.; Cluzeaud, F.; Goujon, J.; Ogier-Denis, E.; Vandewalle, A.
Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury
Cell Death Differ.
17
1474-1485
2010
Mus musculus
brenda
Wang, S.; Zhang, M.; Liang, B.; Xu, J.; Xie, Z.; Liu, C.; Viollet, B.; Yan, D.; Zou, M.H.
AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes
Circ. Res.
106
1117-1128
2010
Homo sapiens, Mus musculus
brenda
Saitoh, Y.; Hongwei, W.; Ueno, H.; Mizuta, M.; Nakazato, M.
Telmisartan attenuates fatty-acid-induced oxidative stress and NAD(P)H oxidase activity in pancreatic beta-cells
Diabetes Metab.
35
392-397
2009
Mus musculus
brenda
Bhandarkar, S.S.; Jaconi, M.; Fried, L.E.; Bonner, M.Y.; Lefkove, B.; Govindarajan, B.; Perry, B.N.; Parhar, R.; Mackelfresh, J.; Sohn, A.; Stouffs, M.; Knaus, U.; Yancopoulos, G.; Reiss, Y.; Benest, A.V.; Augustin, H.G.; Arbiser, J.L.
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice
J. Clin. Invest.
119
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2009
Mus musculus
brenda
Kleinschnitz, C.; Grund, H.; Wingler, K.; Armitage, M.E.; Jones, E.; Mittal, M.; Barit, D.; Schwarz, T.; Geis, C.; Kraft, P.; et al
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration
PLoS Biol.
8
e1000479
2010
Homo sapiens, Mus musculus
brenda
Zhao, R.; Le, K.; Moghadasian, M.H.; Shen, G.X.
Regulatory role of NADPH oxidase in glycated LDL-induced upregulation of plasminogen activator inhibitor-1 and heat shock factor-1 in mouse embryo fibroblasts and diabetic mice
Free Radic. Biol. Med.
61C
18-25
2013
Mus musculus, Mus musculus C57BL/6
brenda
Matsumoto, M.; Katsuyama, M.; Iwata, K.; Ibi, M.; Zhang, J.; Zhu, K.; Nauseef, W.M.; Yabe-Nishimura, C.
Characterization of N-glycosylation sites on the extracellular domain of NOX1/NADPH oxidase
Free Radic. Biol. Med.
68
196-204
2014
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Donko, A.; Morand, S.; Korzeniowska, A.; Boudreau, H.E.; Zana, M.; Hunyady, L.; Geiszt, M.; Leto, T.L.
Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2
Free Radic. Biol. Med.
73
190-200
2014
Mus musculus
brenda
Bermudez, S.; Khayrullina, G.; Zhao, Y.; Byrnes, K.R.
NADPH oxidase isoform expression is temporally regulated and may contribute to microglial/macrophage polarization after spinal cord injury
Mol. Cell. Neurosci.
77
53-64
2016
Mus musculus
brenda
Al-Harbi, N.O.; Nadeem, A.; Ansari, M.A.; Al-Harbi, M.M.; Alotaibi, M.R.; AlSaad, A.M.; Ahmad, S.F.
Psoriasis-like inflammation leads to renal dysfunction via upregulation of NADPH oxidases and inducible nitric oxide synthase
Int. Immunopharmacol.
46
1-8
2017
Mus musculus (Q9JHI8)
brenda
Quesada, I.; de Paola, M.; Alvarez, M.S.; Hapon, M.B.; Gamarra-Luques, C.; Castro, C.
Antioxidant and anti-atherogenic properties of Prosopis strombulifera and Tessaria absinthioides aqueous extracts modulation of NADPH oxidase-derived reactive oxygen species
Front. Physiol.
12
662833
2021
Mus musculus, Rattus norvegicus
brenda