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Information on EC 1.5.98.3 - coenzyme F420:methanophenazine dehydrogenase

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IUBMB Comments
The enzyme, found in some methanogenic archaea, is responsible for the reoxidation of coenzyme F420, which is reduced during methanogenesis, and for the reduction of methanophenazine to dihydromethanophenazine, which is required by EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase. The enzyme is membrane-bound, and is coupled to proton translocation across the cytoplasmic membrane, generating a proton motive force that is used for ATP generation.
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The expected taxonomic range for this enzyme is: Methanosarcinales
Synonyms
F420-phenazine oxidoreductase, F420H2 dehydrogenase, F420H2-dehydrogenase, ffd, Fpo, FpoAHJKLMN, fpoBCDIF, FPOF, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
reduced coenzyme F420 + methanophenazine = oxidized coenzyme F420 + dihydromethanophenazine
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