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Information on EC 1.5.98.2 - 5,10-methylenetetrahydromethanopterin reductase and Organism(s) Methanothermobacter marburgensis and UniProt Accession Q50744

for references in articles please use BRENDA:EC1.5.98.2
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IUBMB Comments
Catalyses an intermediate step in methanogenesis from CO2 and H2 in methanogenic archaea.
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This record set is specific for:
Methanothermobacter marburgensis
UNIPROT: Q50744
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Word Map
The taxonomic range for the selected organisms is: Methanothermobacter marburgensis
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
n5,n10-methylenetetrahydromethanopterin reductase, mk0524, 5,10-methylenetetrahydromethanopterin reductase, h2-dependent methylenetetrahydromethanopterin dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
N5,N10-methylenetetrahydromethanopterin reductase
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N5,N10-methylenetetrahydromethanopterin reductase (coenzyme F420-dependent)
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5,10-methylene-H4MPT reductase
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coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase
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H(2)-dependent methylene-H(4)MPT dehydrogenase
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H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase
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N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase
Catalyses an intermediate step in methanogenesis from CO2 and H2 in methanogenic archaea.
CAS REGISTRY NUMBER
COMMENTARY hide
100357-01-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
N5,N10-methylenetetrahydromethanopterin + reduced coenzyme F420
5-methyl-5,6,7,8-tetrahydromethanopterin + oxidized coenzyme F420
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N5,N10-methylenetetrahydromethanopterin + reduced coenzyme F420
5-methyl-5,6,7,8-tetrahydromethanopterin + oxidized coenzyme F420
show the reaction diagram
the enzyme is involved in methanogenesis from CO2
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
phosphate
maximal stimulation (5-6fold) at 1 M. Sodium-, potassium-, and ammonium salts of phosphate are equally effective
sulfate
maximal stimulation (5-6fold) at 1 M. Sodium-, potassium-, and ammonium salts of sulfate are equally effective
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is involved in methanogenesis from CO2
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ma, K.; Linder, D.; Stetter, K.O.; Thauer, R.K.
Purification and properties of N5,N10-methylenetetrahydromethanopterin reductase (coenzyme F420-dependent) from the extreme thermophile Methanopyrus kandleri
Arch. Microbiol.
155
593-600
1991
Methanopyrus kandleri (Q8TXY4), Methanopyrus kandleri, Methanopyrus kandleri DSM 6324 (Q8TXY4), Methanosarcina barkeri, Methanothermobacter marburgensis (Q50744), Methanothermobacter marburgensis DSM 2133 (Q50744)
Manually annotated by BRENDA team