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Information on EC 1.5.8.3 - sarcosine dehydrogenase

for references in articles please use BRENDA:EC1.5.8.3

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IUBMB Comments

A flavoprotein (FMN) found in eukaryotes. In the absence of tetrahydrofolate the enzyme produces formaldehyde. cf. EC 1.5.3.1, sarcosine oxidase (formaldehyde-forming), and EC 1.5.3.24, sarcosine oxidase (5,10-methylenetetrahydrofolate-forming).

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
sarcosine dehydrogenase, sardh, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
sarcosine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = glycine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
creatinine degradation I, creatinine degradation II, glycine betaine degradation II (mammalian)
Highest Expressing Human Cell Lines
Cell Line Links Gene Links