Disease on EC 1.5.5.2 - proline dehydrogenase

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DISEASE
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22q11 Deletion Syndrome
Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function.
PRODH rs450046 and proline x COMT Val¹?? Met interaction effects on intelligence and startle in adults with 22q11 deletion syndrome.
Breast Neoplasms
Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX-Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model.
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells.
Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells.
Sources of superoxide/H2O2 during mitochondrial proline oxidation.
Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition.
Carcinogenesis
Proline dehydrogenase (oxidase) in cancer.
Carcinoma
Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death.
Catatonia
Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study.
Coma
Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study.
Dehydration
A nuclear gene encoding mitochondrial proline dehydrogenase, an enzyme involved in proline metabolism, is upregulated by proline but downregulated by dehydration in Arabidopsis.
ACTCAT, a novel cis-acting element for proline- and hypoosmolarity-responsive expression of the ProDH gene encoding proline dehydrogenase in Arabidopsis.
Effect of Exogenous Abscisic Acid on Proline Dehydrogenase Activity in Maize (Zea mays L.).
Effect of water stress on growth and proline metabolism of Phaseolus vulgaris L.
Expression analysis of proline metabolism-related genes from halophyte Arabis stelleri under osmotic stress conditions.
Regulation of levels of proline as an osmolyte in plants under water stress.
DiGeorge Syndrome
Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects.
Early neurological phenotype in 4 children with biallelic PRODH mutations.
Hyperprolinemia is a risk factor for schizoaffective disorder.
Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes.
The 22q11 PRODH/DGCR6 deletion is frequent in hyperprolinemic subjects but is not a strong risk factor for ASD.
Encephalitis
Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study.
Epilepsy
Type I hyperprolinemia and proline dehydrogenase (PRODH) mutations in four Italian children with epilepsy and mental retardation.
Heart Failure
Exercise Reveals Proline Dehydrogenase as a Potential Target in Heart Failure.
Hypersensitivity
Altered levels of proline dehydrogenase cause hypersensitivity to proline and its analogs in Arabidopsis.
Infections
Differential control and function of Arabidopsis ProDH1 and ProDH2 genes upon infection with biotrophic and necrotrophic pathogens.
P5CDH affects the pathways contributing to Pro synthesis after ProDH activation by biotic and abiotic stress conditions.
Insomnia, Fatal Familial
Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study.
Intellectual Disability
Type I hyperprolinemia and proline dehydrogenase (PRODH) mutations in four Italian children with epilepsy and mental retardation.
Neoplasm Metastasis
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells.
Neoplasms
1-Pyrroline-5-carboxylate released by prostate Cancer cell inhibit T cell proliferation and function by targeting SHP1/cytochrome c oxidoreductase/ROS Axis.
Expression signatures in lung cancer reveal a profile for EGFR-mutant tumours and identify selective PIK3CA overexpression by gene amplification.
In search of druggable targets for GBM amino acid metabolism.
P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements.
Prolidase-proline dehydrogenase/proline oxidase-collagen biosynthesis axis as a potential interface of apoptosis/autophagy.
Proline dehydrogenase (oxidase) in cancer.
Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment.
Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death.
Proline metabolism and cancer.
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells.
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.
Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress.
Sources of superoxide/H2O2 during mitochondrial proline oxidation.
Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition.
The Proline Cycle As a Potential Cancer Therapy Target.
Nervous System Diseases
Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH.
Neurologic Manifestations
PRODH mutations and hyperprolinemia in a subset of schizophrenic patients.
proline dehydrogenase deficiency
Mitochondrial proline dehydrogenase deficiency in hyperprolinemic PRO/Re mice: genetic and enzymatic analyses.
Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice.
pyrroline-5-carboxylate reductase deficiency
Identification of PRODH Mutations in Korean Neonates with Type I Hyperprolinemia.
Seizures
Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study.
Sleep Initiation and Maintenance Disorders
Medical and developmental risk factors of catatonia in children and adolescents: A prospective case-control study.
Starvation
Heterodimers of the Arabidopsis Transcription Factors bZIP1 and bZIP53 Reprogram Amino Acid Metabolism during Low Energy Stress.
Tuberculosis
Kinetic and Isotopic Characterization of l-Proline Dehydrogenase from Mycobacterium tuberculosis.