Information on EC 1.5.98.3 - coenzyme F420:methanophenazine dehydrogenase

The enzyme, found in some methanogenic archaea, is responsible for the reoxidation of coenzyme F₄₂₀, which is reduced during methanogenesis, and for the reduction of methanophenazine to dihydromethanophenazine, which is required by EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase. The enzyme is membrane-bound, and is coupled to proton translocation across the cytoplasmic membrane, generating a proton motive force that is used for ATP generation.